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Supplementa l Digital Content
Search terms
Embase, 1176
('organ care system'/de OR 'isolation perfusion'/exp OR 'organ perfusion'/de OR 'heart perfusion'/exp OR 'organ transportation system'/de OR (transmedics OR organ-care- system* OR OCS OR ((organ) NEAR/3 (transport* OR preser*) NEAR/3 (system*)) OR ((perfus*) NEAR/3 (warm* OR hot* OR normoterm* OR normo-term* OR normotherm*
OR normo-therm* OR ex-vivo* OR exvivo* OR ex-situ* OR exsitu* OR machine*))):ab,ti,kw) AND ('heart transplantation'/exp OR 'heart donor'/de OR (('heart'/exp/mj) AND ('transplantation'/exp/mj)) OR (((heart*) NEAR/6 (transplant* OR graft* OR donor*))):ab,ti,kw) NOT ((animal/exp OR animal*:de OR nonhuman/de) NOT ('human'/exp)) AND [ENGLISH]/lim NOT ([Conference Abstract]/lim AND [2018-2021]/py) Medline, 461
(exp "Perfusion"/ OR (transmedics OR organ-care-system* OR OCS OR ((organ) ADJ3 (transport* OR preser*) ADJ3 (system*)) OR ((perfus*) ADJ3 (warm* OR hot* OR normoterm* OR normo-term* OR normotherm* OR normo-therm* OR ex-vivo* OR exvivo* OR ex-situ* OR exsitu* OR machine*))).ab,ti,kf.) AND ("Heart Transplantation"/
OR ((exp "Tissue Donors"/) AND (exp "Heart"/)) OR ((exp *"Transplantation"/) AND (exp
*"Heart"/)) OR (((heart*) ADJ6 (transplant* OR graft* OR donor*))).ab,ti,kf.) NOT (exp animals/ NOT humans/) AND (english).lg.
Web-of-Science, 380
TS=(((transmedics OR organ-care-system* OR OCS OR ((organ) NEAR/2 (transport* OR preser*) NEAR/2 (system*)) OR ((perfus*) NEAR/2 (warm* OR hot* OR normoterm* OR normo-term* OR normotherm* OR normo-therm* OR ex-vivo* OR exvivo* OR ex-situ* OR exsitu* OR machine*)))) AND ((((heart*) NEAR/5 (transplant* OR graft* OR donor*)))) NOT ((animal* OR rat OR rats OR mouse OR mice OR murine OR dog OR dogs OR canine OR cat OR cats OR feline OR rabbit OR cow OR cows OR bovine OR rodent* OR sheep OR ovine OR pig OR swine OR porcine OR veterinar* OR chick* OR zebrafish*
OR baboon* OR nonhuman* OR primate* OR cattle* OR goose OR geese OR duck OR macaque* OR avian* OR bird* OR fish*) NOT (human* OR patient* OR women OR woman OR men OR man))) AND DT=(Article OR Review OR Letter OR Early Access) AND LA=(English)
Cochrane, 65
(transmedics OR organ NEXT care NEXT system* OR OCS OR ((organ) NEAR/3 (transport* OR preser*) NEAR/3 (system*)) OR ((perfus*) NEAR/3 (warm* OR hot* OR normoterm* OR normo NEXT term* OR normotherm* OR normo NEXT therm* OR ex NEXT vivo* OR exvivo* OR ex NEXT situ* OR exsitu* OR machine*)):ab,ti,kw) AND (((heart*) NEAR/6 (transplant* OR graft* OR donor*)):ab,ti,kw)
Google Scholar, 200
Transmedics|"organ care system"|OCS warm|normotermic|"normo termic"|normothermic|"normo thermic"|"ex vivo"|exvivo|"ex situ"|exsitu "heart transplantation"|"donor heart"|"donor hearts" perfusion
3 Supplemental Tables
Author Year Study design
Sample size OCS vs SCS (n)
Marginal donor/
recipient
Comments
OCS-DBD (vs SCS-DBD)
Ardehali et al 2015 RCT 67 vs 63 No
Chan et al 2017 RCT 19 vs 19 No Follow-up study
of Ardehali et al García Sáez
et al
2014 Cohort 26 Yes, donor/
recipient Kaliyev et al 2020 Cohort 25 vs 10 No Koerner et al 2014 Cohort 29 vs 130 No
Pya et al 2021 Cohort 43 No Follow-up study
of Kaliyev et al
Sato et al 2019 RCT 16 vs 18 No Substudy of
Ardehali et al Sponga,
Benedetti et al
2020 Cohort 14 vs 24 Yes, recipient
Sponga, Bonetti et al
2020 Cohort 21 vs 79 Yes, donor
OCS-DCD (vs SCS-DBD)
Chew et al 2019 Cohort 23 vs 106 Yes, DCD Mehta et al 2019 Cohort 3 OCS-DBD / 7
OCS-DCD
Yes, DCD
Messer et al 2020 Cohort 57 vs 79 Yes, DCD Table S1. Overview of included studies.
