Supplemental Digital Content Table 2. Prevalence of symptom severity at CaD baseline (n=20,050) and stratified by No. of moderate or severe symptoms.
Number of moderate or severe symptoms
2+ 1 None Total
aSymptom Severity N (%) N (%) N (%) N (%)
Hot Flashes None
4597 (68.0) 6038 (84.4) 4712 (87.0)
15837 (79.1)
Mild 1239 (18.3) 1072 (15.0) 707 (13.0) 3157 (15.8)
Moderate/Severe 924 (13.7) 48 (0.7) 0 (0) 1033 (5.2)
Night Sweats
None 4105 (60.7) 5827 (81.4)
4651 (85.8)
15047 (75.2)
Mild 1581 (23.4) 1289 (18.0) 768 (14.2) 3791 (18.9)
Moderate/Severe 1074 (15.9) 42 (0.6) 0 (0) 1181 (5.9)
Dizziness None
4605 (68.1) 6181 (86.4) 4900 (90.4)
16189 (81.0)
Mild 1632 (24.1) 942 (13.2) 519 (9.6) 3220 (16.1)
Moderate/Severe 523 (7.7) 35 (0.5) 0 (0) 589 (2.9)
Heart racing or skipping beats None
4429 (65.5) 5947 (83.1) 4689 (86.5)
15551 (77.8)
Mild 1596 (23.6) 1162 (16.2) 730 (13.5) 3605 (18.0)
Moderate/Severe 735 (10.9) 49 (0.7) 0 (0) 829 (4.1)
Tremors None
5984 (88.5) 6888 (96.2) 5308 (98.0)
18796 (93.9)
Mild 565 (8.4) 253 (3.5) 111 (2.0) 974 (4.9)
Moderate/Severe 211 (3.1) 17 (0.2) 0 (0) 238 (1.2)
Restless and fidgety None
3205 (47.4) 5153 (72.0) 4428 (81.7)
13170 (65.9)
Mild 2538 (37.5) 1981 (27.7) 991 (18.3) 5711 (28.6)
Moderate/Severe 1017 (15.0) 24 (0.3) 0 (0) 1097 (5.5)
Feeling tired
None 253 (3.7) 894 (12.5) 1149 (21.2) 2371 (11.9)
Mild
2395 (35.4) 5739 (80.2) 4270 (78.8)
12795 (64.0)
Moderate/Severe 4112 (60.8) 525 (7.3) 0 (0) 4834 (24.2)
Difficulty concentrating None
3156 (46.7) 5427 (75.8) 4574 (84.4)
13509 (67.8)
Mild 2785 (41.2) 1714 (23.9) 845 (15.6) 5523 (27.7)
Moderate/Severe 819 (12.1) 17 (0.2) 0 (0) 886 (4.4)
Forgetfulness
None 1608 (23.8) 3112 (43.5) 2936 (54.2) 7874 (39.4)
Mild
3455 (51.1) 3947 (55.1) 2483 (45.8)
10221 (51.1)
Moderate/Severe 1697 (25.1) 99 (1.4) 0 (0) 1890 (9.5)
Mood swings None
3020 (44.7) 5160 (72.1) 4351 (80.3)
12934 (64.7)
Mild 2614 (38.7) 1968 (27.5) 1068 (19.7) 5835 (29.2)
Moderate/Severe 1126 (16.7) 30 (0.4) 0 (0) 1219 (6.1)
Number of moderate or severe symptoms
2+ 1 None Total
aSymptom Severity N (%) N (%) N (%) N (%)
Vaginal or genital dryness None
4325 (64.0) 5549 (77.5) 4473 (82.5)
14760 (74.1)
Mild 1401 (20.7) 1422 (19.9) 946 (17.5) 3893 (19.5)
Moderate/Severe 1034 (15.3) 187 (2.6) 0 (0) 1270 (6.4)
Breast tenderness None
4647 (68.7) 5875 (82.1) 4638 (85.6)
15665 (78.3)
Mild 1530 (22.6) 1221 (17.1) 781 (14.4) 3660 (18.3)
Moderate/Severe 583 (8.6) 62 (0.9) 0 (0) 680 (3.4)
Headaches or migraines None
2398 (35.5) 4124 (57.6) 3525 (65.0)
10383 (52.0)
Mild 2498 (37.0) 2724 (38.1) 1894 (35.0) 7350 (36.8)
Moderate/Severe 1864 (27.6) 310 (4.3) 0 (0) 2253 (11.3)
Did you wake up several times
None 539 (8.0) 775 (10.8) 3094 (57.1) 4533 (22.7)
Mild 506 (7.5) 670 (9.4) 2325 (42.9) 3596 (18.0)
Moderate/Severe
5715 (84.5) 5713 (79.8) 0 (0)
11802 (59.2)
a
