38
REFERENCES
Abdullah, M., Desmarini, D., Meilaini, S., Sari, P., Yunaini, L., & Fadilah, F. (2019). The effect of ethanolic leaves extract of soursop (Annona muricata L.) on human colorectal cancer cell line:
cell viability and in silico study to cyclin D1 protein. Health Science Journal of Indonesia, 10(2), 96-102.
Abdullah, M., Sudoyo, A. W., Utomo, A. R., Fauzi, A., & Rani, A. A. (2012). Molecular profile of colorectal cancer in Indonesia: is there another pathway?. Gastroenterology and Hepatology from bed to bench, 5(2), 71.
Abylkassov, R., & Xie, Y. (2016). Role of Yes-associated protein in cancer: An update. Oncology Letters, 12(4), 2277-2282.
Adachi, Y., Yamamoto, H., Ohashi, H., Endo, T., Carbone, D. P., Imai, K., & Shinomura, Y. (2010). A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers. World journal of gastroenterology: WJG, 16(46), 5779.
Agu, K. C., Okolie, N. P., Falodun, A., & Engel-Lutz, N. (2018). In vitro anticancer assessments of Annona muricata fractions and in vitro antioxidant profile of fractions and isolated acetogenin (15-acetyl guanacone). Journal of Cancer Research and Practice, 5(2), 53-66.
Alizadeh, J., Zeki, A. A., Mirzaei, N., Tewary, S., Moghadam, A. R., Glogowska, A., ... & Xu, F. Y. (2017).
Mevalonate cascade inhibition by simvastatin induces the intrinsic apoptosis pathway via depletion of isoprenoids in tumor cells. Scientific reports, 7(1), 1-14.
American Cancer Society. (2018). Colorectal Cancer Stages.
Amour, B. S., Campbell, V. A., Crews, J. E., Malarcher, A., Maurice, E., & Richard, R. A. (2007). State level prevalence of cigarette smoking and treatment advice, by disability status, United States. Preventative Chronic Disease, 4(4), A86.
Arnold, M., Sierra, M. S., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2017). Global patterns and trends in colorectal cancer incidence and mortality. Gut, 66(4), 683-691.
Artanti, A. N., Astirin, O. P., Prayito, A., Fisma, R., & Prihapsara, F. (2018). Synergistic Cytotoxicity Effect by Combination Treatment of Polyketide Derivatives from Annona muricata Linn Leaves and Doxorubicin as Potential Anticancer Material on Raji Cell Line. In IOP Conference Series: Materials Science and Engineering (Vol. 333, No. 1, p. 012067). IOP Publishing.
Awad, M. G., Ali, R. A., Abd El-Monem, D. D., & El-Magd, M. A. (2020). Graviola leaves extract enhances the anticancer effect of cisplatin on various cancer cell lines. Molecular & Cellular Toxicology, 1-15.
Baas, J. M., Krens, L. L., Bos, M. M., Portielje, J. E., Batman, E., van Wezel, T., ... & Gelderblom, H.
(2015). Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients. Anti-cancer drugs, 26(8), 872- 877.
Baas, J. M., Krens, L. L., Ten Tije, A. J., Erdkamp, F., van Wezel, T., Morreau, H., ... & Guchelaar, H. J.
(2015). Safety and efficacy of the addition of simvastatin to cetuximab in previously treated
39
KRAS mutant metastatic colorectal cancer patients. Investigational New Drugs, 33(6), 1242- 1247.
Beckwitt, C. H., Shiraha, K., & Wells, A. (2018). Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. PLoS One, 13(5).
Berg, K. C., Eide, P. W., Eilertsen, I. A., Johannessen, B., Bruun, J., Danielsen, S. A., ... & Myklebost, O.
(2017). Multi-omics of 34 colorectal cancer cell lines-a resource for biomedical studies.
Molecular cancer, 16(1), 1-16.
Bishehsari, F., Mahdavinia, M., Vacca, M., Malekzadeh, R., & Mariani-Costantini, R. (2014).
Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention. World journal of gastroenterology: WJG, 20(20), 6055.
Boman, B. M., Olive, M., Untawale, S., Blick, M., North, S., Gallick, G., ... & Thomas, G. (1990). The DiFi rectal carcinoma cell line from a familial adenomatous polyposis patient: An in vitro model system to study genetic changes in colorectal cancer. In Hereditary Colorectal Cancer (pp. 541-548). Springer, Tokyo.
