Supplemental Material Supplemental Figures Captions
Supplemental Figure 1: Correlation between other DECT techniques and true fat content. DECT monochromatic 140 keV CT numbers had the strongest correlation with true fat content (R2 = 0.98) while the others had R2 values between 0.68 (DECT
monochromatic 40 keV CT numbers) to 0.93 (DECT VUE CT numbers). DECT: dual-energy CT; I: iodine; HU: Hounsfield units.
Supplemental Figure 2: Correlation between SECT techniques and true fat content.
The correlation of SECT 120 kVp CT numbers and SECT variable kVp CT numbers (adjusted to the varying body sizes) with true fat content were 0.92 and 0.88, respectively.
SECT = single-energy CT; I: iodine; HU: Hounsfield units.
Supplemental Figure 3: Non-inferiority assessment of DECT monochromatic 140 keV
CT number compared to MR PDFF. The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and MR (blue lines and points). The lower panels show the difference in AUC between techniques at each difference in fat content. The error bars are 95% confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of -0.1. The
points are marked non-inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points) based on the 95% confidence interval and non-inferiority margin.
DECT: dual-energy CT; MR PDFF: magnetic resonance proton density fat fraction; AUC: area under the curve.
Supplemental Figure 4: Non-inferiority assessment of DECT monochromatic 40 keV
CT number compared to MR PDFF. The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and MR (blue lines and points). The lower panels show the difference in AUC between techniques at each difference in fat content. The error bars are 95% confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of -0.1. The points are marked non-inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points) based on the 95% confidence interval and non-inferiority margin.
DECT: dual-energy CT; MR PDFF: magnetic resonance proton density fat fraction; AUC: area under the curve.
Supplemental Figure 5: Non-inferiority assessment of DECT monochromatic 75 keV
CT number compared to MR PDFF. The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and MR (blue lines and
points). The lower panels show the difference in AUC between techniques at each difference in fat content. The error bars are 95% confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of -0.1. The points are marked non-inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points) based on the 95% confidence interval and non-inferiority margin.
DECT: dual-energy CT; MR PDFF: magnetic resonance proton density fat fraction; AUC: area under the curve.
Supplemental Figure 6: Non-inferiority assessment of DECT VUE CT number compared to MR PDFF. The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and MR (blue lines and points). The lower panels show the difference in AUC between techniques at each difference in fat content. The error bars are 95%
confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of -0.1. The points are marked non- inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points) based on the 95% confidence interval and non-inferiority margin. DECT: dual-energy CT;
MR PDFF: magnetic resonance proton density fat fraction;
AUC: area under the curve.
Supplemental Figure 7: Non-inferiority assessment of SECT 120 kVp CT number
compared to MR PDFF. The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and MR (blue lines and points). The lower panels show the difference in AUC between techniques at each difference in fat content. The error bars are 95%
confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of -0.1. The points are marked non- inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points) based on the 95% confidence interval and non-inferiority margin. DECT: dual-energy CT;
MR PDFF: magnetic resonance proton density fat fraction;
AUC: area under the curve.
Supplemental Figure 8: Non-inferiority assessment of SECT 80 kVp and 140 kVp CT number compared to MR PDFF. The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and MR (blue lines and points). The lower panels show the difference in AUC between techniques at each difference in fat content. The error bars are 95% confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of -0.1. The points are marked non-inferior to MR PDFF (white points),
inferior (black points), or indeterminate (gray points) based on the 95% confidence interval and non-inferiority margin.
DECT: dual-energy CT; MR PDFF: magnetic resonance proton density fat fraction; AUC: area under the curve.
Supplemental Figure 1
Supplemental Figure 1: Correlation between other DECT techniques and true fat content. DECT monochromatic 140 keV CT numbers had the strongest correlation with true fat content (R2 = 0.98) while the others had R2 values between 0.68 (DECT
monochromatic 40 keV CT numbers) to 0.93 (DECT VUE CT numbers). DECT: dual- energy CT; I: iodine; HU: Hounsfield units.
