Supplementary TABLE 1.Overall and sex-age-specific incidence rate and hazard ratio ofcarpal tunnel syndrome associated with diabetes.
Sex / Age (years)
Diabetic cohort Control cohort
Crude HR (95% CI)
Adjusted HR (95%
Person- CI) years
No. of event
Incidence rate (95% CI)*
Person- years
No. of event
Incidence rate (95% CI)* Males
<
35
73519 197 26.8 (23.1-30.5) 75298 101 13.4 (10.8-16.0) 2.00 (1.57-2.54) 2.05 (1.60-2.63)
35-64 1336282 6532 48.9 (47.7-50.1) 1457583 5085 34.9 (33.9-35.9) 1.40 (1.35-1.46) 1.41 (1.35-1.48)
>
65
720802 2732 37.9 (36.5-39.3) 813666 2438 30.0 (28.8-31.2) 1.26 (1.19-1.33) 1.27 (1.19-1.35)
Total 2130603 9461 44.4 (43.5-45.3) 2346548 7624 32.5 (31.8-33.2) 1.37 (1.33-1.41) 1.38 (1.33-1.43)
Females
<
35
63245 430 68.0 (61.6-74.4) 65822 197 29.9 (25.8-34.1) 2.27 (0.73-1.02) 2.31 (1.91-2.78)
35-64 1356389 14302 105.4 (103.7-
107.2)
1470563 12726 86.5 (85.0-88.0) 1.22 (1.19-1.25) 1.26 (1.22-1.30)
>
65
897726 4071 45.4 (44.0-46.7) 1030141 3948 38.3 (37.1-39.5) 1.17 (1.12-1.23) 1.19 (1.12-1.26)
Total 2317360 18803 81.1 (80.0-82.3) 2566526 16871 65.7 (64.7-66.7) 1.23 (1.21-1.26) 1.27 (1.24-1.31)
Overall 4447963 28264 63.5 (62.8-64.3) 4913074 24495 49.9 (49.2-50.5) 1.27 (1.25-1.30) 1.31 (1.28-1.34)
* Per 10,000 person-years
p-value for the interaction of diabetes with sex = 0.0006; p-value for the interaction of diabetes with age in males and females = 0.0044 and 0.0273, respectively Abbreviations: CI = confidence interval; HR= hazard ratio
Supplementary TABLE 2.Overall and sex-age-specific incidence rate and hazard ratio of stenosingflexortenosynovitis associated with diabetes.
Sex / Age (years)
Diabetic cohort Control cohort
Crude HR(95% CI)
Adjusted HR (95% CI) Person-
years
No. of event
Incidence rate (95% CI)*
Person- years
No.
of even
t
Incidence rate (95% CI)*
Males
<
35
73781 147 19.9 (16.7-23.1) 75577 36 4.8 (3.2-6.3) 4.27 (2.96-6.16) 4.87 (3.27-7.24)
35-64 134283
4
5442 40.5 (39.5-41.6) 1466742 3188 21.7 (21.0-22.5) 1.90 (1.82-1.98) 1.97 (1.87-2.07)
>
65
721089 2589 35.9 (34.5-37.3) 816692 1715 21.0 (20.0-21.9) 1.72 (1.62-1.83) 1.70 (1.58-1.82)
Total 213770
4
8178 38.3 (37.4-39.1) 2359011 4939 20.9 (20.4-21.5) 1.85 (1.79-1.92) 1.89 (1.82-1.97)
Females
<
35
63832 319 50.0 (44.5-55.5) 66337 68 10.3 (7.8-12.7) 4.98 (3.83-6.47) 5.45 (4.08-7.29)
35-64 136483
6
13858 101.5 (99.9- 103.2)
1495429 8249 55.2 (53.9-56.4) 1.86 (1.81-1.92) 1.94 (1.87-2.01)
>
65
901274 3343 37.1 (35.8-38.4) 1037259 2553 24.6 (23.7-25.6) 1.52 (1.44-1.60) 1.61 (1.49-1.73)
Total 232994
2
17520 75.2 (74.1-76.3) 2599025 1087
0
41.8 (41.0-42.6) 1.83 (1.78-1.87) 1.91 (1.85-1.97)
Overall 446764 6
25698 57.5(56.8-58.2) 4958036 1580
9
31.9(31.4-32.4) 1.83(1.79-1.87) 1.90 (1.86-1.95)
* Per 10,000 person-years
p-value for the interaction of diabetes with sex = 0.7764 p-value for the interaction of diabetes with age in males and females = 0.0004 and <0.0001, respectively Abbreviations: CI = confidence interval; HR= hazard ratio
Supplementary TABLE 3.Overall and sex-age-specific incidence rate and hazard ratio of limited joint mobility associated with diabetes.
