Supplemental Digital Content
Table S1. ICD-9-CM and ICD-10-CM Codes for the Conditions
Condition ICD-9-CM ICD-10-CM Role
HIV/AIDS
DX 042, 042.0, 042.1, 042.2, 042.9, 043, 043.1, 043.2, 043.3, 043.9, 044,
044.0, 044.9, 079.53, 795.71, V08 DX B20, B97.35, R75, Z21 Primary exposure
Depression
DX 296.20, 296.21, 296.22, 296.23, 296.24, 296.25, 296.26, 296.30, 296.31, 296.32, 296.33, 296.34, 296.35, 296.36, 296.51, 296.52, 296.53, 296.54, 296.55, 296.56, 296.60, 296.61, 296.62, 296.63, 296.64, 296.65, 296.66, 296.89, 298.0, 300.4, 309.1, 311
DX F31.30, F31.31, F31.32, F31.4, F31.5, F31.60, F31.61, F31.62, F31.63, F31.64, F31.75, F31.76, F31.77, F31.78, F31.81, F32.0, F32.1, F32.2, F32.3, F32.4, F32.5, F32.9, F33.0, F33.1, F33.2, F33.3, F33.40, F33.41, F33.42, F33.8, F33.9, F34.1, F43.21, F43.23
Exclusion criteria and outcome Depressive
disorder
DX 296.20, 296.21, 296.22, 296.23, 296.24, 296.25, 296.26, 296.30, 296.31, 296.32, 296.33, 296.34, 296.35, 296.36, 300.4, 311, V79.0
DX F32.0, F32.1, F32.2, F32.3, F32.4, F32.5, F32.89, F32.9, F33.0, F33.1, F33.2, F33.3, F33.40, F33.41, F33.42, F33.8, F33.9, F34.1
Exclusion criteria and outcome
Anxiety
DX 293.84, 300.00, 300.01, 300.02, 300.09, 300.10, 300.20, 300.21, 300.22, 300.23, 300.29, 300.3, 300.5, 300.89, 300.9, 308.0, 308.1, 308.2, 308.3, 308.4, 308.9, 309.81, 313.0, 313.1, 313.21, 313.22, 313.3, 313.82, 313.83
DX F06.4, F40.00, F40.01, F40.02, F40.10, F40.11, F40.210, F40.218, F40.220, F40.228, F40.230, F40.231, F40.232, F40.233, F40.240, F40.241, F40.242, F40.243, F40.248, F40.290, F40.291, F40.298, F40.8, F40.9, F41.0, F41.1, F41.3, F41.8, F41.9, F42, F42.2, F42.3, F42.4, F42.8, F42.9, F43.0, F43.10, F43.11, F43.12, F44.9, F45.8, F48.8, F48.9, F93.8, F99, R45.2, R45.5,
R45.6, R45.7 Exclusion
criteria
Bipolar
296.04, 296.05, 296.06, 296.10, 296.11, 296.12, 296.13, 296.14, 296.15, 296.16, 296.40, 296.41, 296.42, 296.43, 296.44, 296.45, 296.46, 296.50, 296.51, 296.52, 296.53, 296.54, 296.55, 296.56, 296.60, 296.61, 296.62, 296.63, 296.64, 296.65, 296.66, 296.7, 296.80, 296.81, 296.82, 296.89, 296.90, 296.99
DX F30.10, F30.11, F30.12, F30.13, F30.2, F30.3, F30.4, F30.8, F30.9, F31.0, F31.10, F31.11, F31.12, F31.13, F31.2, F31.30, F31.31, F31.32, F31.4, F31.5, F31.60, F31.61, F31.62, F31.63, F31.64, F31.70, F31.71, F31.72, F31.73, F31.74, F31.75, F31.76, F31.77, F31.78, F31.81, F31.89, F31.9, F33.8, F34.81, F34.89, F34.9, F39
Exclusion criteria
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Table S2a. Selection of the Cohorts
Step N Controls
*
All Medicare Beneficiaries, 1995-2015 5,236,625 -
Disabled/ESRD as original Medicare entitlement 1,096,130 -
Had HIV diagnosis 15,985 -
Had one year continuous A/B enrollment prior to diagnosis any time 14,166 -
Were 18 years or older at time of diagnosis 14,109 -
No missing matching variables 13,954 -
No mental disorder prior to diagnosis/index date 9,124 -
Matched to a non-HIV control 8,326 21,187
Final sample size excluding events at index date 8,196 20,778 Matching step 1 7,087 18,263 Matching step 2 1,109 2,515
*Controls were matched with cases by Medicare coverage start year or first year enrolled between 1995 and 2015, duration from the start year and index date in cases, age in years (at index date), sex, race, geographic region, and dual Medicare-Medicaid eligibility.
