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Table S1 The prevalence of chronic urticaria and pollen counts in adults

January February March April May June July August Septembe

r October Novembe

r

Decembe r Chronic urticaria,

n(%) 10(5.2) 10(5.2) 23(12) 39(20.4) 40(20.9) 37(19.4) 53(27.8) 44(23) 30(15.7) 17(8.9) 20(10.5) 18(9.4)

Pollen counts 190.7 227.7 795.8 7657.7 4113.0 474.7 2997.7 13697.5 4185.0 1100.2 217.0 310.3

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Table S2 Factors that had no significant correlation with chronic urticaria

Project CU, n(%) Without CU,

n(%) X² value P value

Age group (y) 4.149 .13

18-39 85(5.99) 1333(94.01)

40-59 87(5.90) 1388(94.10)

≥60 19(3.70) 494(96.30)

Race 0.080 .95

Han 109(5.54) 1860(94.46)

Mongolian 74(5.67) 1231(94.33)

Others 8(6.06) 124(93.94)

Heating ways 3.399 .33

Central heating 141(6.04) 2195(93.96)

Coal heating 20(4.71) 405(95.29)

Wood heating 19(4.13) 441(95.87)

Others 11(5.95) 174(94.05)

Pet keeping 1.987 .16

Yes 35(4.58) 730(95.42)

No 156(6.21) 2485(93.79)

History of previous surgery 0.598 .44

Yes 71(6.03) 1107(93.97)

No 120(5.39) 2108(94.61)

Vaccination allergy history 1.624 .40

Yes 2(11.11) 16(88.89)

No 182(5.57) 3088(94.43)

Unknown 7(5.93) 111(94.07)

Multiple use of antibiotics 3.175 .08

Yes 44(7.10) 576(92.90)

No 147(5.28) 2639(94.72)

Hypertension 1.335 .25

Yes 36(4.76) 721(95.24)

No 155(5.85) 2494(94.15)

Heart disease 0.007 .93

Yes 36(5.54) 614(94.46)

No 155(5.62) 2601(94.38)

Diabetes 1.537 .22

Yes 6(3.49) 166(96.51)

No 185(5.72) 3049(94.28)

Apoplexy 0.000 .99

Yes 2(5.56) 34(94.44)

No 189(5.61) 3181(94.39)

Asthma 1.606 .21

Yes 16(7.55) 196(92.45)

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No 175(5.48) 3019(94.52)

Chi-square test and Fisher exact test were performed in this table Abbreviations: CU---chronic urticaria

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Table S3 Chronic urticaria related risk factors.

project CU, n(%) without CU, n(%) X²

value

P value

Gender 12.785 <.001

Male 64(4.08) 1504(95.92)

Female 127(6.91) 1711(93.09)

Level of education 12.308 <.01

Below primary school 5(2.51) 194(97.49)

Primary school 25(4.80) 496(95.20)

Middle school 70(4.87) 1366(95.13)

University degree or above 91(7.28) 1159(92.72)

Residence 8.716 <.01

Urban 112(6.81) 1532(93.19)

Rural 79(4.48) 1683(95.52)

Outdoor activity time 13.612 <.01

<1 hour 41(7.78) 486(92.22)

1 to 2 hours 64(6.95) 857(93.05)

2 to 3 hours 30(4.46) 642(95.54)

3 to 4 hours 15(29.26) 378(70.74)

>4 hours 41(4.59) 852(95.41)

Smoking habit 10.075 <.01

Never smoking 156(6.26) 2336(93.74)

Now Smoking 22(3.15) 677(96.85)

Ever smoking 13(6.05) 202(93.95)

Family allergy history 38.235 <.001

Yes 98(9.22) 965(90.78)

No 88(3.93) 2152(96.07)

Unknown 5(4.85) 98(95.15)

Eczema 59.190 <.001

Yes 46(15.38) 253(84.62)

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No 145(4.67) 2962(95.33)

History of food allergy 40.269 <.001

Yes 47(12.81) 320(87.19)

No 144(4.80) 2859(95.20)

History of drug allergy 17.574 <.001

Yes 56(9.14) 557(90.86)

No 135(4.83) 2658(95.17)

Allergic rhinitis 18.852 <.001

Yes 96(7.91) 1118(92.09)

No 95(4.33) 2097(95.67)

Conjunctivitis 40.056 <.001

Yes 105(9.09) 1050(90.91)

No 86(3.82) 2165(96.18)

Sleepiness 18.327 <.001

No 122(4.98) 2330(95.02)

Occasional 41(5.75) 672(94.25)

Long-term 28(11.62) 213(88.38)

Oral ulcer 7.028 .03

No 146(5.15) 2689(94.85)

Occasional 35(7.61) 425(92.39)

Long-term 10(9.01) 101(90.99)

Fatigue 27.487 <.001

No 109(4.57) 2274(95.43)

Occasional 49(6.54) 700(93.46)

Long-term 33(12.04) 241(87.96)

Diarrhea 26.215 <.001

No 150(4.98) 2861(95.02)

Occasional 25(8.56) 267(91.44)

Chronic 16(15.53) 87(84.47)

Constipation 10.092 <.01

No 154(5.41) 2695(94.59)

Occasional 18(4.70) 365(95.30)

Long-term 19(10.92) 155(89.08)

Abdominal pain 17.194 <.001

No 155(5.07) 2900(94.93)

Occasional 25(8.90) 256(91.10)

Long-term 11(15.71) 59(84.29)

Chi-square test and Fisher exact test were performed in this table.

