Supplemental Digital Content 1:
Table S1. Correlation of the positive rate of nerve fibers with Clinicopathological Status in 352 Cases of Patients with Breast Cancer (entire cohort)
Clinicopathologic features
No. of
patients
Nerve fiber P-value
+ -
two-sided one-sidedAge(years) 352 130 222
>45 198 73(36.9%) 125(63.1%) 0.978 0.533
≤45 154 57(37.0%) 97(63.0%)
Histological Grade
I 74 10(13.5%) 64(86.5%) <0.001* <0.001**
II 160 58(36.3%) 102(63.8%)
III 118 62(52.5%) 56(47.5%)
Tumor Size (cm)
T1~T2 294 108(36.7%) 186(63.3%) 0.863 0.487
T3~T4 58 22(37.9%) 36(62.1%)
Lymph Node Metastasis
N0 133 44(33.1%) 89(66.9%) 0.007* 0.006**
N1 101 31(30.7%) 70(69.3%)
N2~N3 118 58(49.2%) 60(50.8%)
Distant organ metastasis/ Recurrence
Negative 280 94(33.6%) 186(66.4%) 0.010* 0.008**
Positive 72 36(50.0%) 36(50.0%)
Stage
0~ II 227 73(32.2%) 154(67.8%) 0.012* 0.009**
III ~ IV 125 57(45.6%) 68(54.4%)
Molecular Subtyping
Luminal A 91 36(39.6%) 55(60.4%) 0.413 0.481
Luminal B 197 66(33.5%) 131(66.5%)
HER2+ 43 13(30.2%) 30(69.8%)
Triple negative 21 10(47.6%) 11(52.4%)
Abbreviations: Luminal A: ER+ and/or PR +, Her-2 -;
L uminal B: ER+ and/or PR +, Her-2 +;
H ER2+: ER- and PR-, Her-2 +;
Triple negative: ER-, PR-, Her-2 -
* : p<0.05 by one-sided test, statistically difference.
*
*: p<0.05 by two-sided test, statistically difference.
Supplemental Table S2. Correlation of the positive rate of nerve fibers in different locations with Clinicopathological Status in 352 Cases of Patients with Breast Cancer Clinicopathol
ogic features
No. of patients
center P-value Invasive front
P-value
+ +
Age(years) 352 42 89
>45 198 26 0.276 48 0.552
≤45 154 16 41
Histological Grade
I 120 3 0.004 8 <0.001*
II 160 16 37
III 87 23 44
Tumor Size (cm)
T1~T2 294 19 0.346 59 0.624
T3~T4 58 23 30
Lymph Node Metastasis
N0 133 9 0.094 25 0.04*
N1 101 15 26
N2~N3 118 18 38
Distant organ metastasis/ Recurrence
Negative 280 29 0.509 55 0.025*
Positive 72 13 34
Stage
0~ II 227 25 0.8 50 0.074
III ~ IV 125 17 39
Molecular Subtyping
Luminal A 91 11 0.35 30 0.45
Luminal B 197 12 38
HER2+ 43 15 12
Triple negative 21 4 9
Abbreviations: Luminal A: ER+ and/or PR +, Her-2 -;
Luminal B: ER+ and/or PR +, Her-2 +;
H ER2+: ER- and PR-, Her-2 +;
T riple negative: ER-, PR-, Her-2 -.
* : p<0.05, statistically difference.
