Supplemental Digital Content
Supplemental Table 1: Similar as Table 3, but with specific agreements on the different components of the PELOD-2. Categories represents the number of points that are possible for each organ.
Study
Overall agreement
[%]
Specific agreement per point categories
[%]
Patients number Cohen’s kappa (95% CI) 1st 2nd 3rd 4th 1st 2nd 3rd 4th
Glasgow Coma Score
2 96 98 95 73 276 44 22 0.84 (0.72-0.95)
3 77 87 14 0 274 28 12 0.06 (-0.02-0.14)
2+3 87 92 64 47 550 72 34 0.52 (0.39-0.64)
Pupillary reaction
2 100 100 342 – a
3 100 100 314 – a
2+3 100 100 656 – a
Lactate
2 98 99 88 100 308 32 2 0.88 (0.76-1)
3 96 98 86 89 263 42 9 0.88 (0.79-0.98)
2+3 97 98 86 91 571 74 11 0.88 (0.81-0.95)
Mean arterial pressure
2 84 91 87 77 42 97 156 70 19 0.77 (0.69-0.85)
3 73 82 77 69 33 83 140 61 30 0.59 (0.49-0.7)
2+3 78 87 82 73 37 180 296 131 49 0.68 (0.62-0.75)
Creatinine
2 88 90 86 198 144 0.76 (0.67-0.86)
3 94 93 95 131 183 0.88 (0.81-0.96)
2+3 91 91 91 329 327 0.82 (0.76-0.88)
Invasive ventilation
2 94 95 91 223 119 0.86 (0.78-0.94)
3 93 82 96 61 253 0.78 (0.65-0.9)
2+3 93 92 94 284 372 0.86 (0.81-0.92)
PaO2 : FiO2
2 99 100 0 341 1 0 b
3 90 95 0 299 15 -0.02 (-0.05-0.01)
2+3 95 98 0 640 16 -0.02 (-0.03-0)
PCO2
2 92 95 75 100 285 53 4 0.75 (0.61-0.88)
3 87 91 75 0 230 83 1 0.67 (0.55-0.79)
2+3 90 94 75 80 515 136 5 0.71 (0.62-0.8)
Leukocytes
2 99 99 50 338 4 0.5 (-0.11-1.1)
3 97 98 55 303 11 0.53 (0.17-0.89)
2+3 98 99 53 641 15 0.52 (0.22-0.83)
Platelets
2 92 97 80 0 0 289 45 5 3 0.75 (0.64-0.86)
3 74 78 75 50 164 114 36 0.53 (0.42-0.65)
2+3 84 90 77 44 0 453 159 41 3 0.64 (0.56-0.72)
a Complete agreement with a null variance
b Null variance in one group
Supplemental Fig. 1: Plotted confusion matrix of the aPELOD-2 and mPELOD-2
2 5 4 0 0
2 5 2 3 0
1 7 1 8
1 5 0 2
2 7 1 4 9
3 1 7 0
7 4
3 2 8
0 0
0
1 3 1 1 2
1 0 1 7 5
2 0 4 0 0 0
3 1 6 1 0 0
1 4 6 9 3
0 0 0 0
2 8 1 0 0
9 3 2 0
0 1 5
3 1 2 1 3
3 0
7 8 0 0 0
1 6 1 2 2 0 0
3 2 1 4 8 0
5 1 5 1 1 9
2 4 1 2 0
3 1 5 1 0
0 1 2
L e u k o c y t e s P la t e le t s
C r e a t i n in e I n v a s i v e v e n t il a t i o n P a O 2 - F i O 2 r a t io P C O 2
G C S P u p il la r y r e a c t io n L a c t a t e m ia Mean arterial pressure
0 2 0 1 2 3
0 2 0 3 0 2 0 1 3
0 1 4 0 5 0 1 4 0 2 3 6
0 2 3 6
0 1 3 0
1 4
0 2 0
5
0 3
0 1 2 3 0
1 4
0 2
0 2
m P E L O D - 2
aPELOD-2
0 1 0 0 2 0 0 3 0 0 F r e q u e n c i e s a P E L O D - 2 v s m P E L O D - 2 c o n f u s i o n m a t r i x
Supplemental Table 2: Missing, normal and abnormal values for aPELOD-2 and mPELOD-2 (study 3)
Missing Values Normal Values Abnormal Values aPELOD2 mPELOD2 aPELOD2 mPELOD2 aPELOD2 mPELOD2 Glasgow Coma Score 29 (18.5%) 129 (82.2%) 62 (39.5%) 0 (0%) 66 (42%) 28 (17.8%) Pupillary reaction 47 (29.9%) 75 (47.8%) 109 (69.4%) 0 (0%) 1 (0.6%) 82 (52.2%) Lactate 4 (2.5%) 22 (14%) 117 (74.5%) 0 (0%) 36 (22.9%) 135 (86%) Mean arterial pressure 0 (0%) 5 (3.2%) 11 (7%) 0 (0%) 146 (93%) 152 (96.8%) Creatinine 0 (0%) 6 (3.8%) 56 (35.7%) 0 (0%) 101 (64.3%) 151 (96.2%) Invasive ventilation 16 (10.2%) 0 (0%) 6 (3.8%) 35 (22.3%) 135 (86%) 122 (77.7%) PaO2 : FiO2 22 (14%) 13 (8.3%) 133 (84.7%) 0 (0%) 2 (1.3%) 144 (91.7%) PCO2 0 (0%) 0 (0%) 96 (61.1%) 10 (6.4%) 61 (38.9%) 147 (93.6%) Leukocytes 2 (1.3%) 8 (5.1%) 146 (93%) 0 (0%) 9 (5.7%) 149 (94.9%) Platelets 2 (1.3%) 8 (5.1%) 56 (35.7%) 0 (0%) 99 (63.1%) 149 (94.9%)
