Supplemental Digital Content
Appendix S1. Detailed search strategies Table S1. Overlapping cohorts.
Figure S1. Forest plots indicating a significant effect of patient factors on frailty after KT.
Figure S2. Forest plots indicating a significant effect of frailty on the occurrence of adverse outcomes after KT.
Figure S3. Forest plots showing pooled standardized mean difference for significant outcomes.
Appendix S1. Detailed search strategies.
All searches were performed on 26-05-2020
PubMed
("Kidney transplantation"[Mesh] OR “renal transplant*”[tiab] OR “kidney transplant*”[tiab]) AND ("Frailty"[Mesh] OR frail*[tiab] OR “fragility”[tiab] OR "sarcopenia"[Mesh] OR
“sarcopenia”[tiab] OR “low muscle mass“[tiab] OR “muscle loss“[tiab] OR “unintentional weight loss”[tiab] OR “malnutrition“[tiab] OR “physical activity”[tiab] OR
“exhaustion”[tiab] OR "cognition"[Mesh] OR “cognit*”[tiab] OR “depressi*”[tiab] OR “grip strength”[tiab] OR "gait speed"[tiab] OR “slowness”[tiab] OR “weakness”[tiab])
Embase
('kidney transplantation':ab,ti OR 'renal transplant*':ab,ti OR 'kidney transplant*':ab,ti) AND ('frailty'/exp OR 'sarcopenia':ab,ti OR 'cognition':ab,ti OR 'frail*':ab,ti OR 'fragility':ab,ti OR 'low muscle mass':ab,ti OR 'muscle loss':ab,ti OR 'unintentional weight loss':ab,ti OR
'malnutrition':ab,ti OR 'physical activity':ab,ti OR 'exhaustion':ab,ti OR 'cognit*':ab,ti OR 'depressi*':ab,ti OR 'grip strength':ab,ti OR 'gait speed':ab,ti OR 'slowness':ab,ti OR 'weakness':ab,ti)
Web of Science
TS=(("Kidney transplantation" OR "renal transplant*" OR "kidney transplant*") AND ("Frailty" OR "frail*" OR "fragility" OR "sarcopenia" OR "low muscle mass" OR "muscle loss" OR "unintentional weight loss" OR "malnutrition" OR "physical activity" OR
"exhaustion" OR "cognition" OR "cognit*" OR "depressi*" OR "grip strength" OR "gait speed" OR "slowness" OR "weakness"))
OvidSP
("Kidney transplantation" OR "renal transplant*" OR "kidney transplant*") AND ("Frailty"
OR "frail*" OR "fragility" OR "sarcopenia" OR "low muscle mass" OR "muscle loss" OR
"unintentional weight loss" OR "malnutrition" OR "physical activity" OR "exhaustion" OR
"cognition" OR "cognit*" OR "depressi*" OR "grip strength" OR "gait speed" OR "slowness"
OR "weakness")
Cochrane
#1 MeSH descriptor: [Kidney Transplantation] explode all trees
#2 ''renal transplant*''tiab OR ''kidney transplant*''tiab
#3 ''frail*''ti,ab,kw OR “fragility”ti,ab,kw OR “sarcopenia”ti,ab,kw OR “low muscle mass“ti,ab,kw OR “muscle loss“ti,ab,kw OR “unintentional weight loss”ti,ab,kw OR
“malnutrition“ti,ab,kw OR “physical activity”ti,ab,kw OR “exhaustion”ti,ab,kw OR
“cognit*”ti,ab,kw OR “depressi*”ti,ab,kw OR “grip strength”ti,ab,kw OR "gait speed"ti,ab,kw OR “slowness”ti,ab,kw OR “weakness”ti,ab,kw
#4 MeSH descriptor: [Frailty] explode all trees
#5 MeSH descriptor: [Sarcopenia] explode all trees
#6 MeSH descriptor: [Cognition] explode all trees
#7 (#1 OR #2) AND (#3 OR #4 OR #5 OR #6)
Google scholar
allintitle:("Kidney transplantation" OR “kidney transplant” OR “renal transplant” OR “renal transplantation”) AND ("Frailty" OR “fragility” OR "sarcopenia" OR “low muscle mass“ OR
“muscle loss“ OR “unintentional weight loss” OR “malnutrition“ OR “physical activity” OR
“exhaustion” OR "cognition" OR “depression” OR “grip strength” OR "gait speed" OR
“slowness” OR “weakness” OR “frail” OR “cognitive” OR “depressive”)
Table S1. Overlapping cohorts.
Author Hospital Cohort 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018
Chu 2019 JH 569
Chu 2019 JH + UM 665
Garonzik-Wang
2012
JH 183
Haugen 2018 JH + OPTN 893/125.304a
Haugen 2020 JH + UM
+ MST + SRTR
1763/243.508
Konel JH + UM 773
McAdams-Demar
co 2013
JH 383
McAdams-Demar co 2015
JH + SRTR
537/37.858
McAdams-DeMar co 2015
JH 525
McAdams-Demar co 2015
JH 349
McAdams-DeMar co 2017
JH + SRTR
589/173.868a
McAdams-Demar co 2017
JH 663
McAdams-Demar co 2018
JH 370
UM 73
Nastasi 2018 JH 645
UM 74
a Noted as participants in the novel cohorts/patients from SRTR data
JH = John Hopkins Hospital, SRTR = Scientific Registry of Transplant Recipients, UM = University of Michigan Medical Center in Ann Arbor, OPTN = Organ Procurement and Transplantation Network, MST = Methodist Specialty and Transplant Hospital
Study details Year
Figure S1. Forest plots indicating a significant effect of patient factors on frailty after KT.
Figure S2. Forest plots indicating a significant effect of frailty on the occurrence of adverse outcomes after KT.
Figure S3. Forest plots showing standardized mean difference for significant outcomes.
(A) Age
