eTable 1. Baseline Characteristics in propensity-score matched patients
Variable
Norepinephrine
(n=169)
Vasopressin (n=169)
P value
Age (year) 56.95±12.30 58.21±11.95 0.338
Gender(male/female) 120/49 115/54 0.555
Weight (kg) 68.77±15.83 67.90±15.74 0.613
Body surface area(m2) 1.77±0.45 1.76±0.58 0.775
Body mass index (kg/m2) 24.23±2.59 23.97±5.04 0.403
NYHA class (III /IV) 61/108 52/117 0.299
EuroSCORE 7.20±3.86 7.79±3.89 0.165
Previous Medical History
Acute Myocardial infarction (n,%) 85, 50.30% 92, 54.44% 0.446
Arrhythmia (n,%) 66, 39.05% 71, 42.01% 0.580
Diabetes Mellitus (n,%) 56, 33.14% 58, 34.32% 0.818
Chronic Renal Failure (n,%) 37, 21.89% 29, 17.16% 0.272
Hyperlipidemia (n,%) 31, 18.34% 44, 26.04% 0.098
Hypertension (n,%) 107, 63.33% 95, 56.21% 0.183
Liver Disease (n,%) 2, 1.18% 0 —
Smoking 61, 36.09% 50, 29.59% 0.203
Excessive alcohol use (n,%) 113, 66.86% 106, 62.72% 0.425
ACEI/ARB use (n,%) 86, 50.89% 77, 45.56% 0.327
Ca2+-Blocker use (n,%) 82, 48.52% 69, 40.83% 0.155
β-blocker use (n,%) 59, 34.91% 60, 35.50% 0.909
Statin use (n,%) 27, 15.98% 34, 20.12% 0.322
Preoperative LVEF (%) 30.51±5.18 30.43±4.79 0.879
Preoperative LVDd (mm) 74.41±9.09 73.63±9.92 0.451
PH evaluated by Echocardiogram 0.633
None 37, 21.89% 38, 22.48%
Mild (n,%) 35, 20.71% 38, 22.48%
Moderate (n,%) 57, 33.73% 57, 33.73%
Severe (n,%) 40, 23.67% 36, 21.31%
CPB time (minutes) 185.91±70.04 182.85±73.09 0.694
ACC time (minutes) 136(109-159) 133(118-214) 0.118
Surgical Procedures 0.725
On-Pump CABG (n,%) 30, 17.75% 29, 17.16% 0.865
Off-Pump CABG (n,%) 24, 14.20% 36, 21.30%
Valves (n,%) 84, 49.71% 77, 45.57%
CABG+ Valves (n,%) 24, 14.20% 24, 14.20%
Emergency (n,%) 7, 4.14% 3, 1.77%
NYHA: New York Heart Association CABG: Coronary Artery Bypass Grafting LVEF: Left Ventricular Ejection Fraction CPB: Cardiopulmonary Bypass ACC: Aortic Cross Clamp ARB: Angiotensin Receptor Blocker
PH：Pulmonary Hypertension Mean±SD Median (Interquartile Range)
ACEI: Angiotensin-Converting Enzyme Inhibitors COPD: Chronic Obstructive Pulmonary Disease LVDd: Left Ventricular End-Diastolic diameter
eTable2. Postoperative hemodynamic data in Propensity-matched Patients
Variable
Norepinephrine
(n=169)
Vasopressin (n=169)
P value
Arterial Lactate (mmol/L)
At the end of surgery (T0) 4.6(3.3-6.3) 4.5(3.3-6.1) 0.335
T6 3.2(2.0-3.7) 3.4(2.8-3.9) 0.002
T12 2.3(1.6-3.3) 3.0(2.0-3.5) 0.003
T24 1.5(1.4-1.9) 1.9(1.5-3.1) <0.001
VIS (maximum)
T0 34.28±8.85 21.59±9.31 <0.001
From T0 to T6 27.53±6.12 24.43±5.68 <0.001
From T6 to T12 22.60±4.23 27.12±5.16 <0.001
From T12 to T24 18.43±4.22 22.40±4.72 <0.001 MAP (mmHg)
T0 60.61±7.27 59.20±6.94 0.068
T1 71.01±6.70 67.68±5.12 <0.001
T6 73(70-78) 73(71-75) 0.237
T24 78(70-81) 74(71-78) 0.008
CI (L/min·m2)
T0 2.30±0.45 2.26±0.44 0.483
T1 2.73±0.51 2.46±0.50 <0.001