Abbreviations: CU---chronic urticaria

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Questionnaire

Demographic information Study ID: ________

Name: ________ Sex: 1 Male  2 Female  ID card number: ________ Telephone number: ________

Actual date of birth: _____Year _____Month _____Day Nation: 1 Han  2 Mongolian  3 Other 

Level of education: 1 Elementary school or below  2 Middle School  3 University or above 

Height: ______cm Weight: _____kg

Current residence: 1 Urban areas  2 Rural areas  Urticaria

1 Have you ever had the symptoms of wheal in the past 12 months?

I Yes  II No （If no, go to next section）

2 Did the wheal regress spontaneous within 24 hours? I Yes  II No  3 Did the wheal regress without traces? I Yes  II No 

4 Did the wheal occur at least twice a week? I Yes  II No  5 How long did the symptoms last? I ≥6 weeks  II <6 weeks  6 In what occasion did the symptoms occur?

I Perennial without seasonal change (If so, go to next section) II Seasonal (spring, summer or autumn)  III Perennial with seasonal  IV Perennial with in winter  V Others 

7 If the symptoms were seasonal or seasonal exacerbation, in which months did they occur in the past 12 months? (Multiple choices)

Janu ary

Febru ary

Mar ch

Ap ril

M ay

Ju ne

Ju ly

Aug ust

Septe mber

Octo ber

Nove mber

Dece mber Rhinitis

1 Do you have the following symptoms repeatedly in the past 12 months？ I Yes  II No （If no, go to next section）

I Yes 2 No

Itchy nose  

Sneeze  

Nasal discharge  

Nasal congestion  

2 In what occasion did the symptoms occur?

Conjunctivitis

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1 Do you have the following symptoms repeatedly in the past 12 months？ I Yes  II No （If no, go to next section）

1 Yes 2 No

Eyes itch  

Eyes red  

Tearing  

2 In what occasion did the symptoms occur?

Asthma

1 Have you ever been diagnosed with asthma? I Yes  II No 

If the answer was yes, then the respondent needed to answer Question 2:

2 Have you had wheezing or whistling in the chest in the past 12 months?

I Yes  II No 

Related symptoms Do you have the following symptoms in the past 12 months?

Symptoms Yes

III No I Perennial/Chronic II Occasional

Fatigue ≥6M  <6M 

Sleepy ≥1M(everyday)  <1M  

Mouth ulcer ≥3 times  <3 times  

Diarrhea >4W  ≤4W  

Constipation ≥6M  <6M 

Abdominal pain ≥2M(more than

once a week)  <2M  

Medical history

1Have you ever had the following diseases? (Diagnosed by a physician)

Diagnosed disease 1Yes 2 No

Hypertension  

Heart disease  

Diabetes  

Apoplexy  

Eczema  

Food allergy  

Drug allergy  

2 Have you ever had the history of surgery? (If yes, please indicate.) I Yes  II No 

3 Have you ever had the history of vaccination allergy? (If yes, please indicate.) I Yes  II No  III Unknown 

4 Do you use antibiotics frequently in the past 2 years? (≥3 times per year and ≥3

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days each time) I Yes  II No 

Risk factors

1Do your family members who are related to you in blood had these allergic diseases?

2 Do you have a pet dog or cat in your house? I Yes  II No  3What was the main heating fuel used in your house?

I Central heating  II Coal heating  III Wood heating  IV Others  4 What is the usual duration of your outdoor activities per day?

I <1 Hours  II 1-2 Hours  III 2-3 Hours  IV 3-4 Hours  V >4 Hours  5 Have you ever smoked any tobacco?

I Never smoking  II Now smoking  III Ever smoking  Diagnosis and treatment of diseases 1 Have you been to the hospital for any of the following disease？

Rhinitis I Yes  II No  Conjunctivitis I Yes  II No  Asthma I Yes  II No  Urticaria I Yes  II No  2.What kind of treatment have you had?

Drugs Yes No Invali

d

Symptom s improved

Cure Antihistamines (chlorphenamine, etc.)

Mast cell membrane stabilizer (ketotifen, etc.)

Theophylline Glucocorticoid

Other ((If yes, please indicate)

Signature of interviewer________

1Yes 2No 3Unknown

Grandfather   

Grandmother   

Material grandfather   

Material grandmother   

Father   

Mother   

Brother   

Sister   

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Date: ________