OCS-DBD: donation after brain death hearts perfused on the Organ Care System;
OCS-DCD: donation after circulatory death hearts perfused on the Organ Care System;
SCS-DBD: donation after brain death hearts preserved with static cold storage.
5 Cohort
studies
Selection Comparability Outcome
First author
Year 1 2 3 4 5 6 7 8 Total
OCS-DBD (vs SCS-DBD)
García Sáez
2014 * * * * * * 6
Kaliyev 2019 * * * * * * 6
Koerner 2014 * * * * * * * 7
Pya 2021 * * * * * * 6
Sponga, Benedetti
2020 * * * * * * * 7
Sponga, Bonetti
2020 * * * * * * * 7
OCS-DCD (vs SCS-DBD)
Chew 2019 * * * * * * * 7
Mehta 2019 * * * * * * * 7
Messer 2020 * * * * * * * 7
Table S2. Outcomes of Newcastle-Ottawa Quality Assessment Scale for cohort studies,
with the cohort being a HF patient needing cardiac transplantation.
OCS-DBD: donation after brain death hearts perfused on the Organ Care System;
OCS-DCD: donation after circulatory death hearts perfused on the Organ Care System;
SCS-DBD: donation after brain death hearts preserved with static cold storage.
Author Year D1 D2 D3 D4 D5 Overall
Ardehali 2015 + + + + + +
Table S3. Outcome of Cochrane Risk of Bias Tool. Assessment was done with 30-day
survival as outcome and OCS and SCS as the groups being compared.
+ Low risk. D: domain.
OCS: Organ Care System; SCS: static cold storage.
7
Author ICU stay (days)
OCS SCS p-value
DBD
Ardehali 6.1 (range 4.5-8.8) 5.7 (range: 4.0 to 8.2)
0.24
Chana NR NR NR
García Sáez 6 (range: 2-149) NR NR
Kaliyev 19 (range: 5-42) NR NR
Koerner NR NR NR
Mehta 10 (range: 7-21) NR NR
Pyaa NR NR NR
Satoa NR NR NR
Sponga, Benedetti 8 (range: 3-34) 11 (range: 2-70) 0.67 Sponga, Bonetti 5 (range: 2-20) 6 (range: 2-83) 0.06 DCD
Chew 7 (range:2-22) 7 (range: 1-65) >0.05
Mehta 14 (range: 3-69) NR NR
Messer 8 (IQR: 4-15) 6 (IQR: 4-10) NR
Table S4. Overview of duration of ICU stay for the individual studies.
aOverlapping populations.
DBD: donation after brain death; DCD: donation after circulatory death; ICU: intensive care unit; OCS: Organ Care System; NR: not reported; SCS: static cold storage.
Author Hospital stay (days)
OCS SCS p-value
DBD
Ardehali NR NR NR
Chana NR NR NR
García Sáez 39 ± 29 NR NR
Kaliyev NR NR NR
Koerner 26 (range: 20-108) 28 (range: 19-143) 0.80
Mehta 30 (range: 26-33) NR NR
Pyaa NR NR NR
Satoa NR NR NR
Sponga, Benedetti 61 (range: 21-110) 40 (range: 14-263) 0.14 Sponga, Bonetti 32 (range: 19-102) 33 (range: 14-279) 0.77 DCD
Chew 24 (range: 7-60) 27 (range: 3-292) >0.05
Mehta 31 (range: 23-69) NR NR
Messer 25 (IQR: 20-33) 25 (IQR: 19-33) NR
Table S5. Overview of duration of hospital stay for the individual studies.
aOverlapping populations.
DBD: donation after brain death; DCD: donation after circulatory death; OCS: Organ Care System; NR: not reported; SCS: static cold storage.
