Supplemental Digital Table 1. Generation of diagnostic categories Diagnostic Category CCS Level(s) and any other components
Non-AIDS Defining Infection
CCS Level 1 (Infectious and parasitic diseases) CCS Level 6.1 (Central nervous system infection) CCS Level 6.7.5 (Inflammation; infection of eye) CCS Level 6.8.1 (Otitis media and related conditions) CCS Level 7.2.2.2 (Other peri-;endo-; and myocarditis) CCS Level 8.1 (Respiratory infections)
CCS Level 9.1 (Intestinal infection)
CCS Level 9.6.5 (Anal and rectal conditions) CCS Level 9.6.6 (Peritonitis and intestinal abscess) CCS Level 10.1.4 (Urinary tract infections)
CCS Level 10.2.2 (Inflammatory conditions of male genital organs) CCS Level 10.3.2 (Inflammatory diseases of female pelvic organs) CCS Level 12.1 (Skin and subcutaneous tissue infections)
CCS Level 13.1 (Infective arthritis and osteomyelitis)
CCS Level 16.10.1.2 (Infection and inflammation – internal prosthetic device; implant; and graft)
CCS Level 16.10.2.6 (Postoperative infection) ICD-9’s 785.52, 995.91, and 995.92 (Septic shock) AIDS Defining Illness1
See Supplemental Digital Table 2 Symptom Defined
CCS Level 17 (Symptoms; signs; and ill-defined conditions and factors influencing health status)2
Psychiatric
CCS Level 5 (Mental illness) Oncologic
CCS Level 2 (Neoplasms)2 Pulmonary
CCS Level 8 (Diseases of the respiratory system)2 Endocrine / Metabolic /
Nutritional / Immune
CCS Level 3 (Endocrine; nutritional; and metabolic diseases and immunity disorders)2
Gastrointestinal / Liver
CCS Level 9 (Diseases of the digestive system)2 ICD-9 571.2 (Alcoholic cirrhosis)
Cardiovascular
CCS Level 7 (Diseases of the circulatory system)2 Renal / Genitourinary
CCS Level 10 (Diseases of the genitourinary system)2
ICD-9’s 403.0, 403.1, 403.9 (Hypertensive chronic kidney disease) Hematologic
CCS Level 4 (Diseases of the blood and blood-forming organs) Injury / Poisoning
CCS Level 16 (Injury and poisoning)2 Neurologic
CCS Level 6 (Diseases of the nervous system and sense organs)2 Obstetric / gynecologic
CCS Level 11 (Complications of pregnancy; childbirth; and the puerperium)
Dermatologic
CCS Level 12 (Diseases of the skin and subcutaneous tissue)2 Musculoskeletal
CCS Level 13 (Diseases of the musculoskeletal system and connective tissue)2
Unclassified
CCS Level 18 (Residual codes; unclassified; all E codes) Perinatal
CCS Level 15 (Certain conditions originating in the perinatal period) Congenital
CCS Level 14 (Congenital anomalies)
1 AIDS Defining Illness took highest precedence among categories, so when specific ICD-9 codes fit this category (see Supplementary Digital Table 2), they were classified as such rather than with other categories (i.e. non-AIDS defining infection, oncologic, pulmonary, or endocrine / metabolic / nutritional / immune)
2 Excluding any CCS sub-levels or individual ICD-9 codes assigned to the Non-AIDS Defining Infection or AIDS Defining Illness categories
CCS, Clinical Classification Software; ICD-9, International Classification of Diseases, 9th Revision