Supplement figure 1: Density plots
20 40 60 80 100 120 140
0.00 0.01 0.02 0.03 0.04 0.05
A: Mean vs Office
Heart Rate
Mean Office
20 40 60 80 100 120 140
0.00 0.01 0.02 0.03 0.04 0.05
B: Day vs Night
Heart Rate
Day Night p<0.0001
p<0.0001
Supplement figure 2: Bland-Altman plots
Supplement figure 3: Scatter plots
Suppl. Figure 4: Cox Regression
All−cause death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<0.0001 ; quadratic trend p=0.4877
A: Difference
−40 −20 0 20 40
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0
Cardiovascular death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<0.0001 ; quadratic trend p=0.4877
−40 −20 0 20 40
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0
Non−Cardiovascular death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<0.0001 ; quadratic trend p=0.4877
−40 −20 0 20 40
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0
All−cause death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<0.0001 ; quadratic trend p=0.1578
B: Morning Mean
30 40 50 60 70 80 90 100 0.0
0.5 1.0 1.5 2.0 2.5
Cardiovascular death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<0.0001 ; quadratic trend p=0.1578
30 40 50 60 70 80 90 100 0.0
0.5 1.0 1.5 2.0 2.5
Non−Cardiovascular death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<0.0001 ; quadratic trend p=0.1578
30 40 50 60 70 80 90 100 0.0
0.5 1.0 1.5 2.0 2.5
All−cause death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p=0.7506 ; quadratic trend p=0.5160
C: Morning Surge
−40 −20 0 20 40 60
0.0 0.5 1.0 1.5 2.0
Cardiovascular death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p=0.7506 ; quadratic trend p=0.5160
−40 −20 0 20 40 60
0.0 0.5 1.0 1.5 2.0
Non−Cardiovascular death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p=0.7506 ; quadratic trend p=0.5160
−40 −20 0 20 40 60
0.0 0.5 1.0 1.5 2.0
All−cause death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<.0001 ; quadratic trend p=0.3400
D: Night Peak
30 40 50 60 70 80 90 100 0.0
0.5 1.0 1.5 2.0
Cardiovascular death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<.0001 ; quadratic trend p=0.3400
30 40 50 60 70 80 90 100 0.0
0.5 1.0 1.5 2.0
Non−Cardiovascular death
Beats per minute (bpm)
Hazard ratio (HR)
linear trend p<.0001 ; quadratic trend p=0.3400
30 40 50 60 70 80 90 100 0.0
0.5
1.0
1.5
2.0
Supplement figure 5: Event rates per 1000 years
<60 ≥
0 10 20
HR groups (bpm)
<60 ≥
0 1 2 3 4 6
HR groups (bpm)
<60 ≥
0 2 4 6 8 10 12 14
HR groups (bpm)
Office Mean Day Night
Events / 1,000 pt. years Events / 1,000 pt. years Events / 1,000 pt. years
