Appendix 1
Medline search strategy for: Perioperative or Preoperative Antibiotics OR Bowel Preparation and Abdominal OR Colorectal Surgery and Postoperative C Difficile
Medline (Ovid)
# Searches
1 exp Digestive System Surgical Procedures/
2 exp Gastrointestinal Diseases/su [Surgery]
3
Laparotomy/ or metastasectomy/ or exp microsurgery/ or exp ostomy/ or reoperation/ or second‐look surgery/ or surgery, computer‐assisted/ or surgical procedures, elective/ or exp surgical procedures, minimally invasive/
4 specialties, surgical/ or colorectal surgery/ or general surgery/
5 exp Colorectal Surgery/
6 excis*.mp.
7 surgeon*.mp.
8 surger:.mp.
9 surgical:.mp.
10 anastomo*.mp.
11 colectom:.mp.
12 proctocolectom:.mp.
13 procto‐colectom:.mp.
14 "j‐pouch".mp.
15 coloplast:.mp.
16 resect:.mp.
17 laparotom:.mp.
18 laparoscop:.mp.
19 operat:.mp.
20 reoperat:.mp.
21 su.fs. ["Surgery" floating subheading]
22 (intestin* adj2 pouch??).mp.
23 (ileal adj2 pouch??).mp.
24 or/1‐23 [Surgery & related terms]
25 exp Gastrointestinal Diseases/
26 exp colorectal neoplasms/ or exp rectal neoplasms/ or anus neoplasms/ or anal gland neoplasms/
27 ((rectal or rectum) adj2 cancer*).mp.
28 (Adenocarcinom: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
29 (Adenom: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
30 (Cancer: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
31 (Carcinom: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
32 (Malignan: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
33 (Metasta: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
34 (Neoplas: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
35 (Tumor: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
36 (Tumour: adj3 (colorect: or colon: or rect: or intestine: or large bowel: or bowel: or anal or anus or perianal or peri‐anal or circumanal or sigmoid:)).mp.
37 exp Colonic Diseases/
38 exp Rectal Diseases/
39 mesorectal*.mp.
40 meso‐rectal*.mp.
41 colorectal*.mp.
42 colo‐rectal*.mp.
43 anorectal*.mp.
44 ano‐rectal*.mp.
45 rectosigmoid*.mp.
46 recto‐sigmoid*.mp.
47 rectal‐sigmoid*.mp.
48 (abdomin* adj3 surg*).mp.
49 (abdomen* adj3 surg*).mp.
50 (gastrointestin* adj3 surg*).mp.
51 (gastro‐intestin* adj3 surg*).mp.
52 (bowel? adj3 surg*).mp.
53 exp Abdomen/
54 exp Intestinal Diseases/
55 exp Stomach Diseases/
56 or/25‐55 [Colorectal Cancer & related terms]
57 24 and 56 [Surgery + Colorectal]
58 Clostridium difficile/
59 Clostridium Infections/
60 Enterocolitis, Pseudomembranous/
61 Clostridium difficile.mp,kw.
62 c difficile.mp,kw.
63 c diff.mp,kw.
64 pseudomembranous colitis.mp,kw.
65 pseudomembranous enteritis.mp,kw.
66 pseudomembranous enterocolitis.mp,kw.
67 antibiotic associated colitis.mp,kw.
68 Peptoclostridium.mp.
69 Pepto‐clostridium.mp.
70 ((post‐op* or postop*) adj2 diarrh?ea*).mp.
71 Surgical Wound Infection/
72 (surgical adj2 infect*).mp.
73 (incision?? adj2 infect*).mp.
74 (trocar? adj2 infect*).mp.
75 or/58‐74 [C Diff Infections Or Surgical Wound Infection ] 76 Antibiotic Prophylaxis/
77 Premedication/
78 exp Preoperative Care/
79 preoperative period/
80 (preop* or pre‐op* or presurg* or pre‐surg* or preprocedur* or pre‐procedur*).mp.
81 (premedicat* or pre‐medicat*).mp.
82 prophyla*.mp.
83 (before adj2 surgery).mp.
84 (before adj2 surgical*).mp.
85 (before adj2 operating).mp.
86 Perioperative Care/
87 Perioperative Period/
88 (perioperat* or peri‐operat* or peroperat*).mp.
89 or/76‐88 [ Preoperative & related terms ] 90 exp Anti‐Infective Agents/
91 exp Anti‐bacterial Agents/
92 antibacteri??.mp.
93 anti‐bacteri??.mp.
94 antibiotic*.mp.
95 anti‐biotic*.mp.
96 Anti‐Bacterial Agents.rw.
97 Anti‐Infective Agents.rw.
98 anti‐Infective agent?.mp.
99 antiinfective agent?.mp.
100 (antimicrobial* or anti‐microbial*).mp.
101 Neomycin/
102 Neomycin??.mp.
103 Kanamycin/
104 Kanamycin??.mp.
105 exp Erythromycin/
106 Erythromycin??.mp.
107 Metronidazole/
108 Metronidazole??.mp.
109 Ciprofloxacin/
110 (Ciprofloxacin?? or cipro).mp.
111 Levofloxacin/
112 Levofloxacin??.mp.
113 (intestin?? adj2 prep*).mp.
114 (bowel* adj2 prep*).mp.
115 or/90‐114 [ Preop Abx or Bowel Prep ]
116 57 and 75 and 89 and 115 [ GI Surgery + (C Diff OR Sx wound infection) + (((Preop or Periop) + Antibiotics) or Bowel Prep) ]
117 exp animals/ not (exp animals/ and humans/) 118 116 not 117
119 limit 116 to human 120 118 or 119
121 remove duplicates from 120