The sensitivity analysis for the association between HAdV-36 infection and obesity

Supplemental Figure 1. Forest plots of the studies comparing the association between HAdV-36 infection and obesity by meta-analysis with the random effects model. The pooled OR and 95%CI were calculated. OR, odds ratio; CI, confidence interval. A, population subsets; B, published year; C, study method; D, geographical area; E, detection method; F, sample size.

Supplemental Figure 2. The sensitivity analysis for the association between HAdV-36 infection and obesity.

Supplemental Figure 3. The publication bias plot for the association between HAdV- 36 infection and obesity. A, Egger’s test; B, Begg’s test.

Supplemental Figure 4. Forest plots of the studies comparing the BMI levels in the study subjects with/without HAdV-36 infection by meta-analysis with the random effects model. The SMD and 95%CI were calculated. SMD, standardized mean difference; CI, confidence interval. A, population subsets; B, published year; C, study method; D, geographical area; E, detection method; F, sample size.

Supplemental Figure 5. The sensitivity analysis for the BMI levels in the study subjects with/without HAdV-36 infection.

Supplemental Figure 6. The publication bias plot for the association the BMI levels in the study subjects with/without HAdV-36 infection. . A, Egger’s test; B, Begg’s test.

Supplemental Table 1. The meta-regression analysis on the heterogeneity for the association between HAdV-36 and obesity

Variables Coefficient 95%CI SE t P

Published year 1.080 -3.526 5.686 2.067 0.52 0.613 Geographical area 0.072 -3.810 3.955 1.742 0.04 0.968 Study method 0.910 -3.102 4.923 1.801 0.51 0.624 Detection method 2.251 -2.442 6.944 2.106 1.07 0.310 Population subset -1.519 -5.789 2.750 1.916 -0.79 0.446 Sample size -4.313 -9.740 1.115 2.436 -1.77 0.107 CI, confidence interval; SE, standard error.

Supplemental Table 2. The meta-regression analysis on the heterogeneity for the BMI level between HAdV-36 positive and negative groups

Variables Coefficient 95%CI SE t P

Published year 0.067 -0.787 0.920 0.388 0.17 0.867

Geographical area -0.383 -1.175 0.409 0.360 -1.06 0.310

Study method -0.185 -0.926 0.555 0.337 -0.55 0.593

Detection method 0.263 -0.734 1.260 0.453 0.58 0.573

Population subset -0.845 -1.784 0.094 0.427 -1.98 0.073

Sample size -0.064 -1.178 1.049 0.506 -0.13 0.901

CI, confidence interval; SE, standard error.