Supplemental material 2. Sensitivity, specificity, PPV, NPV, diagnostic accuracy of cut-off values of conventional indicators in IVIG resistance prediction.
Sensitivity Specificity PPV NPV Diagnostic accuracy
OR
(95% CI) P value
CRP ≥55.5 0.78 0.40 0.23 0.89 0.47 2.37
(1.43-3.95) 0.001
ESR ≥61.5 0.67 0.49 0.24 0.86 0.44 1.91
(1.17-3.12) 0.012
AST ≥46.5 0.42 0.75 0.28 0.85 0.69 2.16
(1.38-3.39) 0.001
TB ≥9.55 0.35 0.80 0.28 0.84 0.71 2.14
(1.33-3.43) 0.002
BUN ≥3.20 0.38 0.75 0.26 0.84 0.68 1.84
(1.16-2.90) 0.013
ALT ≥46.5 0.57 0.67 0.29 0.87 0.65 2.74
(1.76-4.27) ＜0.001
ALB ≤35.8 0.51 0.66 0.25 0.85 0.63 1.9
(1.26-3.02) 0.003
Na+ ≤136.0 0.63 0.60 0.26 0.88 0.58 2.47
(1.57-3.90) ＜0.001
NLR ≥3.37 0.59 0.61 0.25 0.87 0.61 2.31
(1.49-3.60) ＜0.001
PLR ≥124 0.56 0.65 0.27 0.87 0.63 2.41
(1.57-3.86) ＜0.001 NLR ≥3.37
PLR ≥124 0.48 0.73 0.29 0.86 0.68 2.45
(1.56-3.87) ＜0.001 ALT ≥46.5
NLR ≥3.37 0.34 0.83 0.31 0.84 0.74 2.47
(1.53-4.00) ＜0.001 ALT ≥46.5
PLR ≥124 0.30 0.85 0.31 0.84 0.74 2.35
(1.43-3.88) 0.001 ALT ≥46.5
NLR ≥3.37 PLR ≥124
0.28 0.87 0.33 0.84 0.76 2.63
(1.57-4.42) ＜0.001 ALB ≤35.8
NLR ≥3.37 0.28 0.83 0.27 0.83 0.72 1.84
(1.11-3.03) 0.024 ALB ≤35.8
PLR ≥124 0.28 0.88 0.35 0.84 0.77 2.93
(1.73-4.94) ＜0.001 ALB ≤35.8
NLR ≥3.37 PLR ≥124
0.28 0.88 0.35 0.84 0.77 2.52
(1.45-4.41) 0.002 Na+ ≤136.0
NLR ≥3.37 0.48 0.71 0.27 0.85 0.66 3.04
(1.91-4.83) ＜0.001
Na+≤136.0
PLR ≥124 0.40 0.83 0.35 0.86 0.72 3.24
(2.00-5.25) ＜0.001 Na+ ≤136.0
NLR ≥3.37 PLR ≥124
0.34 0.85 0.34 0.85 0.72 2.93
(1.78-4.82) ＜0.001 Abbreviations: ALB, albumin; ALT,alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IVIG, intravenous immunoglobulin; NLR, neutrophil-to-lymphocyte ratio; NPV, negative predictive value; Platelet-to- lymphocyte ratio=PLR; PPV, positive predictive value; Na+, sodium; TB, total bilirubin.
