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SDC.5. Plasma non-essential amino acids at 4 and 6 months of age in breast-fed infants or infants fed formula containing 0, 65 or 130 mg/L bovine osteopontin.

Variable F0 F65 F130 BF P-value,

all groups

P-value Formula-fed

vs Breast- fed

P-value, all formula

groups Taurine

4 months 0.100 ± 0.020 0.095 ± 0.034 0.11 ± 0.04 0.10 ± 0.04 0.5481 0.6456 0.3962

6 months 0.10 ± 0.03 0.087 ± 0.051 0.091 ± 0.025 0.086 ± 0.027 0.0804 0.5056 0.0449

Aspartate

4 months 0.013 ^a ± 0.004 0.010 ^ab ± 0.002 0.019 ^ab ± 0.024 0.011 ^b ± 0.004 0.0057 0.0201 0.0272 6 months 0.013 ^a ± 0.005 0.010 ^ab ± 0.002 0.010 ^a ± 0.003 0.008 ^b ± 0.002 0.0001 0.0001 0.0318 Asparagine

4 months 0.033 ± 0.008 0.042 ± 0.015 0.034 ± 0.010 0.039 ± 0.012 0.0639 0.2528 0.0536 6 months 0.028 ^b ± 0.006 0.055 ^a ± 0.020 0.033 ^b ± 0.011 0.044 ^a ± 0.015 <.0001 0.0036 <.0001 Serine

4 months 0.16 ^b ± 0.02 0.18 ^a ± 0.02 0.15 ^b ± 0.02 0.17 ^ab ± 0.02 0.0009 0.4095 0.0004 6 months 0.15 ^b ± 0.02 0.18 ^a ± 0.02 0.15 ^b ± 0.03 0.18 ^a ± 0.02 0.0013 0.0313 0.0044 Glutamate

4 months 0.16 ^a ± 0.02 0.15 ^ab ± 0.08 0.14 ^ab ± 0.04 0.13 ^b ± 0.06 0.0186 0.0207 0.0890 6 months 0.15 ^a ± 0.03 0.11 ^bc ± 0.04 0.13 ^b ± 0.02 0.10 ^c ± 0.02 <.0001 <.0001 <.0001 Glutamine

4 months 0.80 ^b ± 0.08 0.80 ^b ± 0.19 0.75 ^b ± 0.08 0.93 ^a ± 0.11 <.0001 <.0001 0.1521 6 months 0.75 ^b ± 0.09 0.80 ^ab ± 0.14 0.78 ^ab ± 0.13 0.85 ^a ± 0.11 0.0162 0.0057 0.2803

Variable F0 F65 F130 BF P-value, all groups

P-value Formula-fed

vs Breast- fed

P-value, all formula

groups

Glycine

4 months 0.22 ± 0.03 0.22 ± 0.03 0.21 ± 0.02 0.21 ± 0.02 0.0544 0.0935 0.0759

6 months 0.23 ^a ± 0.05 0.22 ^a ± 0.04 0.19 ^b ± 0.02 0.21 ^ab ± 0.03 0.0071 0.5915 0.0026 Alanine

4 months 0.43 ^a ± 0.09 0.41 ^ab ± 0.07 0.37 ^ab ± 0.07 0.37 ^b ± 0.07 0.0136 0.0261 0.0408 6 months 0.41 ^a ± 0.09 0.40 ^ab ± 0.06 0.34 ^b ± 0.08 0.34 ^b ± 0.05 0.0034 0.0231 0.0082 Tyrosine

4 months 0.077 ± 0.015 0.079 ± 0.015 0.075 ± 0.013 0.074 ± 0.014 0.7983 0.5964 0.6830 6 months 0.075 ± 0.017 0.078 ± 0.014 0.072 ± 0.017 0.070 ± 0.010 0.5467 0.3749 0.4820 Proline

4 months 0.20 ^a ± 0.03 0.20 ^ab ± 0.03 0.18 ^b ± 0.03 0.20 ^ab ± 0.05 0.0484 0.9058 0.0204

6 months 0.20 ± 0.04 0.20 ± 0.03 0.18 ± 0.04 0.19 ± 0.05 0.2906 0.6771 0.1626

Hydroxyproline

4 months 0.042 ^ab ± 0.004 0.044 ^a ± 0.005 0.038 ^b ± 0.008 0.044 ^ab ± 0.006 0.0219 0.2794 0.0160 6 months 0.034 ± 0.006 0.036 ± 0.006 0.033 ± 0.006 0.034 ± 0.005 0.4858 0.9307 0.3022

Data are expressed as mean ±SD; n=20/group