Supplementary File8. Numeric values corresponding to Figure2 of the main manuscript.
Proportion of use of different hormone therapy drug types over time in A) the cardiovascular disease and breast cancer sub-populations and B) the general UK female population
Supplementary Table6. Hormone therapy use in the general UK female population stratified by drug type from 1996/1997 to 2014/2015
Years Number of ETa users (%)
Number of EPTb users (%)
Number of tibolone users (%)
Number of mixed users (%) 1996/1997 80,813 (8.4) 83,477 (8.7) 7857 (0.8) 7887 (0.8) 1998/1999 90,758 (8.7) 94,338 (9.0) 9536 (0.9) 8827 (0.8) 2000/2001 99,181 (8.9) 104,990 (9.4) 11,709 (1.1) 10,296 (0.9) 2002/2003 99,269 (8.4) 95,701 (8.1) 13,166 (1.1) 10,746 (0.9) 2004/2005 84,353 (6.9) 55,999 (4.6) 9434 (0.8) 6527 (0.5) 2006/2007 77,315 (6.2) 42,908 (3.4) 6970 (0.6) 5431 (0.4) 2008/2009 74,362 (6.0) 36,210 (2.9) 5482 (0.4) 4680 (0.4) 2010/2011 71,780 (5.9) 31,979 (2.6) 4354 (0.4) 4523 (0.4) 2012/2013 66,575 (5.8) 28,688 (2.5) 3482 (0.3) 4076 (0.4) 2014/2015 56,290 (5.6) 25,015 (2.5) 2640 (0.3) 3468 (0.4)
aET: estrogen therapy
bEPT: estrogen plus progestogen therapy
Supplementary Table7. Hormone therapy use in cardiovascular disease patients stratified by drug type from 1996/1997 to 2014/2015
Years Number of ETa users (%)
Number of EPTb users (%)
Number of tibolone or mixed users (%) 1996/1997 5541 (8.1) 2765 (4.0) 824 (1.2) 1998/1999 6455 (8.5) 3359 (4.4) 985 (1.3) 2000/2001 7342 (9.0) 3869 (4.8) 1238 (1.5) 2002/2003 7585 (9.1) 3758 (4.5) 1350 (1.6) 2004/2005 5913 (7.2) 1907 (2.3) 771 (0.9) 2006/2007 5178 (6.5) 1175 (1.5) 509 (0.6)
2008/2009 4847 (6.5) 856 (1.2) 347 (0.5)
2010/2011 4474 (6.5) 695 (1.0) 272 (0.4)
2012/2013 4055 (6.5) 603 (1.0) 194 (0.3)
2014/2015 3285 (6.2) 474 (0.9) 174 (0.3)
aET: estrogen therapy
bEPT: estrogen plus progestogen therapy
Supplementary Table8. Hormone therapy use in breast cancer patients stratified by drug type from 1996/1997 to 2014/2015
Years Number of ETa users (%)
Number of EPTb users (%)
Number of tibolone or mixed users (%)
1996/1997 984 (5.1) 531 (2.8) 118 (0.6)
1998/1999 1153 (5.0) 682 (3.0) 164 (0.7)
2000/2001 1378 (5.1) 812 (3.0) 259 (1.0)
2002/2003 1570 (5.1) 894 (2.9) 316 (1.0)
2004/2005 1583 (4.6) 556 (1.6) 241 (0.7)
2006/2007 1677 (4.4) 422 (1.1) 190 (0.5)
2008/2009 1713 (4.3) 364 (0.9) 137 (0.3)
2010/2011 1673 (4.0) 308 (0.7) 121 (0.3)
2012/2013 1676 (4.1) 290 (0.7) 100 (0.2)
2014/2015 1370 (3.6) 220 (0.6) 61 (0.2)
aET: estrogen therapy
bEPT: estrogen plus progestogen therapy