Bonadonna, G., Monfardini, S., Marmont, A., Damasio, E., & Rossi, F. (1969). Cardiac toxicity of daunorubicin. The Lancet, 293(7599), 837-838.
Bourgine, J., Billaut-Laden, I., Happillon, M., Lo-Guidice, J. M., Maunoury, V., Imbenotte, M., & Broly, F. (2012). Gene expression profiling of systems involved in the metabolism and the disposition of xenobiotics: comparison between human intestinal biopsy samples and colon cell lines. Drug Metabolism and Disposition, 40(4), 694-705.
Brosens, L. A., Van Hattem, A., Hylind, L. M., Iacobuzio-Donahue, C., Romans, K. E., Axilbund, J., ... &
Giardiello, F. M. (2007). Risk of colorectal cancer in juvenile polyposis. Gut, 56(7), 965-967.
Bu, X. D., Li, N., Tian, X. Q., & Huang, P. L. (2011). Caco-2 and LS174T cell lines provide different models for studying mucin expression in colon cancer. Tissue and cell, 43(3), 201-206.
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R.
(2007). YAP1 increases organ size and expands undifferentiated progenitor cells. Current biology, 17(23), 2054-2060.
Cancer Genome Atlas Network. (2012). Comprehensive molecular characterization of human colon and rectal cancer. Nature, 487(7407), 330.
Canonici, A., Gijsen, M., Mullooly, M., Bennett, R., Bouguern, N., Pedersen, K., ... & Finn, R. (2013).
Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer. Oncotarget, 4(10), 1592.
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., ... & Zhang, Y. (2002). Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science, 298(5595), 1039- 1043.
Carmeliet, P., & Jain, R. K. (2011). Molecular mechanisms and clinical applications of angiogenesis.
Nature, 473(7347), 298-307.
Cassé, C. (2018). Molecular mechanisms of Annona muricata antiproliferative/anti-cancer properties. Biomed Genet Genomics. Volume 4(1): 1-4
40
Chang, H. L., Chen, C. Y., Hsu, Y. F., Kuo, W. S., Ou, G., Chiu, P. T., ... & Hsu, M. J. (2013). Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. Biochimica et Biophysica Acta (BBA)-General Subjects, 1830(8), 4053-4064.
Chen, M. J., Cheng, A. C., Lee, M. F., & Hsu, Y. C. (2018). Simvastatin induces G1 arrest by up‐
regulating GSK3β and down‐regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells. Journal of Cellular Physiology, 233(6), 4618-4625.
Cho, S. J., Kim, J. S., Kim, J. M., Lee, J. Y., Jung, H. C., & Song, I. S. (2008). Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis‐
associated colon cancer in mice. International journal of cancer, 123(4), 951-957.
Chu, E. (2007). Clinical colorectal cancer:“ode to 5-fluorouracil”. Clinical colorectal cancer, 6(9), 609.
Colussi, D., Brandi, G., Bazzoli, F., & Ricciardiello, L. (2013). Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. International journal of molecular sciences, 14(8), 16365-16385.
Coria-Téllez, A. V., Montalvo-Gónzalez, E., Yahia, E. M., & Obledo-Vázquez, E. N. (2018). Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry, 11(5), 662-691.
Denlinger, C. S., & Barsevick, A. M. (2009). The challenges of colorectal cancer survivorship. Journal of the National Comprehensive Cancer Network, 7(8), 883-894.
Desroches-Castan, A., Quélard, D., Demeunynck, M., Constant, J. F., Dong, C., Keramidas, M., ... &
Feige, J. J. (2015). A new chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras. Oncotarget, 6(7), 5382.
DiPiro, J. T., Schwinghammer, T. L., & Wells, B. G. (2014). A pathophysiologic approach.
Dobrzycka, M., Spychalski, P., Łachioski, A. J., Kobiela, P., Jędrusik, P., & Kobiela, J. (2018). Statins and colorectal cancer–a systematic review. Experimental and Clinical Endocrinology & Diabetes.
El‐Shami, K., Oeffinger, K. C., Erb, N. L., Willis, A., Bretsch, J. K., Pratt‐Chapman, M. L., ... & Stein, K. D.
(2015). American Cancer Society colorectal cancer survivorship care guidelines. CA: a cancer journal for clinicians, 65(6), 427-455.
Feng, S., Cong, S., Zhang, X., Bao, X., Wang, W., Li, H., ... & Qu, D. (2011). MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells.
