Metformin Use is Associated with Fewer Complications in Patients with Type-2 Diabetes Undergoing Total Knee Arthroplasty

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Wilson et al. (2021) | DOI: 10.2106/JBJS.20.01535

Metformin Use Is Associated with Fewer Complications in Patients with Type-2 Diabetes Undergoing Total Knee Arthroplasty. A Propensity Score-Matched Analysis

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Metformin Use is Associated with Fewer Complications in Patients with Type-2 Diabetes Undergoing Total Knee Arthroplasty

Diabetes is a risk factor for complications

of total knee arthroplasty

(TKA)

The link between TKA and use of metformin—the

first-line

treatment for type-2 diabetes—is

not known

Retrospective study using...

Patients using metformin showed...

Lower 1-year revision rates

Truven

MarketScan database

Using

metformin Not using

metformin

METFORMIN

Patients with type-2 diabetes undergoing TKA

90-day

outcomes 1-year

revision rates

Lower odds of periprosthetic joint infections

Metformin use is associated with lower odds of multiple postoperative complications including periprosthetic joint infections and deep vein thrombosis, as well as lower revision

rates in patients with type-2 diabetes undergoing TKA Less resource

utilization

Lower deep vein

thrombosis rates