Supplemental Digital Content 4: Associations between biological age, phenotypic frailty, and recent alcohol exposure in zero-inflated regression models among persons living with HIV, New Orleans
Alcohol Use in HIV Study.
Model Component Outcome Predictor Base Extended
(95% CI) P (95% CI) P
Zero TLFB=0g
DI58 (1.558, 7.824) 0.003 (1.960, 8.534) 0.001 PFI (0.055, 1.240) 0.031 (0.142, 1.386) 0.015 PEth=0ng/mL
DI58 (3.592, 10.057) <.001 (3.755, 10.365) <.001 PFI (-0.118, 1.032) 0.118 (-0.059, 1.130) 0.076
Continuous TLFB
DI58 (-2.301, 1.450) 0.657 (-2.317, 1.398) 0.631 PFI (-0.162, 0.489) 0.324 (-0.179, 0.480) 0.370 PEth
DI58 (-3.817, 0.674) 0.174 (-3.651, 0.710) 0.191 PFI (-0.419, 0.287) 0.691 (-0.488, 0.213) 0.459 Beta-coefficient Wald confidence intervals (CI) and p-values representing the linear effect of frailty on
measures of recent alcohol consumption in zero-inflated models are listed above. The base model accounts for demographic, anthropomorphic, HIV variables, and lifetime alcohol exposure (LAE) rank-percentile only. The extended model additionally accounts for the potentially confounding effects of substance use and smoke- tobacco use. Confidence intervals for the zero model component represents the log-odds of no or undetectable recent alcohol use for each unit increase in frailty. Confidence intervals for the continuous model component represent the log-linear increase in recent alcohol use per unit increase in frailty. Bolded values indicate statistically significant terms (p <0.050). Additional abbreviations: phosphatidylethanol (PEth); 30-day alcohol timeline follow-back (TLFB); 58-item deficit index (DI58); phenotypic frailty index (PFI)
0.00 0.25 0.50 0.75 1.00
0.0 0.1 0.2 0.3 0.4
DI58 Pr ob. of Null 30−Da y Alcohol (eff ect scores)
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10 100 1x10
41x10
61x10
80.0 0.1 0.2 0.3 0.4
DI58 30−Da y Alcohol (g) (eff ect scores)
0.00 0.25 0.50 0.75 1.00
Non−Frail Pre−Frail Frail
PFI Pr ob. of Null 30−Da y Alcohol (eff ect scores)
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