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Supplementary Table. Clinical Characteristics, treatment, and outcomes of patients with adenoid cystic carcinoma in orbit.

Case

no Age, y

Follow-up time after surgery, mo

Last follow- up status

8

^th

AJCC stage grouping

Histologic

subtype Treatment

Secondary treatment for recurrence

Tertiary treatment for

recurrence Remarks

1 55 217 ANED T2cN0M0 Crib Resect + Bone + RT

2 40 217 ANED T2aN0M0 Crib/Soli Resect + RT

3 43 144 ANED T2aN0M0 Crib Resect + RT Exent

4 64 145 ANED T2aN0M0 Crib/Tubu Resect + RT

5 24 111 ANED T3aN0M0 Crib Resect + RT

6 43 77 ANED T2aN0M0 Crib/Soli Resect + RT

8 67 58 Dead§ T3aN0M0 Crib Resect + RT Died due to esophageal squamous cell carcinoma

9 26 41 ANED T2aN0M0 Tubu Resect + RT

11 40 191 Local recurrence T2cN0M0 Tubu Resect + RT Follow-up loss after recurrence

12 44 39 DOD T4bNxM1 Crib/Tubu RT

13 39 188 ANED T4bN0M0 N/A Exent + RT

14 31 99 ANED T4bN0M0 Crib/Soli GK, Exent + Bone

15 40 25 DOD T4bN0M1 N/A RT

16 51 32 DOD T4bN0M0 Tubu Exent

17 28 25 DOD T4bN0M0 Crib/Soli CT

18 26 61 DOD T2aN0M0 N/A Resect Refuse Patient refused treatment for recurrence

19 72 78 Local recurrence T4bN0M0 Soli/Tube IACC + Resect + RT Follow-up loss after recurrence

20 43 33 DOD T4bN0M0 Soli RT, CT Primary tumor arose from nasopharynx

21 13 85 ANED T2cN0M0 N/A Resect + CT Resect Resect + RT

22 61 23 AWD T4bN0M0 Tubu Exent + RT

23 28 2 AWD T3cN0M0 N/A CT

24 64 67 ANED T2aN0M0 Crib/Tubu Resect Exent + RT

25 43 40 ANED T4bN0M0 Crib/Tubu Exent + Bone + RT

26 67 4 ANED T4bN0M0 Crib/Soli Exent

27 32 42 AWD T4aN0M0 Tubu Resect + RT Invasions to intracranial areas

ANED = alive with no evidence of disease; DOD = died of disease; AWD = alive with disease; Crib = cribriform subtype; Soli = solid subtype; Tubu = tubular subtype; N/A =

not applicable; Resect + Bone + RT = resection of mass with removal of adjacent bone plus postoperative radiation therapy; Resect + RT = resection of mass plus postoperative

radiation therapy; Resect = resection of mass; IACC = intraarterial cytoreductive chemotherapy; Resect + CT = resection of mass plus postoperative chemotherapy; GK =

gamma knife therapy; Exent + bone + RT = exenteration with removal of orbital wall fragment plus postoperative radiation therapy; Exent + RT = exenteration plus

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postoperative radiation therapy; RT = radiotherapy; CT = chemotherapy; Date of incisional biopsy substituted for the date of tumor excision as for the patients who didn’t