C-10
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Ozonated Aloe vera Oil Effective Increased the Number of Fibroblasts and Collagen Thickening in the Healing Response of Full-Thickness Skin Defects
(Article) (Open Access), , , ,
Master Student of Biomedical Sciences, Faculty of Medicine, Diponegoro University, Semarang, Indonesia Department of Neurosurgery, Faculty of Medicine, Diponegoro University, Semarang, Indonesia Division of Physics, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia
Abstract
Objective. This study aimed to examine the effectiveness of ozonated Aloe vera oil on the wound healing response of full-thickness defect tissue in Sprague-Dawley rats, assessed by collagen thickness and the number of fibroblasts.
Methods. This was an experimental research method using control groups and treatment groups with a posttest only control group design. The results showed that collagen thickness in wounds tended to increase, assessed on day 3 and day 7 using Masson's trichrome staining and microscopic evaluation. Results. There was a significant difference in the number of fibroblasts between the two control and treatment groups on days 3 and 7 tested using one-way Kruskal- Wallis test, with a value of p=0.001p<0.05, resulting in a significant difference in wound size reduction between the groups. Further post hoc analysis using the Mann-Whitney test indicated a significant difference between the control groups and the treatment groups (P0, P1 versus P3, P4, P5, P8, P9, and P10) with a value of p=0.009p<0.05.
Conclusions. Ozonated Aloe vera oil is effective in increasing the healing response of full-thickness defects, leading to the increase in the number of fibroblasts and collagen thickening that in turn accelerates wound healing in Sprague- Dawley rats. © 2021 Ahsanu Taqwim Hidayat et al.
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Geoffrey, C., Victor, W., Thorne, C.H.
Wound healing: Normal and abnormal
(2014) Grabb Smithâ™s Plast. Surg.. . 7th ed. Philadelphia, PA, USA Lippincott Williams & Wilkins
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Open Access International Journal of Inflammation
Volume 2021, 2021, Article number 6654343
Taqwim Hidayat, A.a Thohar Arifin, M.a,b Nur, M.c Muniroh, M.a,d Susilaningsih, N.a,e
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Ozone | Ozonation | Chemonucleolysis
ISSN: 20908040 Source Type: Journal Original language: English
DOI: 10.1155/2021/6654343 Document Type: Article Publisher: Hindawi Limited
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25/03/2021 iji - About this journal | Hindawi
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International Journal of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on the molecular basis, cell biology and pharmacology of inflammation, including acute/chronic inflammation, mediators of inflammation, as well as cellular processes and molecular mechanisms involved in the production of inflammatory responses. The journal especially welcomes the submission of articles on anti-inflammatory drug development, trials and therapies.
Bibliographic information
ISSN: 2090-8040 (Print) ISSN: 2042-0099 (Online) DOI: 10.1155/8519
Open Access
International Journal of Inflammation is an open access journal. All articles are immediately available to read and reuse upon publication. More information about our Open Access policy can be found on our copyright page.
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Editorial enquiries should be directed to [email protected].
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Academic Editors
• Sandeep K. Arora, Chitkara University, India
• Istvan Boldogh, The University of Texas Medical Branch, USA
• Jean-Marc Cavaillon , Institut Pasteur, France
• Andrew S. Day , University of Otago (Christchurch), New Zealand
• Sarah Howie , University of Edinburgh, United Kingdom
• Kamyar Kalantar-Zadeh , University of California, Irvine, USA
• Wesam Kooti , Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
• Jian-Dong Li , Georgia State University, USA
• Howard Maibach, University of California, San Francisco, USA
• Han J. Moshage, University of Groningen, The Netherlands
• Yuji Naito, Kyoto Prefectural University, Japan
• B. L. Slomiany, University of Medicine and Dentistry of New Jersey, USA
• Cai Song, University of Prince Edward Island, Canada
• Saravanan Subramanian, Northwestern University, USA
• Marla R. Wolfson, Temple University, USA
• Hong Zan , University of Texas Health Science Center at San Antonio, USA
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25/03/2021 Table of Contents | International Journal of Inflammation | Hindawi
https://www.hindawi.com/journals/iji/contents/ 1/5
Table of Contents
International Journal of Inflammation - Volume 2021 - Article ID 6654343 - Research Article
Ozonated Aloe vera Oil Effective Increased the Number of Fibroblasts and Collagen Thickening in the Healing Response of Full-Thickness Skin Defects
Ahsanu Taqwim Hidayat | Muhamad Thohar Ari n | ... | Neni Susilaningsih
09 Feb 2021
PDF