Nucleic acids research, 39(15), 6669-6678.
Fluge, Ø., Gravdal, K., Carlsen, E., Vonen, B., Kjellevold, K., Refsum, S., ... & Otte, A. P. (2009).
Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis. British journal of cancer, 101(8), 1282-1289.
Fogh, J., Fogh, J. M., & Orfeo, T. (1977). One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute, 59(1), 221- 226.
Fogh, J., & Trempe, G. (1975). New human tumor cell lines. In Human tumor cells in vitro (pp. 115- 159). Springer, Boston, MA.
41
Frei E., Karon, M., Levin, R. H., Freireich, E. J., Taylor, R. J., Hananian, J., ... & Abir, E. (1965). The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. Blood, 26(5), 642-656.
Gauthaman, K., Richards, M., Wong, J., & Bongso, A. (2007). Comparative evaluation of the effects of statins on human stem and cancer cells in vitro. Reproductive biomedicine online, 15(5), 566- 581.
Gavamukulya, Y., Wamunyokoli, F., & El-Shemy, H. A. (2017). Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pacific journal of tropical medicine, 10(9), 835-848.
Ghalamfarsa, G., Hosseini, S. V., Hamidinia, M., Ghaderi, A., Mahmoudi, M., & Mojtahedi, Z. (2017).
Differential Immune Reactivity Pattern of SW48 and SW1116 Colorectal Cancer Cell Lines with Colorectal Cancer Patients Sera. Advanced biomedical research, 6.
Gong, J., Sachdev, E., Robbins, L. A., Lin, E., Hendifar, A. E., & Mita, M. M. (2017). Statins and pancreatic cancer. Oncology letters, 13(3), 1035-1040.
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002). Multidrug resistance in cancer: role of ATP–
dependent transporters. Nature Reviews Cancer, 2(1), 48-58.
Guinney, J., Dienstmann, R., Wang, X., De Reyniès, A., Schlicker, A., Soneson, C., ... & Bot, B. M.
(2015). The consensus molecular subtypes of colorectal cancer. Nature medicine, 21(11), 1350-1356.
Han, J. Y., Lee, S. H., Yoo, N. J., Hyung, L. S., Moon, Y. J., Yun, T., ... & Lee, J. S. (2011). A randomized phase II study of gefitinib plus simvastatin versus gefitinib alone in previously treated patients with advanced non–small cell lung cancer. Clinical Cancer Research, 17(6), 1553- 1560.
Hardwick, J. C., Van Den Brink, G. R., Bleuming, S. A., Ballester, I., Van Den Brande, J. M., Keller, J. J., ... & Peppelenbosch, M. P. (2004). Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology, 126(1), 111-121.
Hassanabad, A. F. (2019). Current perspectives on statins as potential anti-cancer therapeutics:
clinical outcomes and underlying molecular mechanisms. Translational lung cancer research, 8(5), 692.
Hewitt, R. E., McMarlin, A., Kleiner, D., Wersto, R., Martin, P., Tsoskas, M., ... & Stetler‐Stevenson, W.
G. (2000). Validation of a model of colon cancer progression. The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland, 192(4), 446-454.
Hindler, K., Cleeland, C. S., Rivera, E., & Collard, C. D. (2006). The role of statins in cancer therapy.
The oncologist, 11(3), 306-315.
Howe, J. R., Bair, J. L., Sayed, M. G., Anderson, M. E., Mitros, F. A., Petersen, G. M., ... & Vogelstein, B. (2001). Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nature genetics, 28(2), 184-187.
Howe, J. R., Mitros, F. A., & Summers, R. W. (1998). The risk of gastrointestinal carcinoma in familial juvenile polyposis. Annals of surgical oncology, 5(8), 751-756.
42
Huang, D. B., DuPont, H. L., Jiang, Z. D., Carlin, L., & Okhuysen, P. C. (2004). Interleukin-8 response in an intestinal HCT-8 cell line infected with enteroaggregative and enterotoxigenic Escherichia coli. Clinical and diagnostic laboratory immunology, 11(3), 548-551.
Hwang, K. E., Na, K. S., Park, D. S., Choi, K. H., Kim, B. R., Shim, H., ... & Kim, H. R. (2011). Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down- regulation of survivin. Investigational new drugs, 29(5), 945-952.
Ibáñez-Sanz, G., Guinó, E., Pontes, C., Quijada-Manuitt, M. Á., de la Peña-Negro, L. C., Aragón, M., ...
