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Supplemental Digital Content 3. Showing the results of further logistic regression analysis was performed on the parameters with statistically significant differences between the enterovirus (EV) and human parechovirus (HPeV)-infected children.

Enterovirus

(EV)

Human parechovirus (HPeV)

p-value Abnormal WCC

(normal: 6.0 - 17.0)

20% (26/127) 56% (18/32) <0.001

above higher limit 6% 0%

below lower limit 14% 56%

Abnormal neutrophils (normal: 1.50 - 8.50)

21% (27/126) 9% (3/32) 0.138

above higher limit 18% 6%

below lower limit 3% 3%

Abnormal lymphocytes (normal: 4.00 - 13.50)

39% (49/126) 91% (29/32) <0.001

above higher limit 0% 0%

below lower limit 39% 91%

Abnormal CSF WCC (normal: 0-20)

50% (64/129) 6% (2/31) <0.001

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