International Journal of Inflammation - Volume 2021 - Article ID 6284987 - Review Article
Various Forms of Tuberculosis in Patients with Inflammatory Bowel Diseases Treated with Biological Agents
Adam Krusiński | Anna Grzywa-Celińska | ... | Janusz Milanowski
05 Jan 2021
PDF
International Journal of Inflammation - Volume 2020 - Article ID 8880879 - Research Article
The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis
Janisleya Silva Ferreira Neves | Jeane Eliete Laguila Visentainer | ... | Ana Maria Sell
08 Dec 2020
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25/03/2021 Table of Contents | International Journal of Inflammation | Hindawi
https://www.hindawi.com/journals/iji/contents/ 2/5
International Journal of Inflammation - Volume 2020 - Article ID 3503814 - Corrigendum
Corrigendum to “EOLA1 Inhibits Lipopolysaccharide-Induced Vascular Cell Adhesion Molecule-1 Expression by Association with MT2A in ECV304 Cells”
Weiling Leng | Xiaotian Lei | ... | Ziwen Liang
27 Sep 2020
PDF
International Journal of Inflammation - Volume 2020 - Article ID 9476326 - Research Article
Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population
L. Akhmaltdinova | V. Sirota | ... | A. Turmukhambetova
08 Sep 2020
PDF
International Journal of Inflammation - Volume 2020 - Article ID 8340195 - Research Article
The Effect of Lithium on Inflammation-Associated Genes in Lipopolysaccharide-Activated Raw 264.7 Macrophages
Raymond T. Makola | Vusi G. Mbazima | ... | Thabe M. Matsebatlela
25 Jul 2020
PDF
International Journal of Inflammation - Volume 2020 - Article ID 6947382 - Research Article
Prognostic Value of C-Reactive Protein to Albumin Ratio in Glioblastoma Multiforme Patients Treated with Concurrent Radiotherapy and
Temozolomide
Erkan Topkan | Ali A. Besen | ... | Ugur Selek
08 Jun 2020
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International Journal of Inflammation - Volume 2020 - Article ID 3254017 - Research Article
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Review Article
Various Forms of Tuberculosis in Patients with Inflammatory Bowel Diseases Treated with Biological Agents
Adam Krusi ´nski ,
1Anna Grzywa-Celi ´nska ,
1Katarzyna Szewczyk ,
2Luiza Grzycka-Kowalczyk,
3Justyna Emeryk-Maksymiuk ,
4and Janusz Milanowski
11Chair and Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Lublin, Poland
2Chair and Department of Pharmaceutical Botany, Medical University of Lublin, Lublin, Poland
3I Department of Medical Radiology, Medical University of Lublin, Lublin, Poland
4Chair of Internal Medicine and Department of Internal Medicine in Nursing, Medical University of Lublin, Lublin, Poland
Correspondence should be addressed to Anna Grzywa-Celi´nska; [email protected] Received 2 July 2020; Revised 11 November 2020; Accepted 30 December 2020; Published 5 January 2021
Academic Editor: Andrew S. Day
Copyright © 2021 Adam Krusi´nski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Although there are undeniable advantages of treatment of the inflammatory bowel diseases, Crohn’s disease, and ulcerative colitis, with biological agents, the increased susceptibility to tuberculosis should not be ignored. Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis complexwhich includesM. tuberculosis,M. bovis, andM. africanum. Primary tu- berculosis is uncommon in the setting of inflammatory bowel disease: reactivation of latent tuberculosis is of greater concern.
Consequently, latent infection should be excluded in patients who qualify for immunosuppressive treatments. Apart from the review of the literature, this article also presents three cases of different patterns of tuberculosis that occurred during treatment with infliximab, adalimumab, or vedolizumab. The first case reports a case of tuberculosis presenting as right middle lobe pneumonia. The second case featured miliary tuberculosis of the lungs with involvement of the mediastinal lymph nodes, liver, and spleen. The third patient developed a tuberculoma of the right parietal lobe and tuberculous meningitis. It is important to reiterate that every patient qualifying for a biologic agent should undergo testing to accurately identify latent tuberculosis, as well as precise monitoring for the possible development of one of the various forms or patterns of tuberculosis during treatment.
1. Introduction
It is well known that treatment with biological agents for various medical conditions for many patients was revolu- tionary and provided a real chance for positive shift in the course and prognosis of the underlying disease. Biotherapies have become applicable not only in the treatment of in- flammatory bowel diseases (IBD), Crohn’s disease (CD), and ulcerative colitis (UC) but also in the treatment of such conditions as rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) [1] and in therapy of dermatological diseases such as plaque psoriasis [2] and hidradenitis suppurativa (HS) [3]. These biotherapies have also been evaluated in pulmonary diseases such as asthma,
but, despite promising results from preclinical studies, they have proved to be ineffective [4].