& Morros, R. (2019). Statin use and the risk of colorectal cancer in a population-based electronic health records study. Scientific reports, 9(1), 1-8.
Indrawati, L., Ascobat, P., Bela, B., Abdullah, M., Surono, I. S., & Pramono, S. (2016). Antiproliferative activity and caspase enhancement properties of Annona muricata leaves extract against colorectal cancer cells. Medical journal of Indonesia, 25(3), 136-42.
Indrawati, L., Bela, B., Abdullah, M., & Surono, I. S. (2016). The effect of a Annona muricata leaf extract on nutrition status and cytotoxicity in colorectal cancer: a randomized controlled trial. Asia Pacific journal of clinical nutrition.
International Agency for Research on Cancer. (2018). Global cancer observatory. World Health Organization. http://gco. iarc. fr. Accessed, 8.
Ishikawa, S., Hayashi, H., Kinoshita, K., Abe, M., Kuroki, H., Tokunaga, R., ... & Yagi, Y. (2014). Statins inhibit tumor progression via an enhancer of zeste homolog 2‐mediated epigenetic alteration in colorectal cancer. International journal of cancer, 135(11), 2528-2536.
Jang, H. J., Hong, E. M., Jang, J., Choi, J. E., Park, S. W., Byun, H. W., ... & Lee, J. (2016). Synergistic effects of simvastatin and irinotecan against colon cancer cells with or without irinotecan resistance. Gastroenterology research and practice, 2016.
Jang, H. J., Hong, E. M., Kim, M., Kim, J. H., Jang, J., Park, S. W., ... & Lee, J. (2016). Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. Oncotarget, 7(29), 46219.
Jang, H. J., Hong, E. M., Park, S. W., Byun, H. W., Koh, D. H., Choi, M. H., ... & Lee, J. (2016). Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. Oncology letters, 12(1), 250-256.
Jin, Y., Lu, J., Wen, J., Shen, Y., & Wen, X. (2015). Regulation of growth of human bladder cancer by miR-192. Tumor Biology, 36(5), 3791-3797.
Jin, Z., Selaru, F. M., Cheng, Y. A., Kan, T., Agarwal, R., Mori, Y., ... & Abraham, J. M. (2011).
MicroRNA-192 and-215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. Oncogene, 30(13), 1577-1585.
Karagkounis, G., DeVecchio, J., Ferrandon, S., & Kalady, M. F. (2018). Simvastatin enhances radiation sensitivity of colorectal cancer cells. Surgical endoscopy, 32(3), 1533-1539.
Karjalainen, E., & Repasky, G. A. (2016). Molecular changes during acute myeloid leukemia (AML) evolution and identification of novel treatment strategies through molecular stratification. In Progress in molecular biology and translational science (Vol. 144, pp. 383-436). Academic Press.
43
Kekelidze, M., D’Errico, L., Pansini, M., Tyndall, A., & Hohmann, J. (2013). Colorectal cancer: current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation. World journal of gastroenterology: WJG, 19(46), 8502.
Kim, Y., Kim, T. W., Han, S. W., Ahn, J. B., Kim, S. T., Lee, J., ... & Kang, W. K. (2019). A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-Line Chemotherapy in Metastatic Colorectal Cancer Patients. Cancer research and treatment: official journal of Korean Cancer Association, 51(3), 1128.
Kitabgi, P., Poustis, C., Granier, C., Van Rietschoten, Jurphaas., Rivier, J., Morgat, J. L., & Freychet, P.
(1980). Neurotensin binding to extraneural and neural receptors: comparison with biological activity and structure—activity relationships. Molecular pharmacology, 18(1), 11-19.
Kodach, L. L., Bleuming, S. A., Peppelenbosch, M. P., Hommes, D. W., van den Brink, G. R., &
Hardwick, J. C. (2007). The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway. Gastroenterology, 133(4), 1272-1281.
Kodach, L. L., Jacobs, R. J., Voorneveld, P. W., Wildenberg, M. E., Verspaget, H. W., van Wezel, T., ...
& Hardwick, J. C. (2011). Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathway. Gut, 60(11), 1544-1553.
Krens, L. L., Simkens, L. H., Baas, J. M., Koomen, E. R., Gelderblom, H., Punt, C. J., & Guchelaar, H. J.
(2014). Statin use is not associated with improved progression free survival in cetuximab treated KRAS mutant metastatic colorectal cancer patients: results from the CAIRO2 study.
PLoS One, 9(11), e112201.
