Supplemental data

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Supplemental data

Table S1, SDC. Patient demographics and clinical characteristics (at listing) are compared in patients with and without portal vein thrombosis (PVT) at listing. Data are shown as number (percentage) for categorical

variables and median (Interquartile range) for continuous variables.

Patients with and without PVT at listing N=85,295

PVT at listing n=2,819

No PVT at listing n=82,476

p

Age (years) 55 (49 - 61) 54 (48 - 60) <0.001

Male gender 1,881 (66.7%) 53,269 (64.6%) 0.02

Race

Caucasian Black Hispanic Asian

2,049 (72.7%) 138 (4.9%) 477 (16.9%)

107 (2.8%)

59,443 (72.1%) 7,137 (8.7%) 11,259 (13.7%)

3,698 (4.5%)

<0.001

Diabetes Mellitus 880 (31.2%) 19,032 (23.1%) <0.001

Body mass index (Kg/m²) Body mass index>30 Kg/m²

28.3 (24.8 - 32.4) 888 (40.4%)

27.9 (24.5 - 31.9) 14,995 (35.4%)

0.02

<0.001 Liver disease etiology

Hepatitis C infection Alcoholic liver disease Fatty Liver

Cryptogenic

932 (33.1%) 488 (17.3%) 260 (9.2%) 223 (7.9%)

34,367 (41.7%) 14,673 (17.8%) 4,486 (5.4%) 3,823 (4.6%)

<0.001 0.5

<0.001

Liver malignancy 417 (14.8%) 12,865 (15.6%) 0.3

Creatinine (mg/dL) 1 (0.8 - 1.5) 1 (0.8 - 1.3) <0.001

Total Bilirubin (mg/dL) 2.8 (1.6 - 6.5) 2.6 (1.4 - 5.7) <0.001

INR 1.5 (1.3 - 1.9) 1.4 (1.2 - 1.8) <0.001

MELD (model for end-stage liver disease) 17 (13 - 24) 15 (11 - 22) <0.001

Albumin (g/dL) 2.9 (2.4 - 3.4) 3 (2.5 - 3.4) <0.001

Sodium (mEq/L) 136 (133 - 139) 137 (133 - 139) 0.04

Ascites 2,178 (81.6%) 57,486 (74.3%) <0.001

Hepatic encephalopathy 1,762 (66%) 48,320 (62.4%) <0.001

Transjugular intrahepatic portosystemic

shunt 338 (12%) 5,697 (6.9%) <0.001

Waitlist time (days) 100 (18 - 401) 149 (28 - 552) <0.001

Waitlist removal for:

Liver transplant

Death, or too sick to transplant Condition improved

1,660 (58.9%) 765 (27.1%)

109 (3.9%)

46,051 (55.8%) 21,683 (26.3%)

4,112 (5%)

0.001 0.3 0.007 Data on intensive care at the time of listing was missing in >50% of patients and not compared.

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Table S2, SDC. Patient demographics and clinical characteristics (at listing) in patients without portal vein thrombosis (PVT) at listing, comparing those with subsequent PVT and without PVT at liver transplantation (LT). Data are shown as number (percentage) for categorical variables and median (Interquartile range) for continuous variables.

Patients without PVT at listing and available data for PVT at LT N=44,568

Variables at listing PVT at LT n=2,205

No PVT at LT n=42,363

p

Age (years) 55 (49 - 60) 54 (48 - 60) <0.001

Male gender 1,539 (69.8%) 28,529 (67.3%) 0.02

Race

1,610 (72.3%) 146 (6.6%) 326 (14.8%)

103 (4.7%)

30,619 (72.3%) 4,001 (9.4%) 5,310 (12.5%)

1,968 (4.6%)

<0.001

Diabetes Mellitus 639 (30%) 9,513 (22.5%) <0.001

28.6 (25.2 - 32.7) 888 (40.4%)

27.9 (24.5 - 31.9) 14,955 (35.4%)

<0.001

<0.001 Liver disease etiology

Cryptogenic

821 (37.2%) 375 (17%) 200 (9.1%) 367 (16.6%)

17,627 (41.6%) 7,020 (16.6%)

2,448 (5.8%) 4,376 (10.3%)

<0.001 0.6

<0.001

Liver malignancy 395 (18%) 8,424 (19.9%) 0.035

Creatinine (mg/dL) 1 (0.8 - 1.33) 1 (0.8 - 1.3) 0.007

Total Bilirubin (mg/dL) 2.6 (1.6 - 4.9) 2.9 (1.5 - 6.9) <0.001

INR 1.4 (1.2 - 1.78) 1.43 (1.2 - 1.9) 0.2

MELD (model for end-stage liver disease) 16 (12 - 22) 16 (12 - 24) 0.02

Albumin (g/dL) 2.9 (2.5 - 3.3) 2.9 (2.5 - 3.4) 0.1

Sodium (mEq/L) 137 (134 - 139) 136 (133 - 139) 0.6

Ascites 1,699 (79.3%) 30,127 (73.2%) <0.001

Hepatic encephalopathy 1,329 (62%) 25,284 (61.5%) <0.001

shunt 148 (6.7%) 2,709 (6.4%) 0.3

Waitlist time (days) 130 (25 - 431) 71 (15 - 242) <0.001

Data on intensive care at and dialysis at time of listing was missing in >50% of patients and not compared.

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Table S3, SDC. Patient demographics and clinical characteristics (at listing) in patients with portal vein

thrombosis (PVT) at listing, comparing those with PVT and without PVT at liver transplantation (LT). Data are shown as number (percentage) for categorical variables and median (Interquartile range) for continuous

variables.

Patients with PVT at listing and available data for PVT at LT N=1,603

Variables at listing PVT at LT n=969

No PVT at LT n=634

p

Age (years) 56 (50 - 61) 55 (49 - 60) 0.06

Male gender 668 (68.9%) 456 (71.9%) 0.2

Race

701 (72.3%) 49 (5.1%) 169 (17.4%)

32 (3.3%)

470 (74.1%) 42 (6.6%) 87 (13.7%)

24 (3.8%)

0.3

Diabetes Mellitus 309 (32.1%) 179 (28.6%) 0.14

28.3 (24.8 - 32.6) 233 (36.9%)

28.1 (24.5 - 32.1) 379 (39.2%)

0.4 0.4 Liver disease etiology

Cryptogenic

331 (34.2%) 160 (16.5%) 101 (10.4%) 91 (9.4%)

205 (32.3%) 111 (17.5%) 37 (5.8%) 45 (7.1%)

0.4 0.6 0.001

0.11

Liver malignancy 184 (19%) 94 (14.8%) 0.03

Creatinine (mg/dL) 1.1 (0.8 - 1.6) 1.1 (0.8 - 1.6) 0.9

Total Bilirubin (mg/dL) 3.1 (1.8 - 7.5) 3.4 (1.7 - 9.1) 0.4

INR 1.5 (1.3 - 2) 1.5 (1.3 - 2) 0.4

MELD (model for end-stage liver disease) 18 (13 - 25) 18 (13 - 26) 0.6

Albumin (g/dL) 2.9 (2.4 - 3.3) 2.8 (2.4 - 3.4) 0.9

Sodium (mEq/L) 136 (133 - 139) 136 (133 - 139) 0.16

Ascites 802 (84.2%) 497 (81.1%) 0.11

Hepatic encephalopathy 639 (67.1%) 397 (64.8%) 0.3

shunt 87 (9%) 80 (12.6%) 0.02

Data on intensive care at the time of listing was missing in >50% of patients and not compared.