1
The impact of six years of the National Colorectal Cancer Screening Program on colorectal cancer incidence and five year survival
Bojan Tepeš1, Dominika Novak Mlakar2, Milan Stefanovič3, Borut Štabuc4, Snježana Frkovič Grazio4, Jožica Maučec Zakotnik3
Figure 2. Invitation proces of the National Colorectal cancer screening - flow diagram
Table 7. Cancer distribution in colon in three screening rounds (ICD 10)
First round Second round Third round
Location Number Percent Number Percent Number Percent
C180 (cecum) 41 4.8 26 5.5 20 4.9
C182 (ascendent) 54 6.3 29 6.2 33 8.1
C183 (hepatic flexure ) 20 2.3 16 3.4 18 4.4
2
C184 (transverse) 18 2.1 21 4.5 12 3
C185 (splenic flexure) 28 3.2 14 3.0 12 3
C186 (descendent ) 40 4.6 10 2.1 11 2.7
C187 (sigmoid) 351 40.7 160 34.1 118 29.1
C19 (recto sigmoid ) 88 10.3 33 7.0 30 7.4
C20 (rectum) 222 25.7 160 34.2 151 37.3
Total 862 100.0 469 100.0 405 100
Table 8. Prevalence rate for cancer and precancerous lesions ‒ first round of screening
* significant difference Legend:
Prevalence ratio for cancer and 95
% CI
p value Prevalence ratio for advanced adenoma and 95
% CI
p value Prevalence ratio for adenoma and 95 % CI
p value
sex
men 1.00 1.00 1.00
women 0.86 [0.74– 0.99] 0.031* 0.69 [0.65 – 0.74] < 0.0001* 0.86 [0.77 – 0.95] 0.002*
Age groups (years)
50 - 54 1.00 1.00 1.00
55 - 59 1.35 [1.08 – 1.69] 0.008* 1.16 [1.07 – 1.26] < 0.0001* 0.97 [0.84 – 1.11] 0.615 60 - 64 1.43 [1.15 – 1.76] 0.001* 1.19 [1.10 – 1.29] < 0.0001* 0.96 [0.84 – 1.10] 0.580 65 + 2.40 [1.82 – 2.76] < 0.0001* 1.20 [1.10 – 1.31] < 0.0001* 0.95 [0.82 – 1.09] 0.438
Family history 1
yes 1.33 [0.89 – 1.96] 0.158 1.15 [0.97 – 1.36] 0.118 0.59 [0.39 – 0.89] 0.012*
no 1.00 1.00 1.00
Family history 2
yes 1.11 [0.83 – 1.48] 0.497 1.05 [0.93 – 1.19] 0.395 0.89 [0.71 – 1.12] 0.324
no 1.00 1.00 1.00
Acetylsalicylic acid use
yes 0.66 [0.51 – 0.86] 0.002* 0.82 [0.74 – 0.91] < 0.0001* 1.10 [0.94 – 1.29] 0.226
ne 1.00 1.00 1.00
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Family history 1 ‒ first grade relative with colorectal cancer < 60 years of age
Family history 2 ‒ first grade relative with colorectal cancer > 60 years of age or >=2 second grade relatives with colorectal cancer
Acetylsalicylic acid – regular intake of the drug
Table 9. Prevalence ratio for cancer and precancerous lesions ‒ second round of screening
*
significant difference Legend:Family history 1 ‒ first grade relative with colorectal cancer < 60 years of age
Family history 2 ‒ first grade relative with colorectal cancer > 60 years of age or >=2 second grade relatives with colorectal cancer
Prevalence ratio for cancer and 95%
CI
p value Prevalence ratio for advanced adenoma and 95% CI
p value Prevalence ratio for adenoma and 95% CI
p value
SEX
men 1.00 1.00 1.00
women 0.86 [0.71– 1.04] 0.114 0.65 [0.61 – 0.70] < 0.0001* 0.84 [0.77 – 0.91] < 0.0001*
Age groups (years)
50- 54 1.00 1.00 1.00
55 - 59
1.34 [0.99 – 1.82] 0.061 1.06 [0.97 – 1.16] 0.180 1.08 [1.04 – 1.32] 0.008*
60 - 64
1.71 [1.31 – 2.25] < 0.0001* 1.15 [1.06 – 1.25] 0.001* 1.10 [0.97 – 1.22] 0.059 65 + 2.25 [1.69 – 3.01] < 0.0001* 1.18 [1.07 – 1.29] 0.001* 1.17 [0.97 – 1.21] 0.178
Family history 1
yes 0.88 [0.47 – 1.67] 0.704 1.08 [0.89 – 1.32] 0.425 1.28 [1.02 – 1.61] 0.035*
no 1.00 1.00 1.00
Family history 2
yes 1.46 [1.03 – 2.07] 0.035* 1.03 [0.90 – 1.18] 0.651 1.11 [0.95 – 1.23] 0.205
no 1.00 1.00 1.00
Acetylsalicylic acid use
yes 0.88 [0.65 – 1.20] 0.423 0.76 [0.68 – 0.85] < 0.0001* 1.25 [1.11 – 1.40] < 0.0001*
no 1.00 1.00 1.00
4
Acetylsalicylic acid – regular intake of the drugTable 10. Prevalence ratio for cancer and precancerous lesions ‒ third round of screening
Prevalence ratio for cancer and 95%
CI
p value Prevalence ratio for advanced adenoma and 95% CI
p value Prevalence ratio for adenoma and 95% CI
p value
Sex
men 1.00 1.00 1.00
women 0.79 [0.64– 0.97] 0.024* 0.66 [0.61 – 0.70] < 0.0001* 0.76 [0.71 – 0.81] < 0.0001*
Age groups ( years )
50- 54 1.00 1.00 1.00
55 - 59 1.40 [0.81 – 1.61] 0.464 1.03 [0.94 – 1.13] 0.528 1.14 [1.03 – 1.25] 0.012*
60 - 64 1.74 [1.31 – 2.31] < 0.0001* 1.14 [1.05 – 1.24] 0.001* 1.17 [1.07 – 1.28] < 0.0001*
65 + 2.17 [1.59 – 2.96] < 0.0001* 1.11 [1.00 – 1.22] 0.043* 1.24 [1.12 – 1.37] < 0.0001*
Family history 1
yes 1.32 [0.73 – 2.43] 0.358 1.16 [0.95 – 1.42] 0.151 0.94 [0.75 – 1.18] 0.596
no 1.00 1.00 1.00
Family history 2
yes 0.99 [0.63 – 1.54] 0.948 1.16 [1.02 – 1.32] 0.029* 0.95 [0.81 – 1.10] 0.454
no 1.00 1.00 1.00
Acetylsalicylic acid
yes 0.94 [0.68 – 1.29] 0.695 0.83 [0.75 – 0.93] 0.001* 1.04 [0.94 – 1.16] 0.441
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* significant difference Legend:
Family history 1 ‒ first grade relative with colorectal cancer < 60 years of age
Family history 2 ‒ first grade relative with colorectal cancer > 60 years of age or >=2 second grade relatives with colorectal cancer
Acetylsalicylic acid – regular intake of the drug
no 1.00 1.00 1.00