In spite of the unquestionable benefits of these bio- therapies, particularly in difficult-to-treat cases of IBD, it is important to not overlook the fact that, in some cases, bi- ological treatments may lead to serious adverse reactions.
One example is the reactivation of latent infection with
Mycobacterium tuberculosisor new-onset tuberculosis (TB).
Although both CD and UC share features of uncon- trolled and relapsing inflammation, they can differ in terms of clinical features, etiology, and treatment. In 5% to 15% of cases (more often among children), it is not possible to differentiate based on the endoscopic or histological ex- amination; in such situations, the term
inflammatory bowelHindawi
International Journal of Inflammation Volume 2021, Article ID 6284987, 8 pages https://doi.org/10.1155/2021/6284987
Research Article
Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients
Gysllene M. C. Brito ,
1Andrea M. M. Fontenele ,
1,2Erika Cristina R. L. Carneiro ,
1Iara Antonia L. Nogueira ,
1Tamires B. Cavalcante ,
2Andr´e A. M. Vale ,
2Sally Cristina M. Monteiro ,
2and Natalino Salgado Filho
21University Hospital of the Federal University of Maranhão, São Lu´ıs 65020-070, Brazil
2Federal University of Maranhão, CEP: 65080-805, São Lu´ıs, Brazil
Correspondence should be addressed to Gysllene M. C. Brito; [email protected]
Received 1 November 2020; Revised 8 June 2021; Accepted 17 June 2021; Published 23 June 2021
Academic Editor: B. L. Slomiany
Copyright © 2021 Gysllene M. C. Brito et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background. The Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR) are inflammatory biomarkers for several diseases, such as cancer and cardiovascular morbidities; however, there are currently few studies on kidney diseases. We aimed to evaluate nondialysis patients and determine the association of NLR and PLR with inflammation in these patients.Methods.
A prospective cross-sectional study was conducted with 85 patients at different stages of chronic kidney disease (CKD), treated at the Kidney Disease Prevention Center of the University Hospital of the Federal University of Maranhão. This study included adult nondialysis patients diagnosed with CKD. The participants’ blood samples were collected for a high-sensitivity C-reactive protein (hs- CRP) test and blood count. They were divided into two groups according to the presence or absence of inflammation based on the hs- CRP value (<0.5 mg/dL). NLR and PLR were calculated based on the absolute number of neutrophils, lymphocytes, and platelets and were compared between them and with hs-CRP. Statistical analysis was performed using the Stata software, with the Shapiro–Wilk, Mann–Whitney, Spearman’s Correlation, and receiver operating characteristic curve tests. This study was approved by the local ethics committee.Results. The participants were categorized into two groups: with inflammation (n�64) and without inflammation (n�21). The mean age was 61.43±14.63 y. The NLR and PLR values were significantly different between the groups with and without inflammation (p�0.045andp�0.004, respectively). However, only PLR showed a significant positive correlation with hs-CRP (p�0.015). The best cutoff point for NLR to detect inflammation was 1.98, with 76.19% sensitivity and 48.44% specificity. For PLR, it was 116.07, with 85.71% sensitivity and 51.56% specificity. There was no significant difference between the area under the NLR and PLR curve (0.71 vs. 0.64;p�0.186) for this population.Conclusions. This study showed that PLR was positively correlated with hs- CRP in nondialysis CKD patients and can be used to identify inflammation in this population.
1. Introduction
Chronic kidney disease (CKD) is characterized by pro- gressive and irreversible loss of renal function. It is a major health issue worldwide, which leads to end-stage renal failure (ESRD) [1]. A systematic review and meta-analysis of observational studies revealed that CKD has an estimated global prevalence between 11 and 13%, and in Brazil, this prevalence, by population criteria, is between 3 and 6 millions of people [2, 3].
CKD has high morbidity and is associated with increased cardiovascular mortality, with 5 to 10 million annual deaths worldwide, followed by infections [1, 3, 4]. Inflammatory processes play a key role in chronic kidney disease and are considered a well-established risk factor for this pathology [5–8].
The chronic systemic inflammation in the CKD, sometimes referred to as low-grade chronic inflammation, is characterized by 2-3-fold increase of acute-phase protein and inflammatory mediators, slow developing, persistent, and of multifactorial origin [6, 8].
Hindawi
International Journal of Inflammation Volume 2021, Article ID 6678960, 7 pages https://doi.org/10.1155/2021/6678960
