Table 1
Hazard Ratio for first fistula abscess or smaller CD surgical procedure since diagnosis
Family history Events
Person years
Crude HR (CI 2.5%-97,5%)
Adjusted**
HR (CI 2.5%-97,5%) p
Relative without IBD
698 53950 ref* ref* 0,9546CD relative
56 3831 1.19 (0.91 - 1.57) 0.95 (0.70 - 1.31)UC relative
38 2677 1.11 (0.80 - 1.53) 1.01 (0.69 - 1.47)CD or UC relative
94 6508 1.16 (0.93 - 1.43) 0.97 (0.76 - 1.25) 0,8361*The reference is CD cases of the same type without known IBD family members
** Stratified for birth year, date of diagnosis, and sex. Adjusted for family size and anti TNF-Alfa treatment
2 Table 2
Hazard Ratio for first UC related surgery
Family history
Years since
diagnosis Events
Person years
Crude*
HR (CI 2.5%-97,5%)
Adjusted**
HR (CI 2.5%-97,5%) p
Relative without IBD 0-15 1804 104164 ref* ref* 0,307
CD relative 0-15 59 2607 1.39 (1.07 - 1.80) 1.26 (0.93 - 1.70)
UC relative 0-15 127 7309 1.08 (0.90 - 1.30) 1.04 (0.85 - 1.28)
CD or UC relative 0-15 186 9916 1.16 (1.00 - 1.35) 1.10 (0.93 - 1.31) 0,2736
Hazard Ratio for first CD related surgery
Family history
Years since
diagnosis Events
Person years
Crude*
HR (CI 2.5%-97,5%)
Adjusted**
HR (CI 2.5%-97,5%) p
Relative without IBD 0-15 2366 40765 ref* ref* 0,1495
CD relative 0-2 80 773 0.84 (0.67 - 1.05) 0.83 (0.64 - 1.08)
CD relative 2-15 83 1951 1.48 (1.18 - 1.85) 1.30 (0.98 - 1.74)
UC relative 0-2 78 625 1.01 (0.81 - 1.27) 1.13 (0.86 - 1.48)
UC relative 2-15 36 1432 0.86 (0.62 - 1.21) 0.88 (0.59 - 1.31)
CD or UC relative 0-15 277 4781 1.02 (0.90 - 1.16) 1.02 (0.88 - 1.19) 0,7867
*The reference is IBD cases of the same type without known IBD family members
** Stratified for birth year, date of diagnosis, and sex. Adjusted for family size and anti TNF-Alfa treatment
3 Table 3
Hazard Rate for 2nd Major CD related surgery since diagnosis
Family history
Years since
diagnosis Events
Person years
Crude HR (CI 2.5%-97,5%)
Adjusted**
HR (CI 2.5%-97,5%) p
Relative without IBD 0-15 402 11996 ref* ref* 0,8895
CD relative 0-15 37 1078 1.07 (0.76 - 1.49) 1.11 (0.65 - 1.90)
UC relative 0-15 30 602 1.50 (1.03 - 2.17) 1.13 (0.54 - 2.35)
CD or UC relative 0-15 67 1680 1.22 (0.95 - 1.59) 1.12 (0.71 - 1.76) 0,6296
Hazard Rate for 3rd Major CD related surgery since diagnosis
Family history
Years since diagnosis Eve
nts
Person years
Crude HR (CI 2.5%-97,5%)
Adjusted**
HR (CI 2.5%-97,5%) Relative without IBD 0-15
62 1643 ref*
Lack of power
CD relative 0-15 3 147 0.54 (0.17 - 1.72)
Lack of power
UC relative 0-15 3 142 0.56 (0.18 - 1.79)
Lack of power
CD or UC relative 0-15 6 288 0.55 (0.24 - 1.27)
Lack of power
*The reference is IBD cases of the same type without known IBD family members
** Stratified for birth year, date of diagnosis, and sex. Adjusted for family size and anti TNF-Alfa treatment