Stratum 1 Stratum 2 Stratum 3 Non-surgical diagnosis

Stratum 1 Stratum 2 Stratum 3 Non-surgical

diagnosis

 CCI, IVH

 MAS (7)

 Neonatal sepsis (4)

 Neuroblastoma, resp.

insufficiency

 Pneumothorax, bilat.

 PPHN, Marfan syndrome

 RDS, PPHN (4)

 RDS, pulmonary hemorrhage

 RSV pneumonia

 Subglottic stenosis

 Aspiration pneumonia, T21

 HIV, PjP

 Peritonitis, intraabdominal abcess, ileus

 Pneumococcal pneumonia

 Resp. insufficiency, RI

 Resp. insufficiency, VSD, HOCM, PS

 RSV pneumonia (4)

 Sepsis, meningitis

 Septic shock, RDS

 Aspiration pneumonia 2

 Bronchogenic cyst, respiratory insufficiency

 Burn (2)

 Burn, ARDS

 DCM, CI

 Laryngotracheitis

 Menigococcal sepsis

 Meningitis and cerebritis

 PjP pneumonia

 Pneumonia, CI

 Pneumonia, sepsis 6

 RDS, AML

 RSV pneumonia

 SCID, CMV-infection

 Somnolence

 Tuberculosis, PH Surgical

diagnosis

 CDH (7)

 Meconium ileus

 Oesophageal atresia

 VACTERL

 Intraoral abscess

 medulloblastoma

 SDH, batterd child

 Vocal cord synechia

 CCI, SDH

 Cleft palate

 Francesetti Syndrom, cleft palate, airway obstruction

 Gastrojejunectomy, fundoplicatio

 Intussusception, colonic perforation, sepsis

 M. Hirschsprung, peritonitis

 Opticus-glioma, craniotomy

 Subglottic stenosis Cardiosurgical

diagnosis

 AS, ASD, endocardial fibroelastosis (2)

 AS, CoA

 Aortic valve dysplasia, VSD, AVB III°, PM- implantation

 ALCAPA

 ASD

 AV dissosociation, Glenn-take

 AS, PS

 ASD, T21, RDS, CI

 AVSD, ISTA (2)

 CoA, VSD, ASD, TI

 Complex cardiac defect

 DILV, RVOC, VSD

 DORV, CoA,

 DORV, VSD, ASD

 DORV, VSD, ASD, PS

 HLHS (35) (1 + NEC; 1 + RI)

 IAA, VSD (3)

 Interrupted aortic arch, VSD, ASD

 ISTA, CLD, CI

 ISTA, VACTERL

 ISTA, VSD, ASD (3)

 PA

 SV, TGA, VSD, CoA (2)

 TA, TGA, CoA

 TAC, VSD, ASD

 Taussig-Bing complex

 TAVPR

 TGA (11) (1 + MAS)

 TGA, CoA, VSD

 TGA, PA

 TGA, PA, TAPVR

 VSD (2)

 VSD, ASD, obstruction of pulmonary veins

 VSD, ASD, PS

 VSD, ISTA

 AS, endocardial fibroelastosis

 AS, MS

 ASD (2)

 AV-Channel, aspiration, RDS

 AVSD 2 (+T21)

 BWGS, CI

 DILV, VSD, ASD, TGA

 DORV, VSD

 HLHS, TGA, VSD

 IAA

 ISTA, PH

 Shone complex

 TAC, IAA

 TAC, VSD (7)

 TGA (2)

 TOF

 VSD (2)

 VSD, ASD, PH (2)

 VSD, ASD, T21, PH

 VSD, ISTA

down

 AVSD, T21

 AVSD, TOF

 DORV (3) (1 + CI)

 DORV, PA, (Fontan-OP)

 HLHS

 TA

 TA, PS, VSD, resp.

insufficiency

 TAPVR

 TOF (4)

 VSD

 VSD, JET

Supplemental Digital Content 1, Table 1: Diagnosis according to age strata (in brackets = number of patients): ALCAPA: Anomalous left coronary artery from the pulmonary artery; AML: acute myeloic leukemia; ARDS: acquired respiratory distress syndrome; AS: aortic stenosis; ASD: atrial septum defect; AVSD:

atrioventricular septum defect; BWGS: Bland-White-Garland-Syndrome; CCI: craniocerebral injury; CDH: congenital diaphragmatic hernia; CI: cardiac

insufficiency; CLD: chronic lung disease; CoA: coartatio aortae; CMV: cytomegalovirus; DCM: dilatative cardiomyopathy; DILV: double inlet left ventricle; DORV:

double outlet right ventricle; HOCM: hypertrophic obstructive cardiomyopathy; HIV: human immunodeficiency virus; IAA: interrupted aortic arch; ISTA: stenosis of the aortic isthmus; IVH: intraventricular hemorrhage; JET: junctional ectopic tachycardia; MAS: meconium aspiration syndrome; MS: mitral valve stenosis;

NEC: necrotizing enterocolitis; PA: pulmonary atresia; PH: pulmonary hypertension; PjP: pneumocystis jirovecii pneumonia; PS: pulmonary stenosis; RDS:

respiratory distress syndrome; RI: renal insufficiency; RSV: respiratory synthytial virus; SCID: severe combined immunodeficiency syndrome; SDH: subdural hematoma; SV: single ventricle; TA: tricuspid atresia; TAC: Common arterial trunk; TA: tricuspid atresia; TAPVR: total anomalous pulmonary venous return; TOF:

tetralogy of Fallot; T21: trisomy 21; VSD: ventricular septum defect.