Ku, J. L., & Park, J. G. (2005). Biology of SNU cell lines. Cancer research and treatment: official journal of Korean Cancer Association, 37(1), 1.
Kumar, R., & Yarmand-Bagheri, R. (2001). The role of HER2 in angiogenesis. In Seminars in oncology (Vol. 28, pp. 27-32). WB Saunders.
Lea, T. (2015). Caco-2 cell line. In The impact of food bioactives on health (pp. 103-111). Springer, Cham.
Leboeuf, M., Cavé, A., Bhaumik, P. K., Mukherjee, B., & Mukherjee, R. (1980). The phytochemistry of the Annonaceae. Phytochemistry, 21(12), 2783-2813.
Lee, J., Jung, K. H., Park, Y. S., Ahn, J. B., Shin, S. J., Im, S. A., ... & Hong, Y. S. (2009). Simvastatin plus irinotecan, 5-fluorouracil, and leucovorin (FOLFIRI) as first-line chemotherapy in metastatic colorectal patients: a multicenter phase II study. Cancer chemotherapy and pharmacology, 64(4), 657-663.
Lee, J., Lee, I., Han, B., Park, J. O., Jang, J., Park, C., & Kang, W. K. (2011). Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations. JNCI: Journal of the National Cancer Institute, 103(8), 674-688.
Lee, J. Y., Kim, M. S., Ju, J. E., Lee, M. S., Chung, N., & Jeong, Y. K. (2018). Simvastatin enhances the radiosensitivity of p53‑deficient cells via inhibition of mouse double minute 2 homolog.
International journal of oncology, 52(1), 211-218.
Lee, K. W., Lee, S. S., Kim, S. B., Sohn, B. H., Lee, H. S., Jang, H. J., ... & Lee, J. S. (2015). Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients. Clinical Cancer Research, 21(2), 357-364.
44
Lee, S. J., Lee, I., Lee, J., Park, C., & Kang, W. K. (2014). Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, potentiate the anti-angiogenic effects of bevacizumab by suppressing angiopoietin2, BiP, and Hsp90α in human colorectal cancer. British journal of cancer, 111(3), 497-505.
Lenaerts, K., Bouwman, F. G., Lamers, W. H., Renes, J., & Mariman, E. C. (2007). Comparative proteomic analysis of cell lines and scrapings of the human intestinal epithelium. BMC genomics, 8(1), 91.
Lesuffleur, T., Barbat, A., Dussaulx, E., & Zweibaum, A. (1990). Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells. Cancer research, 50(19), 6334-6343.
Liao, J. K., & Laufs, U. (2005). Pleiotropic effects of statins. Annu. Rev. Pharmacol. Toxicol., 45, 89- 118.
Li, G., Zheng, J., Xu, B., Ling, J., Qiu, W., & Wang, Y. (2017). Simvastatin inhibits tumor angiogenesis in HER2-overexpressing human colorectal cancer. Biomedicine & Pharmacotherapy, 85, 418- 424.
Li, H. R., Shagisultanova, E. I., Yamashita, K., Piao, Z., Perucho, M., & Malkhosyan, S. R. (2004).
Hypersensitivity of tumor cell lines with microsatellite instability to DNA double strand break producing chemotherapeutic agent bleomycin. Cancer research, 64(14), 4760-4767.
Lim, S. H., Kim, T. W., Hong, Y. S., Han, S. W., Lee, K. H., Kang, H. J., ... & Lee, J. (2015). A randomised, double-blind, placebo-controlled multi-centre phase III trial of XELIRI/FOLFIRI plus simvastatin for patients with metastatic colorectal cancer. British journal of cancer, 113(10), 1421-1426.
Lim, T., Lee, I., Kim, J., & Kang, W. K. (2015). Synergistic effect of simvastatin plus radiation in gastric cancer and colorectal cancer: implications of BIRC5 and connective tissue growth factor.
International Journal of Radiation Oncology* Biology* Physics, 93(2), 316-325.
Liu, B. S., Xia, H. W., Zhou, S., Liu, Q., Tang, Q. L., Bi, N. X., ... & Bi, F. (2018). Inhibition of YAP reverses primary resistance to EGFR inhibitors in colorectal cancer cells. Oncology reports, 40(4), 2171-2182.
Liu, M., Guo, S., & Stiles, J. K. (2011). The emerging role of CXCL10 in cancer. Oncology letters, 2(4), 583-589.