Table S2b. Number of Matched Cases by Steps and Number of Controls
Overall case:control ratio in final
sample: 1:2.6 Total N (%) Male Female
Incident HIV N (%)
Prevalent HIV N (%)
Incident HIV N (%)
Prevalent HIV N (%)
Total 8,196 (100) 1,743 (100) 4,482 (100) 695 (100) 1,276 (100)
Step 1 7,087 (86.5) 1,550 (88.9) 3,860 (86.1) 617 (88.8) 1,060 (83.1)
2 1,109 (13.5) 193 (11.1) 622 (13.9) 78 (11.2) 216 (16.9)
Number of controls
1 1,344 (16.4) 198 (11.4) 775 (17.3) 104 (15.0) 267 (20.9)
2 1,122 (13.7) 172 (9.9) 670 (15.0) 81 (11.7) 199 (15.6)
3 5,730 (69.9) 1,373 (78.8) 3,037 (67.8) 510 (73.4) 810 (63.5)
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Table S3. Outcome Within Five Years of Follow up by HIV Status and Sex among Medicare Enrollees Originally Qualified for Disability (1996-2015)
Male Female
Parameter Level
HIV- Incident HIV Prevalent HIV HIV- Incident HIV Prevalent HIV
N (%) N (%) N (%) N (%) N (%) N (%)
All 15,887 (100%) 1,743 (100%) 4,482 (100%) 4,891 (100%) 695 (100%) 1,276 (100%) Any
Depression Event by Five
Years
Censored 11,107 (69.9%) 896 (51.4%) 2,367 (52.8%) 3,109 (63.6%) 348 (50.1%) 704 (55.2%) Death 1,651 (10.4%) 312 (17.9%) 658 (14.7%) 425 (8.7%) 97 (14.0%) 160 (12.5%) Event 3,129 (19.7%) 535 (30.7%) 1,457 (32.5%) 1,357 (27.7%) 250 (36.0%) 412 (32.3%)
Table S4. Stratum Specific Subdistribution Hazard Ratios (95% CI) Over Follow-up Period by HIV Infection Status Among Male Medicare Enrollees Originally Qualified for Disability (1996-2015)
Variable Stratum Comparison Year 1 Year 2-3 Year 4-5
Age
18-39
Inc HIV vs HIV- 2.34 (1.90, 2.87) 1.65 (1.34, 2.04) 1.54 (1.19, 1.98) Inc HIV vs Prev HIV 1.03 (0.83, 1.27) 0.85 (0.68, 1.06) 1.04 (0.79, 1.37) Prev HIV vs HIV- 2.28 (2.01, 2.59) 1.96 (1.72, 2.22) 1.48 (1.26, 1.74) 40-49
Inc HIV vs HIV- 2.19 (1.81, 2.65) 1.55 (1.28, 1.89) 1.44 (1.13, 1.83) Inc HIV vs Prev HIV 1.23 (1.00, 1.51) 1.01 (0.82, 1.25) 1.25 (0.96, 1.62) Prev HIV vs HIV- 1.78 (1.57, 2.03) 1.53 (1.35, 1.74) 1.16 (0.99, 1.36) 50-59
Inc HIV vs HIV- 2.64 (2.11, 3.29) 1.86 (1.48, 2.35) 1.73 (1.33, 2.25) Inc HIV vs Prev HIV 1.34 (1.05, 1.71) 1.10 (0.86, 1.42) 1.36 (1.01, 1.82) Prev HIV vs HIV- 1.97 (1.68, 2.32) 1.69 (1.44, 1.98) 1.28 (1.06, 1.55) 60+
Inc HIV vs HIV- 1.67 (1.25, 2.23) 1.18 (0.87, 1.60) 1.10 (0.79, 1.52) Inc HIV vs Prev HIV 0.90 (0.63, 1.29) 0.74 (0.51, 1.08) 0.91 (0.61, 1.36) Prev HIV vs HIV- 1.86 (1.39, 2.48) 1.59 (1.19, 2.12) 1.20 (0.89, 1.63)
Index Year (Cohort Period)
1995-2000
Inc HIV vs HIV- 2.13 (1.76, 2.57) 1.51 (1.24, 1.83) 1.41 (1.11, 1.79) Inc HIV vs Prev HIV 0.95 (0.77, 1.16) 0.78 (0.64, 0.96) 0.97 (0.75, 1.26) Prev HIV vs HIV- 2.25 (1.99, 2.53) 1.92 (1.71, 2.17) 1.46 (1.25, 1.70) 2001-2005
Inc HIV vs HIV- 2.38 (1.92, 2.94) 1.68 (1.35, 2.11) 1.58 (1.22, 2.04) Inc HIV vs Prev HIV 1.28 (1.02, 1.61) 1.06 (0.83, 1.35) 1.31 (0.98, 1.74) Prev HIV vs HIV- 1.86 (1.59, 2.17) 1.59 (1.36, 1.86) 1.20 (1.00, 1.44) 2006-2010
Inc HIV vs HIV- 2.18 (1.75, 2.71) 1.54 (1.24, 1.93) 1.44 (1.12, 1.87) Inc HIV vs Prev HIV 1.33 (1.04, 1.71) 1.10 (0.86, 1.41) 1.37 (1.02, 1.83) Prev HIV vs HIV- 1.63 (1.38, 1.93) 1.40 (1.19, 1.64) 1.06 (0.87, 1.28) 2011-2015
Inc HIV vs HIV- 2.44 (1.84, 3.24) 1.73 (1.29, 2.32) 1.62 (1.16, 2.26) Inc HIV vs Prev HIV 1.21 (0.89, 1.64) 1.00 (0.73, 1.38) 1.24 (0.86, 1.79) Prev HIV vs HIV- 2.01 (1.67, 2.44) 1.73 (1.42, 2.10) 1.31 (1.04, 1.64)
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