SUPPLEMENTAL DIGITAL CONTENT 4
A Systematic Review of Risk Factors for Delirium in the Intensive Care Unit
I.J. Zaal, MD.; J.W. Devlin, PharmD.; L.M. Peelen, PhD.; A.J.C. Slooter, MD., PhD.
SUPPLEMENT DIGITAL CONTENT 4. Summary of study characteristics
Number First Author Year Study Design Patients delirious / Total (%) Type IC DeliriumAssessment Delirium Assessors Outcome Statistical Model Remarks Quality
1 Abelha 2012 Cohort 26/173 (15%) PACU ICDSC * Incidence Logistic RM Postoperative delirium (PACU) ++
2 Agarwal 2010 Cohort 63/82 (77%) Burn ICU CAM-ICU * Transition (daily) Markov Logistic RMc ++
3 Aldemir 2001 Cohort 90/818 (11%) SICU Interview DSM-IV
Research, Psychiatrist
Prevalencea Logistic RM -
4 Angles 2008 Cohort 41/69 (59%) TICU CAM-ICUb Research Prevalencea Logistic RM Patients with ISS >8 ++
5 Colombo 2012 B/A 80/314 (26%) Mixed ICU CAM-ICU Research Prevalencea Cox RM +
6 Dubois 2001 Cohort 40/198 (19%) Mixed ICU DSM-IV ICDSC
Bedside, Psychiatrist
Incidence Logistic RM FU: 5 days ++
7 Girard 2012 Cohort 107/138 (78%) MICU CAM-ICU Research Transition (daily) Markov Logistic RMc ++
8 Guillamondegui 2011 Cohort 55/97 (57%) TICU CAM-ICU * Prevalencea Logistic RM ++
9 Heyman 2007 Cohort 55/196 (28%) PACU/
MICU
DDS Bedside Prevalencea Logistic RM Cox RM
Outcome DDS > 7 -
10 Lin 2008 Cohort 31/143 (22%) MICU CAM-ICU Research Incidence Logistic RM FU: 5 days ++
11 Morandi 2011 Cohort 40/62 (64%) MICU CAM-ICU Research Delirium next day Logistic RM Nested in ABC trial ++
12 Morandi 2012 Cohort */120a MICU CAM-ICU Research Delirium next day Logistic RM Nested in VALID study ++
13 McNicoll 2003 Cohort 83/118 (70%) MICU CAM-ICU Research Prevalencea Logistic RM FU: ICU plus 7 days ++
14 Ouimet 2007 Cohort 243/764 (32%) Mixed ICU ICDSC Bedside Prevalencea Logistic RM ++
15 Pandharipande 2006 Cohort */198a Mixed ICU CAM-ICU Research Transition (daily) Markov Logistic RMc Medical and Coronary ICU ++
16 Pandharipande 2007 RCT 83/106 (81%) Mixed ICU CAM-ICU Research Prevalence Pearson χ2 test +
17 Pandharipande 2008 Cohort 68/97 (70%) SICU/TICU CAM-ICU Research Transition (daily) Markov Logistic RMc ++
18 Pandharipande 2009 Cohort */97a MICU/SICU CAM-ICU Bedside Transition (daily) Markov Logistic RMc nested in MENDS trial ++
19 Pisani 2007 Cohort 214/304 (70%) MICU CAM-ICUb Research Prevalencea Logistic RM FU: 2 days ++
20 Riker 2009 RCT 225/375 (60%) Mixed ICU CAM-ICU Research Prevalence Incidence
Fisher exact test ++
21 Robinson 2009 Cohort 64/144 (44%) SICU CAM-ICUb Research Prevalencea Logistic RM Outcome: No Delirium ++
22 Ruokonen 2009 RCT 15/85 (18%) Mixed ICU CAM-ICU Research Prevalence Pearson χ2 test Fisher exact test
FU: 45 days +
23 Serafim 2012 Cohort 43/465 (9%) SICU CAM Bedside Prevalencea Logistic RM Exclusion patients on ventilation ++
24 Seymour 2012 Cohort */140a MICU CAM-ICU Research Transition (daily) Markov Logistic RMc nested in ABC trial ++
