DISEASE AND DECLINES WITH ANTI-TB TREATMENT IN HIV-INFECTED
CHILDREN
FARIZ HIDAYAT
MEJESTHA ROULI PUSPITASARI
I
• Monocyte-Lymphocyte RatioC
• PCR using Xpert MTB/RIF
O
• MLR may be an useful diagnostic tool for TB in setting where respiratory-based microbiologic confirmation is inaccessible
Well covered
Methods Section Study Procedures (page 2)
1.1 The Nature of the testing being studied is clearly specified
Adequately addressed
Methods section Definition (page 2)
1.2 The test is compared with an appropriate gold standard
1.3 Where no gold standard exist, a validated reference standard is used as comparator
Well covered
Methods section Study Population (page 2)
1.4 Patients for testing are selected either as a consecutive series or randomly, form a clearly defined study population
Not addressed
1.5 The test and gold standard are measured independently (blind) of each other
Poorly addressed
Methods section Study Procedures (page 2)
time as possible
Poorly addressed
1.7 Results are reported for all patients that are entered into the study
Well covered.
Methods section Study Procedures (page 2)
1.8 A pre-test diagnosis is made and reported
+
Discussion page 5
2.1 How reliable are the conclusions of this study?
Yes.
Methods section Definition (page 2)
comparable with the patient group targeted by this guideline in terms of the proportion with the disease, or the proportion with severe versus mild disease
Results section Cohort Characteristic (page 3)
3.1 How many patients are included in this study?
The prevalence of TB are not stated in this study
3.2 What is the prevalence?
3.3 What are the main characteristics of the patient population?
Results (page 4)
Methods section Study Procedures (page 2)
3.4 What test is being evaluated in this study?
evaluated is compared?
Methods in section Study Procedures (page 2)
Discussions page 5
Discussions page 5
Results section MLR Diagnostic Utility (page 5)
3.9 What is the positive predictive value of the test being evaluated?
3.10 What is the negative predictive value of the test being evaluated?
Results section MLR Diagnostic Utility (page 5)
3.11 What are the likelihood ratios for the test being evaluated?
Results section MLR Diagnostic Utility (page 5)
The authors have no funding
No.
