Figure, Supplemental Digital Content 2. Association between percentage of mutations and distance to dysplasia for all UC Progressors with early-onset of disease and >8 years disease duration. Open circles: non- dysplastic distal biopsies; grey circles: non-dysplastic mid biopsies; black circles: non-dysplastic proximal biopsies;
red circles: dysplastic biopsies. Regression lines include all biopsies except dysplastic biopsies. A-C: patients with HGD/cancer in proximal colon; D-F: patients with HGD/cancer in mid colon; G-H: patients with HGD/cancer in distal colon. Patient PG5 (C) had proximal HGD but, unfortunately, no proximal biopsies were available for study. Patient PG15 (F) had a cancer in the mid colon, but poor mapping quality, so cm to dysplasia are approximate.
