SUPPLEMENTAL 2. Comparison of demographics/characteristics between patients with and without disseminated intravascular coagulation.
Characteristic without DIC a
(n = 15)
with DIC a
(n = 34) P
Age (years), mean (SD) 64.9 (16.8) 63.4 (16.4) 0.77
Male sex, n (%) 13 (87) 19 (56) 0.04 b
Infected site, n (%) 0.42
Respiratory 3 (20) 7 (21)
Genitourinary 1 (7) 7 (21)
Skin and soft tissue 4 (27) 5 (15)
Liver/Bile duct/Pancreas 4 (27) 4 (12)
Other 3 (20) 11 (32)
CCI, median (IQR) 1 (0–2) 1 (0–1) 0.75
APACHE-II, mean (SD) 16.3 (7.9) 20.2 (9.0) 0.15 c
SOFA, median (IQR) 6 (5–13) 9 (6–12.25) 0.11
Complement component values
C3 (mg/dL), mean (SD) 95.7 (24.9) 70.4 (28.0) < 0.01 c
C4 (mg/dL), mean (SD) 26.3 (11.6) 21.1 (9.5) 0.11 c
CH 50 (U/mL), mean (SD) 37.8 (12.7) 30.8 (10.9) 0.06 c
SC5b-9 (ng/mL), median (IQR) 287.1 (206.4–330.5) 400.0 (288.2–596.8) 0.01 Interventions
Mechanical ventilation, n (%) 6 (40) 18 (53) 0.40 b
Renal replacement therapy, n (%) 2 (13) 11 (32) 0.15
Continuous catecholamine support n (%) 8 (53) 25 (74) 0.15
Noradrenaline, n (%) 8 (53) 25 (74) 0.15
Vasopressin, n (%) 3 (20) 12 (35) 0.23
Dobutamine, n (%) 0 6 (18) 0.10
Dopamine, n (%) 3 (20) 7 (21) 0.64
Adrenaline, n (%) 0 2 (6) 0.48
Length of hospitalization (days), median
(IQR) 26 (15–37) 23 (10–42) 0.61
Mortality
7 days, n (%) 0 3 (9) 0.32
28 days, n (%) 0 5 (15) 0.15
In-hospital, n (%) 2 (13) 6 (18) 0.22
Continuous variables are expressed as means (SD) for normally distributed variables and medians (IQR) for non-normally distributed variables. Comparisons between groups with DIC and without DIC were performed using Fisher’s exact test for categorical variables and the Mann–Whitney U test for continuous variables, unless otherwise indicated. Bold typeface indicates statistical
significance (P < 0.05).
SD, standard deviation; IQR, interquartile range; CCI, Charlson comorbidity index; APACHE-II, Acute Physiology and Chronic Health Evaluation-II; SOFA, Sequential Organ Failure Assessment;
SC5b-9, soluble C5b–9; ISTH, International Society on Thrombosis and Haemostasis; DIC, disseminated intravascular coagulation; RRT, renal replacement therapy; LOS, length of stay
a