Appendix. PubMed/MEDLINE Search Strategy
Query
#1 "Brain Injuries"[MeSH] OR "Craniocerebral Trauma"[MeSH:NoExp] OR "Head Injuries, Closed"[MeSH] OR "Head Injuries, Penetrating"[MeSH] OR "Wounds and Injuries/blood"[MAJR] OR brain injur*[Title/Abstract] OR brain traum*[Title/Abstract] OR cerebral injur*[Title/Abstract] OR cerebral traum*[Title/Abstract] OR head
injur*[Title/Abstract] OR head traum*[Title/Abstract] OR intracerebral injur*[Title/Abstract] OR
intracranial injur*[Title/Abstract] OR intracranial traum*[Title/Abstract] OR tbi[Title/Abstract] OR tich[Title/Abstract]
OR trauma[title] OR traumatic brain[Title/Abstract] OR traumatic head[Title/Abstract] OR traumatic intracranial [Title/Abstract]
#2 "Craniotomy"[MAJR] OR "Decompressive Craniectomy"[MeSH] OR "Hematoma"[MeSH] OR "Hemorrhage"[MeSH]
OR “Intracranial Hemorrhages"[MeSH] OR "Neurosurgery"[MeSH] OR "Neurosurgical Procedures"[MeSH:NoExp]
OR "Ventriculostomy"[MeSH] OR bleeding complicat*[Title/Abstract] OR craniectom*[Title/Abstract] OR evd[Title/Abstract] OR evds[Title/Abstract] OR haematom*[Title/Abstract] OR hematom*[Title/Abstract] OR haemorrhag*[Title/Abstract] OR hemorrhag*[Title/Abstract] OR ich[Title/Abstract] OR intracerebral
bleed*[Title/Abstract] OR intracranial bleed*[Title/Abstract] OR (progression[Title/Abstract] AND
bleed*[Title/Abstract]) OR trepanning*[Title/Abstract] OR trephinat*[Title/Abstract] OR trephining[Title/Abstract] OR ventricular drain*[Title/Abstract] OR ventriculostom*[Title/Abstract]
#3 "Blood Coagulation Tests"[MeSH] OR "Blood Component Transfusion"[MeSH:NoExp] OR "Blood Platelets"[MeSH]
OR "Blood Transfusion"[MeSH:NoExp] OR "International Normalized Ratio"[MeSH] OR "Platelet Activation"[MeSH]
OR "Platelet Aggregation"[MeSH] OR "Platelet Function Tests"[MeSH] OR "Platelet Transfusion"[MeSH] OR
"Receptors, Purinergic P2Y12"[MeSH] OR blood product*[Title/Abstract] OR emergency reversal[Title/Abstract] OR inr[Title/Abstract] OR inrs[Title/Abstract] OR international normalized ratio[Title/Abstract] OR international normalized ratios[Title/Abstract] OR multiplate[Title/Abstract] OR pfa 100[Title/Abstract] OR pfa 100™[Title/Abstract] OR
pfa100[Title/Abstract] OR platelet administration[Title/Abstract] OR platelet function[Title/Abstract] OR platelet dysfunct*[Title/Abstract] OR platelet infus*[Title/Abstract] OR platelet inhibit*[Title/Abstract] OR platelet reactiv*[Title/Abstract] OR platelet volum*[Title/Abstract] OR platelet[Title] OR platelets[Title] OR platelets administration[Title/Abstract] OR posttransfus*[Title/Abstract] OR P2Y12[Title/Abstract] OR transfuse*[Title] OR verifynow[Title/Abstract] OR verifynow™[Title/Abstract] OR (platelets[Title/Abstract] AND
administered[Title/Abstract]) OR (platelet*[Title/Abstract] AND transfus*[Title/Abstract]) OR (revers*[Title/Abstract]
AND (platelet*[Title/Abstract] OR coagulopath*[Title/Abstract]))
#4 #1 AND #2 AND #3
#5 "Anticoagulants"[MeSH] OR "Anticoagulants" [Pharmacological Action] OR "Aspirin"[MeSH] OR
"Dipyridamole"[MeSH] OR "eptifibatide" [Supplementary Concept] OR "Platelet Aggregation Inhibitors"[MeSH] OR
"Platelet Aggregation Inhibitors" [Pharmacological Action] OR "Prasugrel Hydrochloride"[MeSH] OR “Purinergic P2Y Receptor Antagonists"[MeSH] OR "Purinergic P2Y Receptor Antagonists" [Pharmacological Action] OR
abciximab[Title/Abstract] OR acetylsalicylic acid[Title/Abstract] OR anti coagula*[Title] OR anti coagulation
therap*[Title/Abstract] OR anti platelet agent*[Title/Abstract] OR anti platelet therap*[Title/Abstract] OR anti platelets agent*[Title/Abstract] OR anticoagul*[Title] OR anticoagulated patient[Title/Abstract] OR anticoagulated
patients[Title/Abstract] OR anticoagulation therap*[Title/Abstract] OR antiplatelet*[Title] OR antiplatelet
agent*[Title/Abstract] OR antiplatelet associated[Title/Abstract] OR antiplatelet drug*[Title/Abstract] OR antiplatelet therap*[Title/Abstract] OR antiplatelet use[Title/Abstract] OR antithrombot*[Title] OR antithrombotic
