Statistically significant difference (i.e. P < 0.05) between mild FI-LAB and moderate FI-LAB.

(1)

Supplemental Table 3: Characteristics of elderly patients with suspected infection, stratified by FI-LAB

Characteristic FI-LAB P Value

Mild

(n = 533) Moderate

(n = 829) Severe (n = 148) Age, years, mean

(SD) 75.4 (7.8) 76.6 (7.9) 78.3 (7.4) <0.001^a,b,c

Male, n (%) 299

(56.1) 465 (56.1) 87 (58.8) 0.82 Comorbidities, n (%)

Congestive Heart

Failure 58 (10.8) 113 (13.6) 21 (14.2) 0.28

Arrhythmia 111

(20.8) 193 (23.3) 28 (18.9) 0.36

Hypertension 138

(25.9) 210 (25.3) 32 (21.6) 0.56 Chronic

Obstructive Pulmonary Disease

31 (5.8) 94 (11.3) 20 (13.5) <0.001^a,b

Diabetes Mellitus 189

(35.5) 323 (38.9) 59 (39.9) 0.37 Renal Failure 37 (6.9) 97 (11.7) 17 (11.4) 0.01^a,b Liver Disease 10 (1.9) 41 (4.9) 14 (9.5) <0.001^a,b,c Metastatic Cancer 81 (15.2) 119 (14.4) 26 (17.6) 0.59 Elixhauser

Comorbidity Score, mean (SD)

4.9 (5.9) 6.1 (6.3) 6.9 (6.7) <0.001^a,b

Origin of Admission, n (%) <0.001^a,b,c

Home 358

(67.2) 482 (58.1) 61 (41.2) Long-term Care

Facility 175

(32.8) 347 (41.9) 87 (58.8) ICU Admission

During Daytime Hours

340

(63.8) 561 (67.7) 85 (57.4) 0.04^b,c ICU MODS

Score, mean (SD) 4.1 (2.8) 5.3 (2.9) 6.3 (2.8) <0.001^a,b,c

Suspected Source of Infection, n (%) 0.98

Pulmonary 259

(48.6) 390 (47.0) 71 (48.0) Gastrointestinal 141

(26.5) 230 (27.7) 39 (26.4) Urinary Tract 74 (13.9) 123 (14.8) 23 (15.5) Skin/Soft Tissue

Infection 16 (3.0) 29 (3.5) 5 (3.4)

Central Nervous

System 21 (3.9_ 34 (4.1) 5 (3.4)

Other/Unknown 22 (4.1) 23 (2.8) 5 (3.4) Previous ED

Visits, mean (SD)

0.84 (0.72)

0.95 (0.84) 0.97 (0.73) 0.26 Previous ICU

Admissions,

0.18 (0.69)

0.22 (0.71) 0.19 (0.77) 0.53

(2)

mean (SD) Previous ICU

Days, mean (SD) 1.96

(11.16) 1.56 (6.73) 2.62 (14.81) 0.77

Supplemental Table 3: Characteristics of ICU patients with suspected infection and index visit to ED within 72 hours of ICU admission. One-way analysis of variance was used to compare mean values, and Kruskal-Wallis was used to compare median values between groups. 

²

was used to compare categorical variables between groups. P-values are displayed. Pairwise comparisons were performed using the Student’s t-test

(parametric values) and Mann-Whitney test (non-parametric values).

^a