Lochhead, P., & Chan, A. T. (2013). Statins and colorectal cancer. Clinical gastroenterology and hepatology, 11(2), 109-118.
Lu, L., Huang, W., Hu, W., Jiang, L., Li, Y., Wu, X., ... & Li, M. (2019). Kruppel-like factor 2 mediated anti-proliferative and anti-metastasis effects of simvastatin in p53 mutant colon cancer.
Biochemical and biophysical research communications, 511(4), 772-779.
Luput, L., Licarete, E., Drotar, D. M., Nagy, A. L., Sesarman, A., Patras, L., ... & Tomuta, I. (2018). In vivo double targeting of C26 colon carcinoma cells and microenvironmental protumor processes using liposomal simvastatin. Journal of Cancer, 9(2), 440.
Luput, L., Sesarman, A., Porfire, A., Achim, M., Muntean, D., Casian, T., ... & Tomuta, I. (2020).
Liposomal simvastatin sensitizes C26 murine colon carcinoma to the antitumor effects of liposomal 5‐fluorouracil in vivo. Cancer Science, 111(4), 1344.
45
Malicki, S., Winiarski, M., Matlok, M., Kostarczyk, W., Guzdek, A., & Konturek, P. C. (2009). IL-6 and IL-8 responses of colorectal cancer in vivo and in vitro cancer cells subjected to simvastatin. J Physiol Pharmacol, 60(4), 141-146.
Marley, A. R., & Nan, H. (2016). Epidemiology of colorectal cancer. International journal of molecular epidemiology and genetics, 7(3), 105.
Martínez-Maqueda, D., Miralles, B., & Recio, I. (2015). HT29 cell line. In The Impact of Food Bioactives on Health (pp. 113-124). Springer, Cham.
Menter, D. G., Ramsauer, V. P., Harirforoosh, S., Chakraborty, K., Yang, P., Hsi, L., ... & Krishnan, K.
(2011). Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites. PloS one, 6(12), e28813.
Moghadamtousi, S. Z., Karimian, H., Rouhollahi, E., Paydar, M., Fadaeinasab, M., & Kadir, H. A.
(2014). Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. Journal of ethnopharmacology, 156, 277-289.
Moghadamtousi, S. Z., Rouhollahi, E., Karimian, H., Fadaeinasab, M., Firoozinia, M., Abdulla, M. A., &
Kadir, H. A. (2015). The chemopotential effect of Annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of acetogenin annomuricin E in HT-29 cells: a bioassay-guided approach. PLoS One, 10(4), e0122288.
Moghadasian, M. H. (1999). Clinical pharmacology of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Life sciences, 65(13), 1329-1337.
Mokhtari, R. B., Homayouni, T. S., Baluch, N., Morgatskaya, E., Kumar, S., Das, B., & Yeger, H. (2017).
Combination therapy in combating cancer. Oncotarget, 8(23), 38022.
Müller, M. F., Ibrahim, A. E., & Arends, M. J. (2016). Molecular pathological classification of colorectal cancer. Virchows Archiv, 469(2), 125-134.
Navabi, N., McGuckin, M. A., & Lindén, S. K. (2013). Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation. PloS one, 8(7).
Nyangale, E. P., Mottram, D. S., & Gibson, G. R. (2012). Gut microbial activity, implications for health and disease: the potential role of metabolite analysis. Journal of proteome research, 11(12), 5573-5585.
O'Keefe, S. J., & Greer, J. B. (2011). Microbial induction of immunity, inflammation, and cancer.
Frontiers in physiology, 1, 168.
Palko-Łabuz, A., Środa-Pomianek, K., Wesołowska, O., Kostrzewa-Susłow, E., Uryga, A., & Michalak, K. (2019). MDR reversal and pro-apoptotic effects of statins and statins combined with flavonoids in colon cancer cells. Biomedicine & Pharmacotherapy, 109, 1511-1522.
Pal, R., Wei, N., Song, N., Wu, S., Kim, R. S., Wang, Y., ... & Jacobs, S. A. (2018). Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies:
Treatment implications beyond KRAS mutations. PloS one, 13(8), e0200836.
46
Panina, Y., Germond, A., Masui, S., & Watanabe, T. M. (2018). Validation of common housekeeping genes as reference for qpcr gene expression analysis during iPS reprogramming process.
Scientific reports, 8(1), 1-8.
