Supplemental Digital Content Table 1. Canadian Classification Index codes that denote ileostomy formation with or without bowel resection, ileostomy formation, and ileostomy reversal
CCI Codes that denote ileostomy
formation CCI Codes that denote bowel resection CCI Codes that denote ileostomy
reversal 1.NK.77.EN: Laparoscopic
enterostomy
1.NK.77.RR: Open enterostomy 1.NK.77.RR-XX-G: Open continent ileostomy
1.NM.89.DX: Laparoscopic excision total large intestine with stoma formation and distal closure 1.NM.89.TF: Open excision total large intestine with stoma formation and distal closure
1.NK.87.DX: Laparoscopic excision partial small intestine with stoma formation and distal closure 1.NK.87.TF : Open excision partial small intestine with stoma formation and distal closure
1.NK.87.DY: Laparoscopic excision partial small intestine with stoma formation and mucous fistula 1.NK.87.TG: Open excision partial small intestine with stoma formation and mucous fistula
1.NQ.89.RS-XX-G: Abdominal approach excision of rectum with continent ileostomy formation
1.NQ.89.LH-XX-G: Abdominoperineal approach excision of rectum with continent ileostomy formation
1.NM.87.DA: Laparoscopic simple excision of large intestine 1.NM.87.LA: Open simple excision of large intestine
1.NM.87.DF: Laparoscopic excision partial large intestine with colocolostomy 1.NM.87.RN: Open excision partial large intestine with colocolostomy
1.NM.87.DE: Laparoscopic excision partial large intestine with colorectal anastomosis
1.NM.87.RD: Open excision partial large intestine with colorectal anastomosis 1.NM.87.DN: Laparoscopic partial excision of large intestine with
enterocolostomy
1.NM.87.RE: Open partial excision of large intestine with enterocolostomy 1.NM.89.DF: Laparoscopic excision total large intestine with ileorectal anastomosis
1.NM.89.RN: Open excision total large intestine with ileorectal anastomosis 1.NM.91.DF: Laparoscopic excision radical large intestine with colocolostomy anastomosis
1.NM.91.RN: Open excision radical large intestine with colocolostomy anastomosis
1.NM.91.DE: Laparoscopic excision radical large intestine with colorectal anastomosis
1.NM.91.RD: Open excision radical large intestine with colorectal anastomosis 1.NM.91.DN: Laparoscopic excision radical large intestine with
enterocolostomy
1.NM.91.RE: Open excision radical large intestine with enterocolostomy 1.NK.87.DA: Laparoscopic simple excision partial small intestine 1.NK.87.LA: Open excision partial small intestine
1.NK.87.DN: Laparoscopic excision partial small intestine with enterocolostomy
1.NK.87.RE: Open excision partial small intestine with enterocolostomy 1.NK.87.DP: Laparoscopic excision partial small intestine with
enteroenterostomy
1.NK.87.RF: Open excision partial small intestine with enteroesterostomy 1.NQ.87.RD: Open anterior excision partial rectum with colorectal anastomosis 1.NQ.87.DE: Laparoscopic excision partial rectum with colorectal anastomosis 1.NQ.87.PB: Per orifice excision partial rectum with colorectal anastomosis 1.NQ.89.SF: Anterior excision total rectum with coloanal anastomosis 1.NQ.89.GV: Combined endoscopic or abdominal with perineal approach excision total rectum with coloanal anastomosis
1.NQ.89.KZ: Abdominoperineal excision total of rectum with coloanal anastomosis
1.NK.82.EN: Open reattachment, small intestine, of ileostomy 1.NK.82.RR: Laparoscopic reattachment, small intestine, of ileostomy
CCI = Canadian Classification Index
Supplemental Digital Content Table 2. International Classification of Disease 10-CA codes that denote diagnoses of inflammatory bowel disease, colon cancer, and rectal or rectosigmoid cancer.
