1
Table S1: Outocme analysis after utilization of previously declined liver grafts compared to a low risk cohort of livers primarily accepted at our centre.
Outcome Parameter
Overall Declined
Livers n=206
Declined DBD n=141
Primarily accepted DBD
n=282
Declined DCD n=65
Primarily accepted
DCD n=65
P value
(declined DBD
vs. primarily accepted DBD)
P value (declined
DCD vs. primarily
accepted DCD)
INR day 1 1.6 (1.3-1.88) 1.5 (1.3-1.8) 1.5 (1.2-1.7) 1.6 (1.4-2.0) 1.6 (1.3-1.9) 0.956 0.475 Peak ALT (U/L) 845 (506-1468) 811 (436-1327) 850 (509-1462) 1014 (553-1758) 793 (443-1551) 0.653 0.403
Hospital Stay (days) 10.5 (7-16) 10 (7-15) 10 (7-14) 11 (7-17) 10 (7-14) 0.298 0.686
RRT (n/%) 43 (20.9%) 27 (19.1%) 46 (16.3%) 16 (24.6%) 13 (20%) 0.4960 0.6740
Highest Complication overall (Clavien Grading), any:
- Grade V - Grade IVb - Grade IVa - Grade IIIb - Grade IIIa - Grade II - Grade I
- No complications
141 (68.4%) 30 (14.6%)
0 46 (22.3%)
6 (2.9%) 29 (14.1%) 27 (13.1%) 5 (2.4%) 65 (31.6%)
97 (68.8%) 21 (14.9%)
0 29 (20.6%)
6 (4.3%) 16 (11.3%) 21 (14.9%) 4 (2.8%) 44 (31.2%)
181 (64.2%) 34 (12.1%)
0 5 (1.8%) 10 (3.55) 53 (18.8%) 72 (25.5%) 7 (2.5%) 101 (35.8%)
44 (67.7%) 7 (10.8%)
0 17 (26.2%)
0 13 (20%)
6 (9.2%) 1 (1.5%) 21 (32.2%)
55 (84.5%) 9 (13.8%)
0 12 (18.5%)
6 (9.2%) 21 (32.3%)
7 (10.7%) 0 10 (15.4%)
0.3852 0.4444 1.000 0.0001 0.7890 0.0519 0.0129 1.000 0.3852
0.0385 0.7903 1.000 0.3997 0.0277 0.1619 1.000 1.000 0.0385 Cause of Early Graft loss
(n/%):
- PNF - HAT
- Bleeding from conduit - Hemorrhagic necrosis - Veno-venous occlusion - PVT
- Sepsis
Cause of Late graft loss (n/%):
- HAT
- Ischemic cholangiopathy - Tumour recurrence - New Tumour occurrence - Chronic rejection
Other causes (Patient death) - Intracranial bleeding - Cardivascular events
5 (2.4%) 3 (1.5%) 1 (0.5%) 2 (1%) 1 (0.5%)
0 2 (1%) 3 (1.5%)
2 (1%) 4 (1.9%) 3 (1.5%)
0 8 (3.9%)
2 (1%) 6 (2.9%)
4 (2.8%) 0 1 (0.7%) 2 (1.4%) 1 (0.7%)
0 2 (1.4%) 3 (2.1%) 1 (0.7%) 3 (2.1%) 2 (1.4%)
0 8 (5.7%) 2 (1.4%) 6 (4.3%)
5 (1.8%) 6 (3.5%)
0 1 (0.4%) 1 (0.4%) 1 (0.4%) 5 (1.8%) 4 (1.4%) 1 (0.4%) 3 (1.1%) 3 (1.1%) 3 (1.1%) 11 (3.9%)
2 (0.7%) 2 (0.7%)
1 (1.5%) 3 (4.6%)
0 0 0 0 0 0 1 (1.5%) 1 (1.5%) 1 (1.5%)
0 0 0 0
1 (1.5%) 2 (3.1%) 1 (1.5%)
0 0 0 0 1 (1.5%) 2 (3.1%) 1 (1.5%) 1 (1.5%)
0 0 0 0
0.4890 0.1848 0.3333 0.2587 1.000 1.000 1.000 0.6905
1.000 0.4051
1.000 0.5540 0.4574 0.6035 0.0187
1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000
Retransplantation (n/%) 8 (3.9%) 6 (4.3%) 15 (5.3%) 2 (3.1%) 3 (4.6%) 0.8132 0.1848
2 Data presented as median and IQR or frequency in n/%, INR: International Normalized Ratio; ALT: Amino-Alanine-Transferase; RRT: Renal Replacement Therapy; PNF: Primary-Non- Function; HAT: Hepatic Artery Thrombosis; PVT: Portal Vein Thrombosis;