Supplemental Figure 2
Supplemental Figure 2: Correlation between SECT techniques and true fat content.
The correlation of SECT 120 kVp CT numbers and SECT variable kVp CT numbers (adjusted to the varying body sizes) with true fat content were 0.92 and 0.88, respectively. SECT = single-energy CT; I: iodine; HU: Hounsfield units.
Supplemental Figure 3
Supplemental Figure 3: Non-inferiority assessment of DECT monochromatic 140 keV CT number compared to MR PDFF. The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and
points) and MR (blue lines and points). The lower panels show the difference in AUC between techniques at each
difference in fat content. The error bars are 95% confidence intervals. The horizontal dashed lines indicate the non-
inferiority margin of -0.1. The points are marked non-inferior to MR PDFF (white points), inferior (black points), or
indeterminate (gray points) based on the 95% confidence interval and non-inferiority margin. DECT: dual-energy CT; MR
PDFF: magnetic resonance proton density fat fraction; AUC: area under the curve.
Supplemental Figure 4
Supplemental Figure 4: Non-inferiority assessment of DECT monochromatic 40 keV CT number compared to MR PDFF.
The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and
MR (blue lines and points). The lower panels show the difference in AUC between techniques at each difference in fat
content. The error bars are 95% confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of –
0.1. The points are marked non-inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points)
based on the 95% confidence interval and non-inferiority margin. DECT: dual-energy CT; MR PDFF: magnetic resonance
proton density fat fraction; AUC: area under the curve.
Supplemental Figure 5
Supplemental Figure 5: Non-inferiority assessment of DECT monochromatic 75 keV CT number compared to MR PDFF.
The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and
MR (blue lines and points). The lower panels show the difference in AUC between techniques at each difference in fat
content. The error bars are 95% confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of –
0.1. The points are marked non-inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points)
based on the 95% confidence interval and non-inferiority margin. DECT: dual-energy CT; MR PDFF: magnetic resonance
proton density fat fraction; AUC: area under the curve.
Supplemental Figure 6
Supplemental Figure 6: Non-inferiority assessment of DECT VUE CT number compared to MR PDFF. The top panels show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and MR (blue lines
and points). The lower panels show the difference in AUC between techniques at each difference in fat content. The error
bars are 95% confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of -0.1. The points are
marked non-inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points) based on the 95%
confidence interval and non-inferiority margin. DECT: dual-energy CT; MR PDFF: magnetic resonance proton density fat
fraction; AUC: area under the curve.
Supplemental Figure 7
Supplemental Figure 7: Non-inferiority assessment of SECT 120 kVp CT number compared to MR PDFF. The top panels
show the AUC for detecting a difference in fat content over the range for DECT (red lines and points) and MR (blue lines
and points). The lower panels show the difference in AUC between techniques at each difference in fat content. The error
bars are 95% confidence intervals. The horizontal dashed lines indicate the non-inferiority margin of -0.1. The points are
marked non-inferior to MR PDFF (white points), inferior (black points), or indeterminate (gray points) based on the 95%
confidence interval and non-inferiority margin. DECT: dual-energy CT; MR PDFF: magnetic resonance proton density fat
fraction; AUC: area under the curve.
Supplemental Figure 8
Supplemental Figure 8: Non-inferiority assessment of SECT 80 kVp and 140 kVp CT
number compared to MR PDFF. The top panels show the AUC for detecting a difference
in fat content over the range for DECT (red lines and points) and MR (blue lines and
points). The lower panels show the difference in AUC between techniques at each
difference in fat content. The error bars are 95% confidence intervals. The horizontal
dashed lines indicate the non-inferiority margin of -0.1. The points are marked non-
inferior to MR PDFF (white points), inferior (black points), or indeterminate (graypoints)
based on the 95% confidence interval and non-inferiority margin. DECT: dual-energy
CT; MR PDFF: magnetic resonance proton density fat fraction; AUC: area under the
curve.