Inflammatory bowel disease Colon cancer Rectal cancer or rectosigmoid cancer
K51.0: Ulcerative pancolitis K51.2: Ulcerative proctitis K51.3: Ulcerative
rectosigmoiditis
K51.4: Ulcerative colitis with inflammatory polyps
K51.5: Ulcerative left sided colitis
K51.8: Other ulcerative colitis K51.9: Ulcerative colitis, unspecified
K50.0: Crohn’s disease of small intestine
K50.1: Crohn’s disease of large intestine
K50.8: Other Crohn’s disease K50.9: Crohn’s disease, unspecified
K52.3: Indeterminate colitis
C18.0: Malignant neoplasm of ceacum
C18.1: Malignant neoplasm of appendix
C18.2: Malignant neoplasm of ascending colon
C18.3: Malignant neoplasm of hepatic flexure
C18.4: Malignant neoplasm of transverse colon
C18.5: Malignant neoplasm of splenic flexure
C18.6: Malignant neoplasm of descending colon
C18.7: Malignant neoplasm of sigmoid colon
C18.8: Overlapping malignant lesions of the colon
C18.9: Malignant neoplasm of colon, unspecified
C19: Malignant neoplasm of rectosigmoid junction C20: Malignant neoplasm of rectum
Supplemental Digital Content Table 3. Ileostomy and formation and community-onset AKI across various time intervals for AKI ascertainment following hospital discharge
Ileostomy group
(n=4136) Reference group,
(n=15,753) Unadjusted OR
(95% CI) Adjusted* OR (95% CI) AKI within 7 days 63 (1.5%) 49 (0.3%) 4.96 (3.41 –
7.21) 4.86 (3.28 -
7.19) AKI within 1 month 286 (6.9%) 238 (1.5%) 4.84 (4.06 –
5.77) 4.99 (4.09 -
6.10) AKI within 3
months 630 (15.2%) 720 (4.6%) 3.75 (3.35 - 4.20) 4.08 (3.62 - 4.61) AKI within 6
months 879 (21.2%) 1273 (8.1%) 3.06 (2.79 –
3.37) 3.36 (3.04 -
3.71)
*Adjusted for age, sex, admission category (elective versus emergent or urgent), inpatient AKI (binary), eGFR, and Charlson comorbidities.
Supplemental Digital Content Table 4. Ileostomy reversal within 6 months and new-onset CKD
AKI* CKD** Unadjusted OR
for CKD (95%CI)
Adjusted OR for CKD (95% CI)***
Reference group No 437/11,531 (3.8%) Reference Reference Ileostomy without
reversal
78/1263 (6.2%) 1.67 (1.30 – 2.14) 2.39 (1.83 - 3.14)
Ileostomy with reversal
9/737 (1.2%) 0.31 (0.16 - 0.61) 0.55 (0.28 - 1.07)
Reference group Yes 59/466 (12.7%) Reference Reference
Ileostomy without reversal
50/184 (27.1%) 2.57 (1.68 - 3.93) 4.40 (2.71 - 7.15)
Ileostomy with reversal
25/115 (21.7%) 1.92 (1.14 – 3.22) 3.88 (2.15 - 7.01)
*History of community-onset AKI following index surgery
**Values shown represent n (number of CKD cases) / N (number of at risk patients in specified group) (%)
***Adjusted for age, sex, admission category (elective versus emergent or urgent), inpatient AKI (binary), eGFR, and Charlson comorbidities
Supplemental Digital Content Table 5. Ileostomy reversal within 9 months and new-onset CKD
AKI* CKD** Unadjusted OR
for CKD (95%CI)
Adjusted OR for CKD (95% CI)***
Reference group No 453/11,385 (4.0%) Reference Reference Ileostomy without
reversal
78/1211 (6.4%) 1.66 (1.30 - 2.13) 2.45 (1.87 - 3.22) Ileostomy with
reversal
25/1052 (2.3%) 0.57 (0.38 - 0.86) 0.97 (0.63 - 1.47) Reference group Yes 63/449 (14.0%) Reference Reference
Ileostomy without reversal
46/167 (27.5%) 2.33 (1.51 - 3.59) 3.93 (2.39 - 6.47) Ileostomy with
reversal
35/173 (20.2%) 1.55 (0.98 - 2.45) 2.65 (1.59 – 4.42)
*History of community-onset AKI following index surgery
**Values shown represent n (number of CKD cases) / N (number of at risk patients in specified group) (%)
***Adjusted for age, sex, admission category (elective versus emergent or urgent), inpatient AKI (binary), eGFR, and Charlson comorbidities