SUPPLEMENTAL DIGITAL MATERIAL
Resistance in aerobic Gram-negative bacilli (AGNB)
Except for Klebsiella, Enterobacter, most Enterobacteriaceae were susceptible to
antimicrobials (Supplemental Table 1). Antimicrobial susceptibility was determined by the disk diffusion method or MIC when performed. For the purpose of the study, reduced
susceptibility was considered resistant. For each species, there were no statistically significant differences in the rates of susceptibility to the antimicrobials studied between groups. The distribution of multi-drug resistant AGNB involved in AIs in both groups is shown in Supplemental Table 2.
Time to occurrence for ICU-acquired infection
The cumulative hazard of AIs in both groups is shown in Supplemental Figure 1
(Supplemental Digital Content 2, http://links.lww.com/CCM/A816).
Supplemental Table 1. Antibiotic susceptibility of 150 aerobic Gram-negative isolates tested
Group A Group B
Tic Pip/taz Ctx Caz Cefe Imi Gen Tob Ami Cip Total Tic Pip/taz Ctx Caz Cefe Imi Gen Tob Ami Cip Total
Aerobic Gram-negative bacilli – no susceptible (%)
E. coli 7
(33)
11/15 (73)
17 (81)
17 (81)
11/14 (79)
21 (100)
17 (81)
14/18 (78)
19 (90)
14 (67)
21 8
(62)
11/11 (100)
13 (100)
13 (100)
13 (100)
13 (100)
11 (85)
11 (85)
13 (100)
11 (85)
13
Klebsiella 3/11
(27) 6 (50)
7 (58)
4/10 (40)
12 (100)
10 (83)
8 (67) 11 (92)
6 (50) 12 2 (40) 2 (40) 2 (40) 2 (40) 5
(100) 2 (40)
1 (20)
4 (80) 1 (20)
5
Enterobacter 8 (40)
8 (40) 8 (40)
8 (40)
18/18 (100)
20 (100)
18 (90)
12/14 (86)
20 (100)
15/16 (94)
20 1
(25)
1 (25) 1 (25) 1 (25) 3 (75) 4 (100)
2 (50)
2 (50)
3 (75) 3 (75)
4
Serratia 2
(33)
2 (33) 3 (50)
3 (50)
6 (100) 6 (100)
3 (50)
2 (33) 5 (83) 4 (67) 6 2 (50)
2 (50) 4 (100)
4 (100)
4 (100)
4 (100)
2 (50)
1 (25)
3 (75) 4 (100)
4
Citrobacter 0/2 0/2 0/2 0/2 2/2
(100)
1/2 0/2 0/2 0/2 4 0
Proteus 1
(25)
4 (100) 4 (100)
4 (100)
4 (100) 4 (100)
4 (100)
2/2 (100)
4 (100)
4 (100)
4 0
Morganella 3
(100)
3 (100) 3 (100)
3 (100)
3 (100) 3 (100)
3 (100)
3 (100)
3 (100)
3 (100)
3 0
Pseudomonas aeruginosa
19 (70)
21 (78) 22
(81)
20 (74) 22 (81)
18 (67)
18 (67)
24 (89)
17 (63)
27 4/11
(36) 5/11 (45)
8 (62) 6/11 (55)
8 (62) 8 (62)
8 (62)
11 (85)
8 (62)
13
Acinetobacter 6 (100)
6 (100) 0 0 6
(100) 5 (83)
3 (50) 3 (50) 1 (17) 6 0
Stenotrophomonas maltophilia
0 1 (11) 0 1
(11)
0 6 (67) 4
(44)
1 (11) 3 (33) 8 (89) 9 0
Burkholderia cepacia 0/1 1/1
(100) 1/1 (100)
1/1 (100)
0 0/1 0 0 0 1
Note: Tic, ticarcillin; Pip/taz, piperacillin/tazobactam; Ctx, cefotaxime; Caz, ceftazidime; Cefe, cefepime; Imi, imipenem; Gen, gentamicin; Tob, tobramycin; ami, amikacin; Cip, ciprofloxacin.
