Supplemental Digital Content 1 for Psychosomatic Medicine
Rosano et al., Long-term Survival in Adults Aged 65 and Older With White Matter Hyperintensity:
Association With Performance on the Digit Symbol Substitution Test
Supplemental Table 1. Characteristics of participants with WMH> 3, stratified By DSST > 38 in 1992-1994. Mean (SD) or N (%).
Group 1 DSST>38 (n=685)
Group 2 DSST<38
(n=532)
Age-adjusted comparisons*
Biolo gicalmake -up
Age, years 77.62 (5.67) 74.76 (4.49)
Race, white 523 (76.91) 498 (94.14) <.0001
Sex , female 394 (57.52) 337 (63.35) .07
APOe4 allele 163 (26.21) 129 (25.65) .34
Ventricular grade>4 483 (70.51) 303 (57.06) .001
MRI markers Brain infarcts, presence 340 (49.64) 227 (42.67) .06 White matter hyperintensity
0-9, points 3.97 3.69 <.001
Presence of cardio- metabolicdiseases
Cardiovascular diseases 256 (37.37) 130 (24.44) <.001
Stroke 53 (9.25) 23 (4.36) .001
Myocardial infarction 70 (12.22) 48 (9.09) .05
Diabetes 115 (16.95) 65 (12.22) .006
Congestive heart failure 44 (7.68) 18 (3.41) .005
Hypertension
354 (52.76) 211 (40.11) <.0001
Subclinical/ physiological markers Subclinical vascular
conditions 529 (80.52) 353 (69.08) .001
HDL2, dl/L 53.51 (14.6) 53.43 (13.68) .76
Glucose1,4, dl/l 109.07 (33.88) 105.61 (28.74) .01 Pulse pressure3, mmHg 69.22 (18.29) 64.56 (18.12) .004 LV heart mass1, cm3 154.03 (32.58) 149.76 (30.07) .005
Cystatin C1, mg/dl 1.17 (0.3) 1.10 (0.28) .02
IL-61, mg/dl 2.47 (2.52) 1.93 (1.37) <.001
C-Reactive protein 1, mg/dl 5.54 (7.65) 4.81 (9.77) <.001
Psycho- Physical activity, Kcal1 1176.39 (1513.54) 1486.36 (1894.54)
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Supplemental Digital Content 1 for Psychosomatic Medicine
Rosano et al., Long-term Survival in Adults Aged 65 and Older With White Matter Hyperintensity:
Association With Performance on the Digit Symbol Substitution Test
Group 1 DSST>38 (n=685)
Group 2 DSST<38
(n=532)
Age-adjusted comparisons*
social/Lifestyle Income < $25,000 455 (71.99) 266 (53.09) <.001
Education>HS 247 (36.22) 304 (57.14) <.001
Smoking , current 61 (9.13) 39 (7.54) .02
Alcohol consumption 1.63 (4.94) 2.78 (6.38) <.001
3MS, points 85.63 (10.87) 94.35 (4.97) <.001
CES-D, points 6.21 (5.19) 4.67 (4.70) <.001
* ANOVA for continuous variables, chi-square for ordinal variables; age comparisons were not age-adjusted. 1Comparisons based on log-transformed values; 2comparisons adjusted for lipid medication use; 3 comparisons for glucose adjusted for insulin use; 4 comparisons adjusted for antihypertensive medications. Apoe4 = Apolipoprotein E4; CRP = C-reactive protein; DSST = Digit Symbol Substitution Test; HDL = high-density lipoprotein cholesterol; HS = high school;
IL-6 = interleukin-6; LV = left ventricular; 3MS = Mini-Mental Status Examination; MRI = magnetic resonance imaging; SD = standard deviation; WMH = white matter hyperintensities.
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