Table S1: Risk Prediction Model of Post-Transplant In-hospital Mortality Using the MDRD Equation for Estimated GFR
Variable Coefficient Odds Ratio (95% CI)
P Value
Age at Transplant
≥65 yrs. 0.5308 1.70 (1.3, 2.3) <0.001
Diagnosis (Ref: Dilated/Valvular CM)
Ischemic CM/Other
Hypertrophic/Restrictive CM Congenital Heart Disease
0.3034 0.8479 1.5250
1.35 (1.1, 1.8) 2.34 (1.4, 3.9) 4.60 (2.6, 8.3)
0.02 0.001
<0.001 Mechanical Support (Ref: None)
ECMO TAH/BIVAD LVAD
1.5281 1.2688 0.6967
4.61 (2.0, 10.9) 3.56 (2.3, 5.4) 2.01 (1.5, 2.6)
<0.001
<0.001
<0.001
Ventilator 1.2047 3.34 (2.1, 5.3) <0.001
GFR (Ref: ≥ 90 ml/min/1.73 m2) 60-89
30-59 <30 Dialysis
0.4163 0.7734 1.2033 1.5563
1.52 (1.0, 2.3) 2.17 (1.4, 3.2) 3.33 (1.8, 6.1) 4.74 (2.6, 8.8)
0.05
<0.001
<0.001
<0.001 Total Serum Bilirubin (Ref: < 1
mg/dl) 1.0-2.5 >2.5
0.2412 1.0146
1.27 (1.0, 1.7) 2.76 (1.9, 4.0)
0.07
<0.001 Donor Age (Ref: < 40 yrs.)
40-54 ≥55
0.3946 0.8202
1.48 (1.1, 1.9) 2.27 (1.4, 3.8)
0.003 0.002 Ischemic Time ≥4.5 hrs. 0.2285 1.26 (1.0, 1.7) 0.10
yr (year), CM (Cardiomyopathy), ECMO (Extra-corporeal Membrane Oxygenation), BIVAD (Bi-Ventricular Assist Device), LVAD (Left Ventricular Assist Device), GFR (Glomerular Filtration Rate)
Table S2: Reclassification of Heart Transplant Recipients Based on Estimated Mortality-Risk by the CKD-EPI Equation
Mortality Risk by GFR Estimation Using CKD-EPI Equation (%)
% Risk <5 5-9.99 10-14.99 ≥ 15 Total
Mortality Risk by <5 4665 105 0 0 4770
GFR Estimation 5-9.99 125 1135 35 0 1295
Using MDRD 10-14.99 0 47 248 8 303
Equation (%) ≥15 0 0 21 175 196
Total 4790 1287 304 183 6564
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration), GFR (Glomerular Filtration Rate), MDRD (Modification of Diet in Renal disease)
Figure S1: Predicted versus observed post-transplant in-hospital mortality for the reference model using the MDRD equation for the estimated GFR. The dotted line is the line of identity and the individual points represent deciles of risk.
R2 = 98.4%
0 2 4 6 8 10 12 14 16
Observed Mortality Rate (%)
0 2 4 6 8 10 12 14 16
Expected Mortality Rate (%)
Figure S2: Odds ratios associated with progressive renal dysfunction in risk-models using the MDRD and CKD-EPI equations for estimating GFR. GFR was not estimated in patients on dialysis.