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SUPPLEMENTAL DATA TABLES
Association between acute kidney injury during invasive mechanical ventilation and intensive care unit outcomes and respiratory system mechanics Sneha V. Vemuri, M.D.
,2,4, Mark L. Rolfsen, M.D.
,4, Alexandra V. Sykes, M.D.
,4, Puja G.
Takiar, M.D.
,4, Austin J. Leonard, B.A.
,4, Atul Malhotra, M.D.
,2,4, Roger G. Spragg
2,4,*Etienne Macedo, M.D., Ph.D.
,3,4, *Mark L. Hepokoski, M.D.
,1,2,4*These authors contributed equally as senior authors
1. VA San Diego Healthcare System, San Diego, CA
2. Division of Pulmonary and Critical Care and Sleep Medicine, University of California San Diego, San Diego, CA
3. Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA
4. Department of Medicine, School of Medicine, University of California, San Diego
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TABLE OF CONTENTS
Survival Analysis, Supplemental Table 1………..PAGE 3
Kidney Outcomes, Supplemental Table 2………..PAGE 4
3 Supplemental Table 1: Survival analysis
Supplemental Table 1: Survival analysis. Abbreviations: AKI, Acute Kidney Injury; IMV,
Invasive Mechanical Ventilation; Ref, Reference Group; nrSOFA: non-renal Sequential Organ Failure Assessment; ICU, Intensive Care Unit; CKD, Chronic Kidney Disease; ACD, Acute Coronary Dysfunction; CHF, Congestive Heart Failure; DM, Diabetes Mellitus; HTN,
Hypertension; CVA, Cerebral Vascular Accident; a, significant difference (p-value <0.01) when compared with ‘No AKI before/ during IMV’; b, p-values from overall Likelihood ratio test; c, p- values from Wald test of variable in equation; d, Model 1: ICU mortality ~ age + gender + nrSOFA score+ ICU location + comorbidities (chronic kidney disease, lung disease, acute coronary dysfunction, congestive heart failure, diabetes mellitus, hypertension, and cerebral vascular accident); e, Model 2 : ICU mortality in ICU location subgroup~ age + gender + nrSOFA score + comorbidities (chronic kidney disease, lung disease, acute coronary dysfunction, congestive heart failure, diabetes mellitus, hypertension, and cerebral vascular accident).
Characteristics
No AKI before/
during IMV (N=2475)
AKI before &
during IMV (N=258)
AKI during IMV
(N=1751) P-value Unadjusted hazard ratio Ref 1.69 [1.26, 2.28] a 1.59 [1.28,1.97] a <0.001 b Adjusted hazard ratio
Age (per year) Ref 1.74[1.29,2.35] a 1.66[1.34,2.05] a <0.001 c Sex (vs. Male) Ref 1.69[1.25,2.28] a 1.59[1.28,1.96] a 0.069 c nrSOFA (per point) Ref 2.03[1.50,2.75] a 1.44[1.16,1.79] a <0.001 c ICU Location Ref 1.49[1.10,2.02] a 1.56[1.25,1.93] a <0.001 c
CKD Ref 1.83[1.27,2.63] a 1.70[1.32,2.19] a 0.47 c
Lung disease Ref 1.81[1.26,2.61] a 1.69[1.31,2.18] a 0.24 c
ACD Ref 1.83[1.28,2.63] a 1.69[1.31,2.18] a 0.38 c
CHF Ref 1.85[1.29,2.67] a 1.68[1.30,2.17] a 0.018c
DM Ref 1.87[1.30,2.70] a 1.70[1.32,2.19] a 0.088 c
HTN Ref 1.81[1.26,2.60] a 1.68[1.30,2.16] a 0.062 c
CVA Ref 1.84[1.28,2.64] a 1.70[1.32,2.20] a 0.305 c
Model 1 d Ref 1.77[1.22,2.56] a 1.55[1.20,2.01] a <0.001b Model 2 e
Surgery Ref 1.78 [0.79,4.00] 1.44[0.90,2.30] 0.001 b
Medical Ref 2.99 [1.76,5.06] a 2.26 [1.46,3.49] a <0.001 b
Cardiac Ref 1.19 [0.31,4.54] 1.67 [0.65,4.31] 0.074 b
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Supplemental Table 2: Kidney outcomes
Outcome AKI, No IMV N=1675
No AKI before/
during IMV N=2475
AKI before &
during IMV N=258
AKI during IMV N=1751 AKI stage
I 1016 (61%) - 59 (23%) a 754 (43%) a, c
II 396 (24%) - 74 (29%) 596 (34 %) a
III 263 (16 %) - 125 (48%) a 401 (23%) a, c
Total days with AKI /
Median [25-75] 3 [2-5] - 11 [7-19] a 7 [4-13] a, c
Time to AKI after
MV/ Median [25,75] - - -2 [-4, -1] 1[1,3]c
Patients Dialyzed
CRRT, N (%) 51 (3) 22 (0.9) 61 (23.6) a, b 286 (16.3) a, b, c
IHD, N (%) 59 (3.5) 24 (1.0) 5 (1.9) 38 (2.2)a
CFB/ Median [25,75]
Non- dialyzed 1099.1 [-1377.7,3983.3]
-4.45 [-2418.5,2358.1]
1528.9 [-2283.7,5462.6] b
1627.8 [-1338.0,5734.3] a, b
Dialyzed 757.3
[-2245.44,3379.5]
968.8 [-1435.2,2959.9]
604.1 [-2989.0,4896.5]
2401.2 [-1576.3,7541.3] a, c
Supplemental Table 2: Kidney outcomes. Abbreviations: AKI, Acute Kidney Injury; CRRT, Continuous Renal Replacement Therapy; IHD, Intermittent Hemodialysis; CFB, Cumulative Fluid Balance. a, significant difference (p-value<0.01) when compared with ‘AKI, No IMV’; b, significant difference (p-value<0.01) when compared with ‘No AKI before/ during IMV’; c, significant difference (p-value<0.01) when compared with ‘AKI before & during IMV.
