Supplement
Table S1: Subjects’ characteristics by average real variability (ARV) of systolic blood pressure
P value Quintile 5
(n=1777) Quintile 4
(n=1952) Quintile3
(n=1608) Quintile 2
(n=2148) Quintile 1
(n=1913) All study
participants
<0.0001 26.5 (9.6)
15.1 (1.6) 10.8 (0.8)
8.6 (1.0) 3.4 (1.5)
12.4 (9.0) Average Real variability (ARV)
<0.0001 50.8 (7.1)
49.8 (6.9) 48.9 (6.7)
48.3 (6.3) 48.1 (6.4)
49.1 (6.8) Age (years)
<0.0001 26.2 (3.5)
25.7 (3.2) 25.6 (3.2)
.2) 3 25.4 ( 25.3 (3.3)
25.7 (3.3) Body mass Index (kg/m2)
<0.0001 144 (26)
136 (21) 133 (17)
131 (17) 131(16)
135 (20) Systolic blood pressure (mmHg)
<0.0001 88 (13)
85 (11) 83(10)
82 (10) 82 (9)
84 (11) Diastolic blood pressure (mmHg)
<0.0001 212 (41)
211 (40) 208 (39)
208 (40) 206 (39)
209 (40) Cholesterol (mg/dL)
0.35 67.9 69.6
67.6 69.9
66.0 Ever smoked (%) 68.2
0.001 6.2
4.7 4.3
3.5 3.9
Diabetes (%) 4.5
0.0001 9.8
8.6 8.6
7.6 7.0
Coronary Heart Disease (%) 8.3
Table S2: Mortality by average real variability (ARV) of systolic blood pressure
Stroke mortality CHD mortality
All-cause mortality
Rate per 10000 person-years Mortality rate (%)
Rate per 10000 person-years Mortality rate (%)
Rate per 10000 person-years Mortality rate (%)
quintile
10.4 2.2
34.4 7.3
121.9 25.8
1
10.4 2.2
36.3 7.6
127.2 26.6
2
16.5 3.4
47.1 9.8
150.8 31.3
3
20.1 4.1
57.2 11.7
168.1 34.3
4
30.2 5.9
80.5 15.6
232.9 45.1
5
Table S3: All-cause mortality by average real variability (ARV) of systolic blood pressure (SBP) in subjects with SBP increase above and below the average.
Mortality rate (%)
Subjects with BP increase below the average (n = 4932)
Subjects with BP increase above the average (n = 4466)
All subjects (n = 9398) Systolic BP variability
26.0 25.8 25.3
Quintile 1
25.4 26.6 28.0
Quintile 2
29.6 31.3 33.0
Quintile 3
32.2 34.3 36.1
Quintile 4
44.2 45.1 45.8
Quintile 5
Table S4: Hazard ratio for mortality according to average real variability (ARV) of systolic blood pressure.
Stroke mortality CHD mortality
All-cause mortality
95% CI HR
95% CI HR
95% CI HR
Model 1
0.66-1.52 1.00
0.84-1.31 1.05
0.92-1.17 1.04
Quintile 2
1.00-2.23 1.49
1.04-1.64 1.30
1.04-1.35 1.17
Quintile 3
1.14-2.49 1.65
1.19-1.91 1.47
1.08-1.37 1.22
Quintile 4
1.64-3.37 2.33
1.61-2.43 1.98
1.44-1.81 1.62
Quintile 5 Model 2
0.66-1.51 1.00
0.83-1.31 1.04
0.92-1.17 1.03
Quintile 2
0.96-2.15 1.44
1.01-1.59 1.27
1.02-1.30 1.15
Quintile 3
0.97-2.06 1.42
1.07-1.64 1.33
1.00-1.27 1.13
Quintile 4
1.14-2.39 1.65
1.26-1.92 1.55
1.21-1.52 1.35
Quintile 5 Model 3
0.63-1.45 0.95
0.80-1.27 1.01
0.89-1.13 1.01
Quintile 2
0.96-2.15 1.44
0.99-1.57 1.24
1.01-1.29 1.14
Quintile 3
0.97-2.07 1.42
1.06-1.62 1.31
0.99-1.26 1.12
Quintile 4
1.10-2.32 1.60
1.20-1.83 1.48
1.16-1.47 1.31
Quintile 5
CHD =Coronary heart disease, HR = Hazard Ratio, CI = Confidence interval Model 1: Age adjusted
Model 2: Adjusted for age and initial systolic blood pressure
Model 3: Adjusted for age, initial systolic blood pressure, smoking, body mass index, diabetes mellitus and coronary heart disease.
Table S5: Hazard ratio for mortality according to systolic blood pressure variability, when subjects with diabetes mellitus and coronary heart disease at baseline were excluded from the analysis.
Stroke mortality CHD mortality
All-cause mortality
95% CI HR
95% CI HR
95% CI HR
Model 1
0.46-1.21 0.75
0.84-1.47 1.11
0.91-1.20 1.05
Quintile 2
0.57-1.41 0.89
1.01-1.74 1.33
0.97-1.29 1.12
Quintile 3
0.82-1.88 1.24
1.24-2.08 1.60
1.09-1.43 1.25
Quintile 4
1.44-3.11 2.12
1.63-2.68 2.09
1.45-1.88 1.65
Quintile 5 Model 2
0.47-1.21 0.75
0.84-1.47 1.11
0.91-1.20 1.04
Quintile 2
0.52-1.30 0.82
0.97-1.66 1.26
0.94-1.24 1.08
Quintile 3
0.74-1.72 1.13
1.16-1.94 1.50
1.04-1.36 1.19
Quintile 4
1.02-1.25 1.51
1.28-2.15 1.66
1.23-1.59 1.40
Quintile 5 Model 3
0.46-1.19 0.74
0.81-1.42 1.07
0.88-1.17 1.02
Quintile 2
0.51-1.27 0.81
0.93-1.60 1.22
0.92-1.21 1.05
Quintile 3
0.73-1.68 1.11
1.12-1.88 1.45
1.02-1.33 1.16
Quintile 4
0.99-2.18 1.47
1.22-2.04 1.57
1.19-1.55 1.36
Quintile 5
CHD =Coronary heart disease, HR = Hazard Ratio, CI = Confidence interval Model 1: Age adjusted
Model 2: Adjusted for age and initial systolic blood pressure
Model 3: Adjusted for age, initial systolic blood pressure, smoking, and body mass index.
