Supplemental table 1. Main baseline data of Randomized Controlled Trials Included in the Meta-analysis.
study Country Difficult
cannulation
Mean age(y) % female technical details Total patients adverse events OR RR
Precut standard precut standard precut standard precut standard precut standard Cennomo, 2009[23] Italy > 5 min or >2
attempts
68 71 56 54 Fistulotomy wire guided 36 110 3 7 1.34 1,31
Manes, 2009[9] Italy > 10 min or >4 attempts
66 65 34 33 Fistulotomy wire and non –
wire guided
77 74 7 14 0.43 0.50
Mariani, 2016[13] Italy > 5 min or >3 attempts
70.4 68.2 52.4 59.5 Fistulotomy wire guided 185 190 18 31 0.55 0.60
Swan, 2013[21] Australia > 10 min or >3 attempts
57 59 72 66 Papillotomy wire guided 39 34 9 8 0.98 0.98
Tang, 2005[22] Canada > 12 min 64 67 53 53 Fistulotomy non –wire guided 32 2 4 30 2.0 1.88
Zhou, 2006[20] China > 10 min or >2 attempts
63 64 40 40 Papillotomy or
Fistulotomy
wire and non – wire guided
43 48 2 2 1.12 1.12
Supplemental table 2．Data Collection From Included studies in the Meta-analysis.
Primary cannulation rate Pancreatitis rate Overall cannulation rate Overall complication rate
study precut standard precut standard precut standard precut Standard Non-salvage precut Salvage precut total
Cennomo, 2009[23] 33/36 78/110 1/36 6/78 0/32 6/110 33/36 104/110 3/36 7/110
Manes, 2009[9] 63/77 16/74 2/77 4/24 7/50 11/74 71/77 71/74 7/77 14/74
Mariani, 2016[13] 168/185 55/190 10/185 4/55 19/135 23/19
0
179/182 183/190 18/185 31/190
Swan, 2013[21] 34/39 12/34 8/39 3/12 3/22 6/34 34/39 29/34 9/39 8/34
Tang, 2005[22] 24/32 22/30 2/32 1/27 1/3 2/30 31/32 28/30 4/32 2/30
Zhou, 2006[20] 39/43 36/48 1/43 2/48 0 2/48 39/43 36/48 2/43 2/48
Supplemental table 3. Revised Jadad`s scoring system of Randomized Controlled Trials Included in the Meta-analysis.
Studies Generation of allocation sequences Allocation concealment Blinding Intent to treat Jadad score
Cennomo, 2009[23] 2 0 1 0 3
Manes, 2009[9] 1 1 1 1 4
Mariani, 2016[13] 2 1 1 2 6
Swan, 2013[21] 2 0 0 1 3
Tang, 2005[22] 2 0 2 2 6
Zhou, 2006[20] 2 0 1 0 3
Low risk of bias receives 2scores; unclear risk of bias receives 1 scores; high risk of bias receives 0 score.