* =unknown, ++=high quality, +=acceptable quality, - = low quality. a no clear measurement of delirium at ICU admission so frequency considered to be the same as prevalence of delirium,
b in combination with Chart review, c with GEE. B/A=Before after intervention study, CAM-ICU=Confusion Assessment Method for the ICU, D=Delirious patients, DDS=Delirium Detection Score, DSM-IV=Diagnostic Statistic Manual version IV, FU=Follow-up, hrs=hours, ICDSC=Intensive Care Delirium Screening Checklist, ICU=Intensive Care Unit, IMCU=Intermediate Care Unit, ISS = Injury Severity Score, MICU=Medical ICU, ND=Non-delirious patients, NEECHAM=Neelon and Champagne Confusion Scale, Nu-DESC=nursing delirium screening scale, OR=Odds Ratio, PACU=Post Anesthesia Care Unit, RASS=Richmond Agitation and Sedation Scale, RCT=randomized controlled trial, RM = Regression Model, SICU=Surgical ICU, TICU=Trauma ICU.
SUPPLEMENT DIGITAL CONTENT 4.(Continued). Summary of study characteristics
Number First Author Year Study Design Patients delirious / Total (%) Type IC Delirium Assessment Delirium Aassessors Outcome Statistical Model Remarks Quality
25 Shehabi 2013 Cohort 114/259 (44%) Mixed ICU CAM-ICU Research Incidence Cox RM FU: 28 days ++
26 Shi 2010 Cohort 73/164 (45%) SICU Nu-DESC Bedside, Research
Prevalencea Logistic RM FU: 7 days +
27 Svenningsen 2013 Cohort 416/640 (65%) Mixed ICU CAM-ICU Research Prevalencea Logistic RM -
28 van Rompaey 2009 Cohort 155/523 (30%) Mixed ICU NEECHAM * Prevalencea Logistic RM +
29 Van Rompaey 2012 RCT */136 Mixed ICU NEECHAM Bedside Incidence Cox RM FU: 4 days +
30 vd Boogaard 2012 Cohort 911/3056 (30%) Mixed ICU CAM-ICU Bedside Incidence Logistic RM ++
31 Veiga 2012 Cohort 128/680 (19%) PACU ICDSC * Incidence Logistic RM ++
32 Yoshitaka 2013 Cohort 13/40 (33%) SICU CAM-ICU 1 Researcher Prevalencea Logistic RM FU: 2 days ++
33 Zaal 2013 B/A 62/130 (48%) Mixed ICU CAM-ICUb Research Prevalencea Logistic RM +
* =unknown, ++=high quality, +=acceptable quality, - = low quality. a no clear measurement of delirium at ICU admission so frequency considered to be the same as prevalence of delirium,
b in combination with Chart review, c with GEE. B/A=Before after intervention study, CAM-ICU=Confusion Assessment Method for the ICU, D=Delirious patients, DDS=Delirium Detection Score, DSM-IV=Diagnostic Statistic Manual version IV, FU=Follow-up, hrs=hours, ICDSC=Intensive Care Delirium Screening Checklist, ICU=Intensive Care Unit, IMCU=Intermediate Care Unit, ISS = Injury Severity Score, MICU=Medical ICU, ND=Non-delirious patients, NEECHAM=Neelon and Champagne Confusion Scale, Nu-DESC=nursing delirium screening scale, OR=Odds Ratio, PACU=Post Anesthesia Care Unit, RASS=Richmond Agitation and Sedation Scale, RCT=randomized controlled trial, RM = Regression Model, SICU=Surgical ICU, TICU=Trauma ICU.