Sex / Age (years)
Diabetic cohort Control cohort
Crude HR(95%
CI)
Adjusted HR (95% CI) Person-
years
No. of event
Incidence rate (95% CI)*
Person- years
No. of event
Incidence rate (95% CI)* Males
<
35
74234 11 1.5 (0.7-2.7) 75646 9 1.2 (0.5-2.3) 1.21 (0.50-2.92) 1.34 (0.54-3.35)
35-64 1362639 325 2.4 (2.1-2.6) 147819
0
242 1.6 (1.4-1.8) 1.44 (1.22-1.70) 1.49 (1.22-1.82)
>
65
730807 368 5.0 (4.5-5.6) 822625 333 4.0 (3.6-4.5) 1.19 (1.03-1.38) 1.22 (1.02-1.45)
Total 2167680 704 3.3 (3.0-3.5) 237646
1
584 2.5 (2.3-2.7) 1.29 (1.15-1.44) 1.34 (1.46-2.89)
Females
<
35
64967 4 0.6 (0.2-1.6) 66550 2 0.3 (0.04-1.1) 1.99 (0.37-
10.87)
2.01 (0.36-11.20)
5
>
65
914010 462 5.1 (4.6-5.5) 104592
1
483 4.6 (4.2-5.0) 1.05 (0.92-1.19) 1.01 (0.85-1.21)
Total 2396704 992 4.1 (3.9-4.4) 263908
6
939 3.6 (3.3-3.8) 1.14 (1.04-1.24) 1.16 (1.03-1.31)
Overall 4564384 1696 3.7 (3.5-3.9) 501554
7
1523 3.0 (2.9-3.2) 1.19 (1.11-1.28) 1.24 (1.13-1.35)
* Per 10,000 person-years, CI = confidence interval
p-value for the interaction of diabetes with sex = 0.1248 p-value for the interaction of diabetes with age in males and females = 0.2366 and 0.0696, respectively Abbreviations: CI = confidence interval; HR= hazard ratio
Supplementary TABLE 4.Overall and sex-age-specific incidence rate and hazard ratio of Dupuytren’s Disease associated with diabetes.
Sex / Age (years)
Diabetic cohort Control cohort
Crude HR(95% CI)
Adjusted HR (95%
Person- CI) years
No. of event
Incidence rate (95% CI)*
Person -years
No. of event
Incidence rate (95% CI)* Males
<
35
74287 1 0.13 (0.003-0.75) 75687 0 0 NA NA
35-64 136399
2
41 0.30 (0.21-0.39) 147931 0
20 0.14 (0.08-0.20) 2.28 (1.33- 3.89)
1.90 (1.07-3.37)
>
65
732217 69 0.94 (0.72-1.17) 824125 35 0.42 (0.28-0.57) 2.21 (1.47-
3.32)
2.05 (1.34-3.14)
Total 217049
6
111 0.51 (0.42-0.61) 237912 2
55 0.23 (0.17-0.29) 2.22 (1.61- 3.07)
2.05 (1.46-2.89)
Females
<
35
64987 1 0.15 (0.004-0.86) 66563 0 0 NA NA
35-64 142016
2
47 0.33 (0.24-0.43) 152878 7
34 0.22 (0.15-0.30) 1.50 (0.97- 2.34)
1.28 (0.72-2.28)
>
65
916113 25 0.27 (0.17-0.38) 104828
3
20 0.19 (0.11-0.27) 1.40 (0.78- 2.53)
1.54 (0.72-3.30)
Total 240126
2
73 0.30 (0.23-0.37) 264363 3
54 0.20 (0.15-0.26) 1.50 (1.05- 2.13)
1.40 (0.89-2.21)
Overall 457175
8
184 0.40 (0.34-0.46) 502275 5
109 0.22 (0.18-0.26) 1.86 (1.47- 2.36)
1.83 (1.39-2.39)
* Per 10,000 person-years
p-value for the interaction of diabetes with sex = 0.1598; p-value for the interaction of diabetes with age in males and females = 0.8535 and 0.8399, respectively CI = confidence interval; HR= hazard ratio; NA=not applicable