agent*[Title/Abstract] OR antithrombotic medicat*[Title/Abstract] OR antithrombotic therap*[Title/Abstract] OR aspirin[Title/Abstract] OR brilinta[Title/Abstract] OR clopidogrel[Title/Abstract] OR coagulopath*[Title] OR
coumadin[Title/Abstract] OR dipyridamole[Title/Abstract] OR eptifibatide[Title/Abstract] OR plavix[Title/Abstract] OR prasugrel[Title/Abstract] OR pre injur*[Title/Abstract] OR preinjury*[Title/Abstract] OR ticagrelor[Title/Abstract]
#6 #1 AND #2 AND #5
#7 "Critical Care"[MeSH] OR "Critical Illness"[MeSH] OR "Intensive Care Units"[MeSH] OR "Trauma Centers"[MeSH]
OR critical[Title] OR critically ill*[Title] OR critically injur*[Title/Abstract] OR intensive[Title] OR icu[Title] OR icus[Title] OR neurocrit*[Title] OR trauma*[Title] OR trauma patient*[Title/Abstract]
#8 #3 AND #5 AND #7
#9 "Platelet Transfusion"[MAJR] OR platelet transfus*[Title]
#10 #7 AND #9
#11 "Craniotomy"[MAJR] OR "Decompressive Craniectomy"[MeSH] OR “Intracranial Hemorrhages"[MeSH] OR
"Neurosurgery"[MeSH] OR "Neurosurgical Procedures"[MeSH:NoExp] OR "Ventriculostomy"[MeSH] OR brain haematoma*[Title/Abstract] OR brain hematoma*[Title/Abstract] OR bleeding complicat*[Title/Abstract] OR brain haemorrhag*[ti] OR brain hemorrhag*[ti] OR cerebral haemorrhag*[Title/Abstract] OR cerebral
hemorrhag*[Title/Abstract] OR craniectom*[Title/Abstract] OR evd[Title/Abstract] OR evds[Title/Abstract] OR ganglia haemorrhag*[Title/Abstract] OR ganglia hemorrhag*[Title/Abstract] OR ganglionic hemorrhag*[Title/Abstract] OR haemorrhagic complication[Title/Abstract] OR hemorrhagic complications[Title/Abstract] OR ich[Title/Abstract] OR intracerebral bleed*[Title/Abstract] OR intracerebral haematoma*[Title/Abstract] OR intracerebral
hematoma*[Title/Abstract] OR intracerebral haemorrhag*[Title/Abstract] OR intracerebral hemorrhag*[Title/Abstract]
OR intracranial bleed*[Title/Abstract] OR intracranial haematoma*[Title/Abstract] OR intracranial
hematoma*[Title/Abstract] OR intracranial haemorrhag*[Title/Abstract] OR intracranial hemorrhag*[Title/Abstract] OR intraventricular haemorrhag*[Title/Abstract] OR intraventricular hemorrhag*[Title/Abstract] OR parenchymal
haemorrhag*[Title/Abstract] OR parenchymal hemorrhag*[Title/Abstract] OR posterior fossa haemorrhag*[Title/Abstract] OR posterior fossa hemorrhag*[Title/Abstract] OR postoperative
haemorrhag*[Title/Abstract] OR postoperative hemorrhag*[Title/Abstract] OR (progression[Title/Abstract] AND bleed*[Title/Abstract]) OR putaminal haemorrhag*[Title/Abstract] OR putaminal hemorrhag*[Title/Abstract] OR subarachnoid haemorrhag*[Title/Abstract] OR subarachnoid hemorrhag*[Title/Abstract] OR subdural
haematoma*[Title/Abstract] OR subdural hematoma*[Title/Abstract] OR trepanning*[Title/Abstract] OR trephining[Title/Abstract] OR trephinat*[Title/Abstract] OR ventricular drain*[Title/Abstract] OR
ventriculostom*[Title/Abstract]
#12 #1 OR #5 OR #11
#13 ("Blood Component Removal"[MeSH] AND ("Blood Platelets"[MeSH] OR platelet*[Title/Abstract])) OR “Platelet Transfusion"[MeSH] OR (apheresis[Title/Abstract] AND platelet*[Title/Abstract]) OR platelet
administration[Title/Abstract] OR platelet infus*[Title/Abstract] OR platelets administration[Title/Abstract] OR (platelet*[Title/Abstract] AND pheres*[Title/Abstract]) OR platelet transfus*[Title/Abstract] OR platelets
transfus*[Title/Abstract] OR (pooled[Title/Abstract] AND platelet*[Title/Abstract]) OR (thrombocyte[Title/Abstract]
AND (apheres*[Title/Abstract] OR pheres*[Title/Abstract])) OR thrombocytapheresis[Title/Abstract] OR
thrombocytopheresis[Title/Abstract] OR thrombophoresis[Title/Abstract] OR transfused platelet*[Title/Abstract] OR transfusion of platelet*[Title/Abstract]
#14 #12 AND #13
#15 #4 OR #6 OR #8 OR #10 OR #14
#16 "Humans"[MeSH]
#17 #15 AND #16
#18 "Animals"[MeSH] OR animal[Title] OR dog[Title] OR dogs[Title] OR mice[Title] OR murine[Title] OR rat[Title] OR rats[Title]
#19 #15 NOT #18
#20 #17 OR #19
#21 "1987/01/01"[PDAT] : "2019/03/04"[PDAT]
#22 #20 AND #21