Paul-Samojedny, M., Kokocioska, D., Samojedny, A., Mazurek, U., Partyka, R., Lorenz, Z., & Wilczok, T. (2005). Expression of cell survival/death genes: Bcl-2 and Bax at the rate of colon cancer prognosis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1741(1-2), 25-29.
Pisanti, S., Picardi, P., Ciaglia, E., D’Alessandro, A., & Bifulco, M. (2014). Novel prospects of statins as therapeutic agents in cancer. Pharmacological research, 88, 84-98.
Qian, J. Q., Sun, P., Pan, Z. Y., & Fang, Z. Z. (2015). Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines.
International journal of clinical and experimental pathology, 8(9), 11934.
Qi, X. F., Kim, D. H., Yoon, Y. S., Kim, S. K., Cai, D. Q., Teng, Y. C., ... & Lee, K. J. (2010). Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells.
Toxicology letters, 199(3), 277-287.
Quinn, L. A., Moore, G. E., Morgan, R. T., & Woods, L. K. (1979). Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions.
Cancer research, 39(12), 4914-4924.
Rady, I., Bloch, M. B., Chamcheu, R. C. N., Banang Mbeumi, S., Anwar, M. R., Mohamed, H., ... &
Whitfield, G. K. (2018). Anticancer properties of Graviola (Annona muricata): a comprehensive mechanistic review. Oxidative medicine and cellular longevity, 2018.
Rawla, P., Sunkara, T., & Barsouk, A. (2019). Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors. , 14(2), 89.
Riganti, C., Doublier, S., Costamagna, C., Aldieri, E., Pescarmona, G., Ghigo, D., & Bosia, A. (2008).
Activation of nuclear factor-κB pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Molecular pharmacology, 74(2), 476-484.
Riganti, C., Miraglia, E., Viarisio, D., Costamagna, C., Pescarmona, G., Ghigo, D., & Bosia, A. (2005).
Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux. Cancer research, 65(2), 516-525.
Riganti, C., Orecchia, S., Pescarmona, G., Betta, P. G., Ghigo, D., & Bosia, A. (2006). Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. International journal of cancer, 119(1), 17-27.
Robertson, D. J., Riis, A. H., Friis, S., Pedersen, L., Baron, J. A., & Sørensen, H. T. (2010). Neither long- term statin use nor atherosclerotic disease is associated with risk of colorectal cancer.
Clinical Gastroenterology and Hepatology, 8(12), 1056-1061.
Rodriguez, V., Hart, J. S., Freireich, E. J., Bodey, G. P., McCredie, K. B., Whitecar JR, J. P., & Coltman JR, C. A. (1973). POMP combination chemotherapy of adult acute leukemia. Cancer, 32(1), 69-75.
Shojaei, F. (2012). Anti-angiogenesis therapy in cancer: current challenges and future perspectives.
Cancer letters, 320(2), 130-137.
47
Sideris, M., & Papagrigoriadis, S. (2014). Molecular biomarkers and classification models in the evaluation of the prognosis of colorectal cancer. Anticancer research, 34(5), 2061-2068.
Środa-Pomianek, K., Michalak, K., Palko-Łabuz, A., Uryga, A., Świątek, P., Majkowski, M., &
Wesołowska, O. (2019). The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells. International Journal of Molecular Sciences, 20(4), 955.
Środa-pomianek, K., Michalak, K., Palko-łabuz, A., Uryga, A., Szczęśniak-sięga, B., & Wesołowska, O.
(2019). Simvastatin Strongly Augments Proapoptotic, Anti-inflammatory and cytotoxic activity of oxicam derivatives in doxorubicin-resistant colon cancer cells. Anticancer research, 39(2), 727-734.
Sudoyo, A. W., Hernowo, B., Krisnuhoni, E., Reksodiputro, A. H., & Hardjodisastro, D. (2010).
Colorectal cancer among young native Indonesians: A clinicopathological and molecular assessment on microsatellite instability. Medical Journal of Indonesia, 19(4), 245-51.
Sorrentino, G., Ruggeri, N., Specchia, V., Cordenonsi, M., Mano, M., Dupont, S., ... & Rosato, A.
(2014). Metabolic control of YAP and TAZ by the mevalonate pathway. Nature cell biology, 16(4), 357-366.
Sulayman, A., & Muniroh, M. (2019). Effectivity Of Annona Muricata and Artemisinin Combined Therapy on Brain CXCL10 expression (Study in Swiss Mice During Severe Plasmodium Berghei ANKA Infection). Journal of Biomedicine and Translational Research, 5(2), 47-52.
