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Table S1. Sociodemographic characters of participants Mean ±S. D Median Minimum Maximum Age (years) 24,48 7,16 21,00 17,00 44,00 Weight (kg) 64,86 11,71 62,50 49,00 95,00 Anesthesia time (minutes) 103,80 34,97 102,50 40,00 220,00 Operation time (minutes) 92,70 33,17 90,00 30,00 190,00

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Table S1. Sociodemographic characters of participants

Mean ±S. D Median Minimum Maximum

Age (years) 24,48 7,16 21,00 17,00 44,00

Weight (kg) 64,86 11,71 62,50 49,00 95,00

Anesthesia time (minutes) 103,80 34,97 102,50 40,00 220,00 Operation time (minutes) 92,70 33,17 90,00 30,00 190,00

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Table S2. Sociodemographic characters of participants according to gender

Gender p*

Male (n= 26) Female (n=24) Mean ±S. D Median Mean ±S. D Median

Age (years) 24,38 7,82 21,00 24,58 6,55 23,00 0,598 Weight (kg) 69,69 12,34 68,50 59,63 8,45 57,50 0,002 Anesthesia time

(minutes) 108,27 40,37 100,00 98,96 28,05 107,50 0,769 Operation time

(minutes)

98,08 37,82 90,00 86,88 26,86 95,00 0,441

*Mann Whitney U Test

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Table S3. Heart rate (bpm) according to the stage of anesthesia and osteotomy Mean ±S. D Median Minimum Maximum Heart rate, before anesthesia (bpm) 88,78 16,04 86,00 61,00 129,00 Heart rate 10min before osteotomy (bpm) 75,24 11,40 74,50 55,00 114,00 Heart rate during osteotomy (bpm) 78,84 14,00 74,50 61,00 118,00 Heart rate 10min after osteotomy (bpm) 76,32 13,40 74,50 45,00 126,00

p* <0,001

* Repeated Measures (Greenhouse-Geisser)

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Table S4. Systolic and diastolic blood pressure (mmHg) according to the stage of anesthesia and osteotomy

Mean ±S.

D Median Minimum Maximum Systolic blood pressure, before anesthesia

(mmHg) 120,64 14,10 121,50 92,00 155,00

Diastolic blood pressure, before anesthesia

(mmHg) 72,38 11,75 72,00 49,00 98,00

Systolic blood pressure 10min before

osteotomy (mmHg) 91,36 10,18 91,00 70,00 114,00

Diastolic blood pressure 10min before

osteotomy (mmHg) 46,06 8,30 45,00 26,00 63,00

Systolic blood pressure during osteotomy

(mmHg) 95,60 10,86 93,50 79,00 121,00

Diastolic blood pressure during osteotomy

(mmHg) 49,80 11,62 48,00 24,00 82,00

Systolic blood pressure 10min after

osteotomy (mmHg) 92,40 9,54 92,50 72,00 117,00

Diastolic blood pressure 10min after

osteotomy (mmHg) 47,98 9,30 47,00 27,00 69,00

p* for systolic blood pressure <0,001

p* for diastolic blood pressure <0,001

*Repeated Measures (Greenhouse-Geisser)

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Table S5. BIS score according to the stage of anesthesia and ostetomy

Mean ±S. D Median Minimum Maximum BIS before anesthesia 97,06 1,91 98,00 91,00 98,00 BIS 10min before

osteotomy 39,12 9,85 35,50 27,00 70,00

BIS during osteotomy 43,64 9,68 43,00 25,00 74,00

BIS 10min after osteotomy 40,16 10,52 38,00 24,00 68,00

p* <0,001

* Repeated Measures (Greenhouse-Geisser)

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