Mesenchymal Stem Cell Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
Maneesh Dave, M.B.B.S., M.P.H. 1, Kathan Mehta, M.B.B.S., M.P.H.2, Jay Luther, MD3, Anushka Baruah, M.B.B.S4, Allan B Dietz PhD 5, William A. Faubion, Jr., M.D.6
1Division of Gastroenterology & Liver Disease, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA; 2Division of Internal Medicine, University of Pittsburgh Medical Centre Shadyside Hospital, Pennsylvania; 3 Division of Gastroenterology & Hepatology, Massachusetts General Hospital, Boston, Massachusetts, USA; 4Division of Internal Medicine, John Stroger Hospital of Cook County, Chicago, Illinois, USA; 5 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA; 6 Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Word count:
Abstract: 122;
Manuscript including the abstract, figure and table legends: 5903 words.
Correspondence:
Maneesh Dave, Division of Gastroenterology & Liver Disease, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH-44106, USA. Tel: 216-844-1995; Fax:
216-844-7371; E-mail: [email protected]
William A Faubion, M.D., Division of Gastroenterology and Hepatology, Guggenheim 10, 200 1st St. SW, Rochester, MN 55905, USA. Tel: 507-284-2468; Fax: 507-255-6318; E- mail: [email protected]
Supplementary table 1: Shows the search strategy used to identify potential studies.
No. Search terms
(PubMed) Search Details (PubMed)
Number of records retrieved
1 Stem Cell AND
Inflammatory Bowel Disease
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] ) AND ((inflammatory bowel disease) OR inflammatory bowel disease[MeSH Terms])
411
2 Stem Cell AND
Ulcerative colitis
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] ) AND ((Ulcerative colitis) OR Ulcerative colitis[MeSH Terms])
114
3 Stem Cell AND
Crohn’s
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] ) AND ((Crohn’s disease) OR Crohn’s
disease[MeSH Terms] OR (Crohns disease) OR (Crohns) OR ((Crohn’s) OR Crohn’s[MeSH Terms]))
260
4 Stem Cell AND
Ileocolitis
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] ) AND ((Ileocolitis) OR Ileocolitis[MeSH Terms])
141
5 Stem Cell AND
Ileitis
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] ) AND ((Ileitis) OR Ileitis[MeSH Terms])
9
6 Stem Cell AND
Colitis
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] ) AND ((Colitis) OR Colitis[MeSH Terms])
344
7 Stem Cell AND
Enteritis
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] ) AND ((Enteritis) OR Enteritis[MeSH Terms])
78
8 Stem Cell AND
Perianal
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] )
AND (Perianal) 40
9 Stem Cell AND Fistula
((Stem Cell) OR stem cell[MeSH Terms] OR (Stem Cells) OR stem cells[MeSH Terms] )
AND ((Fistula) OR Fistula[MeSH Terms]) 78
Embase searches Results
1 exp enteritis/ 153975
2 fistula/ or exp digestive system fistula/ 37254
3
(enteritis or "inflammatory enteropath*" or ((inflam* or ulcer*) adj3 (intestin* or bowel* or colon or colonic)) or appendicitis or
gastroenteritis or colitis or duodenitis or ileitis or typhlitis or
diverticulitis or enterocolitis or pancolitis or proctitis or proctocolitis or megacolon or colorectitis or crohn or crohns or ileocolitis or ileitis or pouchitis or perianal* or fistul*).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword]
269775
4 or/1-3 270253
5 exp Stem Cells/ 183239
6 exp stem cell/ 183239
7 exp stem cell transplantation/ 82339
8
("stem cell*" or "progenitor cell*" or "colony forming unit*" or "mother cell*" or myoblast or myoblasts or "side population cell*" or (embryonic adj2 cell*) or "precursor cell*" or "embryoid body" or "embryoid bodies" or hemangioblast or hemangioblasts or "megakaryocyte erythroid progenitor*").mp. [mp=title, abstract, subject headings,
heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword]
338705
9 or/5-8 338705
10 4 and 9 3427
11 remove duplicates from 10 3353
