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Supplemental Table 2. Demographic Features of AAV Patients from Latin America, Europe, Asia and Australia.

Pimentel -Quiroz et al [13]

(n=212)

Fernández -Ávila et al [10]

(n=106) Varga s et al [11]

(n=65 )

Cisterna s et al

[15]

(n=123)

Belem et al [22]

(n=295)

Pierini et al [8]

(n=47)

Pérez et al [12]

(n=41) d Paolini et al [16]

(n=38) d Cervera -Castillo et al [14]

(n=28) e Hinojosa

-Azaola et al [19]

(n=40) Flores- Suárez et al

[9]

(n=90) Berti et

al [68]

(n=58) Sada et al [29]

(n=125 ) f

Liu et al [30]

(n=209 ) g

Pamu k et al [72]

(n=45 )

Mahr et al [69]

(n=45)

h

Solans- Laqué et al [73]

(n=351 ) g

Ponte et al [74]

(n=92)

Mohamma d et al [70]

(n=128) i

Ormero d et al [28]

(n=54)

Gibson et al [75]

(n=101)

Continen

t America Asia Europe Australia

Country Peru Colombia Chile Chile

Brazil (southeas

t region)

Argentin a

Argentin a

Argentin

a Mexico Mexico Mexic

o USA (Olmste

d County)

Japan China Turke

y

France (Seine –St.

Denis County

)

Spain Portuga

l Sweden

Capital territory

– New South Wales

New Zealand (Canterbury

)

Female, n (%)

139

(65.6) 61 (57.5) 38

(58.5) 77 (62.6)

174

(59.0) 35 (74.5) 23 (56.1) 23 (60.5) 15 (53.6)

23 (57.5)

55 (61.1%

) 28 (48.3)

73 (58.4)

107 (51.2)

20 (44.4)

31 (45.6)

173 (49.3)

62

(67.4) 65 (50.8) 28

(51.9) 56 (55.5) Age at

diagnosis

a

59.2 (12.5)

56.0 (14.7)

53 .0 (45.0- 63.0) c

NR NR NR 53.5

(16.5) 54.1 (15.9)

50.1 (12.7)

53.0 (37.0- 58.0) c

42.0 (12.0)

61.1

(16.5) NR 59.5

(15.4) 52.6 (14.9)

50.3 (17.6)

55.6

(17.3) NR 67.6 (20.0-

62.0) c NR NR

MPA

n (%) 165

(77.8) b 48 (45.3) 30 (46.2)

65

(52.8) 42 (14.2) 28 (59.6) 17 (41.5) 15 (39.5) 0 5 (12.5) 10

(11.1) 28 (48.3)

78 (62.4)

172 (82.3)

15 (33.3)

16 (23.5)

167 (47.6)

22

(23.9) 65 (50.8) 16

(29.6) 28 (27.7) Female,

n (%) 117

(71.0) 28 (58.3) NR 44

(67.7) 27 (64.3) 21 (75%) 12 (70.6) 12 (80.0) 0 NR 9

(90.0) 15 (53.6)

43 (55.1)

88 (51.2)

10 (66.7)

11 (68.8)

83 (49.7)

17

(77.3) 35 (53.8) 7 (43.8) 11 (39.3) Age at

diagnosis 61.1 (11.5)

60.0

(14.7) NR 58.7

(15.5) 47.6 (15.5)

73.6 (13.2)

58.1 (18.8)

57.9

(16.1) 0 NR 47.0

(11.0) 67.7 (16.2)

71.1 (10.0)

61.7 (13.9)

61.5 (14.2)

60.2 (14.3)

63.8 (16.2)

60.7 (12.3)

70.0 (29.0- 92.0) c

63.0 (6.0- 75.0) c

70.5 (41.0- 94.0) c GPA

n (%) 42 (19.8) 56 (52.8) 35 (53.8)

58 (47.2)

200

(67.8) 19 (40.4) 20 (48.8) 23 (60.5) 20 (71.4)

35 (87.5)

74 (82.2)

23 (39.7)

33 (26.4)

37 (17.7)

30 (66.7)

21 (30.9)

184 (52.4)

41

(44.6) 63 (49.2) 38

(70.4) 73 (72.3) Female,

n (%) 21 (50.0) 32 (57.1) NR 33

(56.9) 119

(59.2) 14 (73.7) 9 (45.0) 11 (47.8) NR NR 44

(59.5) 12 (52.2)

21 (63.6)

19 (51.4)

10 (33.3)

9 (42.9)

90 (48.9)

25

(61.0) 30 (47.6) 21

(55.3) 45 (61.6) Age at

diagnosis 53.4 (14.1)

59.0

(14.8) NR 50.8

(14.0) 41.9 (14.9)

69.8 (11.3)

52.1 (16.0)

55.1

(16.1) NR NR 42.0

(12.0) 56.1 (15.1)

63.6 (12.6)

51.5 (17.5)

49.8 (13.3)

50.6 (17.9)

49.9 (16.3)

50.0 (14.1)

67.6 (20.0- 84.0) c

55.0 (14.0- 78.0) c

66.0 (27.0- 91.0) c AAV: ANCA-associated vasculitis; MPA: Microscopic polyangiitis; GPA: Granulomatosis with polyangiitis; NR: Not reported.

a Mean and standard deviation, except where otherwise is indicated.

b Renal-limited vasculitis patients were included.

c Median and interquartile range.

d Renal-limited vasculitis were excluded.

e Eosinophilic granulomatosis with polyangiitis patients were included.

f Unclassifiable patients (n=31) were excluded.

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g Eosinophilic granulomatosis with polyangiitis patients were excluded.

h Polyarteritis nodosa patients (n=23) were excluded.

i Eosinophilic granulomatosis with polyangiitis and polyarteritis nodosa patients were excluded.

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