Supplemental Digital Content 3. Number of Serious Medically Attended Events among MenACWY-CRM Recipients 2 to 10 Years of Age by HCUP class.

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Supplemental Digital Content 3. Number of Serious Medically Attended Events among MenACWY-CRM Recipients 2 to 10 Years of Age by HCUP class.

Event

Potential cases identified

(a)

Excluded cases based on

pre- existing condition^¥

(b)

Total # Incident

Serious Medically

Attended Events (c=a-b)

Days to event

HCUP class Median

(min-max) IR (95%CI)*

1.3 Viral infection 3 2 1 256 4.8 (0.7 - 34.1)

1.4 Other infections; including parasitic 1 0 1 211 3.4 (0.5 - 24.4)

2 Neoplasms 1 0 1 86 3.4 (0.5 - 24.4)

2.14 Neoplasms of unspecified nature or uncertain behavior 1 0 1 86 3.3 (0.5 - 23.8)

3 Endocrine; nutritional; and metabolic diseases and immunity disorders 4 3 1 138 4.9 (0.7 - 34.6)

3.8 Fluid and electrolyte disorders 2 1 1 138 3.5 (0.5 - 25.0)

6 Diseases of the nervous system and sense organs 7 6 1 120 10.4 (1.5 - 74.2)

6.5 Headache; including migraine 4 1 3 196 (120-345) 10.7 (3.5 - 33.2)

7 Diseases of the circulatory system 4 2 2 264.5 (186-343) 7.4 (1.9 - 29.7)

7.2 Diseases of the heart 1 0 1 343 3.6 (0.5 - 25.6)

7.3 Cerebrovascular disease 1 0 1 186 3.4 (0.5 - 24.1)

7.4 Diseases of arteries; arterioles; and capillaries 2 0 2 163.5 (141-186) 6.9 (1.7 - 27.5)

8 Diseases of the respiratory system 15 14 1 345 10.5 (1.5 - 74.9)

8.1 Respiratory infections 12 11 1 345 8.2 (1.1 - 57.9)

8.2 Chronic obstructive pulmonary disease and bronchiectasis 1 0 1 12 3.4 (0.5 - 24.3)

8.8 Other lower respiratory disease 5 2 3 50 (12-186) 13.6 (4.4 - 42.2)

9 Diseases of the digestive system 10 8 2 246 (186-306) 10.3 (2.6 - 41.1)

9.4 Upper gastrointestinal disorders 2 1 1 186 3.5 (0.5 - 24.9)

9.5 Abdominal hernia 1 0 1 6 3.4 (0.5 - 24.2)

9.7 Biliary tract disease 4 1 3 141 (96-211) 10.1 (3.3 - 31.5)

9.12 Other gastrointestinal disorders 7 6 1 306 4.1 (0.6 - 29.1)

10 Diseases of the genitourinary system 3 1 2 111.5 (37-186) 7.9 (2.0 - 31.7)

10.1 Diseases of the urinary system 2 1 1 186 3.8 (0.5 - 26.8)

10.2 Diseases of male genital organs 1 0 1 37 3.4 (0.5 - 24.3)

12 Diseases of the skin and subcutaneous tissue 1 0 1 120 4.5 (0.6 - 32.1)

12.4 Other skin disorders 1 0 1 120 3.8 (0.5 - 26.7)

13 Diseases of the musculoskeletal system and connective tissue 3 2 1 289 4.2 (0.6 - 29.6)

13.9 Other bone disease and musculoskeletal deformities 1 0 1 289 3.5 (0.5 - 24.5)

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16 Injury and poisoning 17 10 7 133 (33-343) 41.4 (19.7 - 86.8)

16.2 Fractures 1 0 1 80 3.6 (0.5 - 25.9)

16.4 Intracranial injury 1 0 1 133 3.4 (0.5 - 23.8)

16.6 Open wounds 5 1 4 237.5 (33-359) 14.3 (5.4 - 38.2)

16.8 Superficial injury; contusion 6 2 4 126.5 (74-145) 16.0 (6.0 - 42.7)

16.9 Burns 3 1 2 230 (117-343) 6.8 (1.7 - 27.1)

16.12 Other injuries and conditions due to external causes 4 3 1 133 3.9 (0.5 - 27.6)

17.1 Symptoms; signs; and ill-defined conditions 9 8 1 22 6.1 (0.9 - 43.6)

18 Residual codes; unclassified; all E codes 20 16 4 83 (33-145) 36.1 (13.6 - 96.3)

Number of subjects experiencing single events 3

Number of subjects experiencing multiple events 18

¥ Serious medically attended events were excluded from further analysis if any event in the same HCUP class and/or subclass was present in the subject’s medical history (up to three years prior).

*Cases per 1000 person-years

HCUP class = Healthcare Cost and Utilization Project (HCUP) clinical classifications system; IR = incidence rate; CI = confidence interval