T6 2.59±0.45 2.58±0.46 0.030
T24 2.81±0.47 2.73±0.48 0.147
SVR (dynes·sec/cm5)
T0 716±84 699±97 0.087
T1 946±87 1057±97 <0.001
T6 998(940-1426) 1167(1127-1273) <0.001
T24 1138(1066-1420) 1176(1114-1304) 0.476
Fluid balance (ml)
IPO (PFB) 205(116-427) 280(85-443) 0.952
1st POD (PFB) 740(635-969) 829(679-999) 0.392
2nd POD (NFB) 410(333-489) 365(246-508) 0.137
MPAP at T0 (mmHg) 23.54±9.47 22.22±8.01 0.170
VIS: Vasoactive-Inotropic Score MAP: Mean Arterial Pressure MPAP: Mean Pulmonary Arterial Pressure ScvO2: Central venous oxygen saturation CI: Cardiac Index SVR: Systemic Vascular Resistance IPO: Immediate postoperative period POD: Postoperative day PFB: Positive fluid balance NFB: Negative fluid balance Median (Interquartile Range) Mean ± SD
eTable3. Postoperative vasoactive and inotropic management
Variable Norepinephrine
(n=169)
Vasopressin (n=169)
P value
Epinephrine use (n, %)
30 minutes 8, 4.73% 3, 1.77% 0.125
60 minutes 6, 3.55% 3, 1.77% 0.311
6 hours 0 0 —
12 hours 0 0 —
24 hours 0 0 —
Dopamine use (n, %)
30 minutes 130, 76.92% 143, 84.61% 0.073
60 minutes 130, 76.92% 143, 84.61% 0.073
6 hours 129, 76.33% 139, 82.25% 0.180
12 hours 97, 57.40% 125, 73.96% 0.002
24 hours 97, 57.40% 119, 70.41% 0.013
Dobutamine use (n, %)
30 minutes 25, 14.79% 21, 12.43% 0.526
60 minutes 25, 14.79% 18, 10.65% 0.253
6 hours 13, 7.69% 12, 7.10% 0.835
12 hours 11, 6.51% 6, 3.55% 0.213
24 hours 0 0 —
Milrinone use (n, %)
30 minutes 169, 100% 169, 100% —
60 minutes 169, 100% 169, 100% —
6 hours 148, 87.57% 156, 92.31% 0.526
12 hours 122, 72.19% 141, 83.43% 0.013
24 hours 105, 62.13% 133, 78.70% 0.001
Levosimendan use (n, %)
30 minutes 6, 3.55% 18, 10.65% 0.011
60 minutes 6, 3.55% 18, 10.65% 0.011
6 hours 6, 3.55% 18, 10.65% 0.011
12 hours 6, 3.55% 18, 10.65% 0.011
24 hours 0 0 —
eTable 4. Intraoperative variables in Propensity-matched Patients
Variable
Norepinephrine
(n=169)
Vasopressin (n=169)
P value
Epinephrine use (n, %) 29, 17.16% 19, 11.24% 0.119 Norepinephrine use (n, %) 72, 42.605 88, 52.71% 0.081
Vasopressin use (n, %) 9, 5.32% 4, 2.37% 0.157
Dopamine use (n, %) 135, 79.88% 142, 84.02% 0.322
Dobutamine use (n, %) 35, 20.71% 28, 16.56% 0.328
Milrinone use (n, %) 142, 84.02% 151, 89.35% 0.150
ACEI/ARB use (n,%) 3, 1.77% 0 0.082
β-blocker use (n,%) 40, 2.37% 55, 32.54% 0.070 RBC transfusion (n, %) 36, 21.30% 27, 15.98% 0.209
Initial ScvO2 (%) 65.91±4.18 66.39±4.93 0.342
Final ScvO2 (%) 68.84±5.29 68.65±5.60 0.754
Initial hematocrit (%) 40.06±3.73 40.46±4.01 0.347
Final hematocrit (%) 30.95±2.97 30.53±3.38 0.220
NYHA：New York Heart Association RBC: Red Blood Cell
ScvO2: Central venous oxygen saturation
CPB: Cardiopulmonary Bypass Initial: Beginning of surgery Mean ± SD
ACC: Aortic Cross Clamp Final: End of surgery Median (Interquartile Range)