Sun, S., Liu, J., Zhou, N., Zhu, W., Dou, Q. P., & Zhou, K. (2016). Isolation of three new annonaceous acetogenins from Graviola fruit (Annona muricata) and their anti-proliferation on human prostate cancer cell PC-3. Bioorganic & medicinal chemistry letters, 26(17), 4382-4385.
Talreja, O., & Cassagnol, M. (2019). Simvastatin.
Tomita, N., Jiang, W., Hibshoosh, H., Warburton, D., Kahn, S. M., & Weinstein, I. B. (1992). Isolation and characterization of a highly malignant variant of the SW480 human colon cancer cell line. Cancer research, 52(24), 6840-6847.
Tanaka, S., Kobayashi, W., Haraguchi, M., Ishihata, K., Nakamura, N., & Ozawa, M. (2016). Snail1 expression in human colon cancer DLD-1 cells confers invasive properties without N- cadherin expression. Biochemistry and biophysics reports, 8, 120-126.
Torres, M. P., Rachagani, S., Purohit, V., Pandey, P., Joshi, S., Moore, E. D., ... & Batra, S. K. (2012).
Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer letters, 323(1), 29-40.
Vazirinejad, R., Ahmadi, Z., Arababadi, M. K., Hassanshahi, G., & Kennedy, D. (2014). The biological functions, structure and sources of CXCL10 and its outstanding part in the pathophysiology of multiple sclerosis. Neuroimmunomodulation, 21(6), 322-330.
Wahab, A., Mariam, S., Jantan, I., Haque, M., & Arshad, L. (2018). Exploring the leaves of Annona muricata L. as a source of potential anti-inflammatory and anticancer agents. Frontiers in pharmacology, 9, 661.
Wang, F., Liu, W., Ning, J., Wang, J., Lang, Y., Jin, X., ... & Ma, J. (2018). Simvastatin suppresses proliferation and migration in non-small cell lung cancer via pyroptosis. International journal of biological sciences, 14(4), 406.
48
Wang, J., Li, G., Wang, Y., Tang, S., Sun, X., Feng, X., ... & Wang, M. (2015). Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF- 1α/VEGF secretion axis. Oncotarget, 6(42), 44579.
Wang, R. N., Green, J., Wang, Z., Deng, Y., Qiao, M., Peabody, M., ... & Idowu, O. (2014). Bone Morphogenetic Protein (BMP) signaling in development and human diseases. Genes &
diseases, 1(1), 87-105.
Wang, Y., Dai, H., Li, H., Lv, H., Wang, T., Fu, X., & Han, W. (2011). Growth of human colorectal cancer SW1116 cells is inhibited by cytokine-induced killer cells. Clinical and Developmental Immunology, 2011.
Wang, Z., Wu, Y., Wang, H., Zhang, Y., Mei, L., Fang, X., ... & Jiang, Y. (2014). Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proceedings of the National Academy of Sciences, 111(1), E89-E98.
Weiser, M. R. (2018). AJCC 8th edition: colorectal cancer. Annals of surgical oncology, 25(6), 1454- 1455.
Widjaja, S., & Yo, H. (2016). RM-049Colorectal cancer in Indonesia-a centre report. Annals of Oncology, 27(Suppl 2), ii97.
Xiong, S., Grijalva, R., Zhang, L., Nguyen, N. T., Pisters, P. W., Pollock, R. E., & Yu, D. (2001). Up- regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-β1- activated p38 signaling pathway enhances endothelial cell migration. Cancer research, 61(4), 1727-1732.
Yang, C., Gundala, S. R., Mukkavilli, R., Vangala, S., Reid, M. D., & Aneja, R. (2015). Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer. Carcinogenesis, 36(6), 656-665.
Yu, F. X., Meng, Z., Plouffe, S. W., & Guan, K. L. (2015). Hippo pathway regulation of gastrointestinal tissues. Annual review of physiology, 77, 201-227.
Zheng, X. F., Liu, K. X., Wang, X. M., Zhang, R., & Li, X. (2019). MicroRNA‑192 acts as a tumor suppressor in colon cancer and simvastatin activates miR‑192 to inhibit cancer cell growth.
Molecular medicine reports, 19(3), 1753-1760.
Zweibaum, A., Laburthe, M., Grasset, E., & Louvard, D. (2010). Use of cultured cell lines in studies of intestinal cell differentiation and function. Comprehensive physiology, 223-255.
