Supplemental Digital Content 4. Risk of RSV Disease During November–March by GA, Chronologic Age on November 1, Chronologic Age During November–March, and 2012 AAP Environmental Risk Factors.
A: RSV Outpatient LRI
Rate per 100 Infant-Seasons, %
0 10 20 30 40 50
<3 months of age during November-March
3 to <6 months of age during November-March
6 months of age during November-March
<3 M onths on Nov e mbe r 1 3 to <6 M onths on Nov e mbe r 1
0 10
6 13
9 16
20 25
3
14 15
19
22
9
29
19
2012 AAP Risk Factors wGA
Numbe r of Subje cts Ov e rall Incide nce
(95% CI)
32-34
-
320 5.7 (2.8, 10.1)
32-34 35
+ -
141 377
13.1 (6.3, 24.2)
12.2 (8.0,17.7)
35
+
287 21.7 (15.2, 30.0)
32-34 32-34 35 35
- + - +
141
143 113 110
10.0 (5.2, 17.5)
18.1 (11.0, 27.9)
12.8 (6.6, 22.3)
21.9 (13.3, 33.7)
B: RSV ED Visits
AAP=American Academy of Pediatrics; ED=emergency department; GA=gestational age; LRI=lower respiratory tract illness; RSV=respiratory syncytial virus; wGA=weeks GA. Rates are per 100 infant-seasons. For chronologic age during November–March, subjects contributed events and exposure time only while they were within specific age ranges. Overall incidence rates are for November–March regardless of chronologic age during November–March. The plus (+) and minus (−) symbols represent the presence or absence of 2012 AAP environmental risk factors, respectively. AAP risk factors were associated with increased rates of RSV-related events (P<0.02 for all event types).
Rate per 100 Infant-Seasons, %
0 5 10 15
20 <3 months of age during
November-March
3 to <6 months of age during November-March
6 months of age during November-March
<3 M onths on Nov e mbe r 1 3 to <6 M onths on Nov e mbe r 1
2 5
6 18
7
3
11
4
0 4
9
6
4 9
12
8
2012 AAP Risk Factors wGA
Numbe r of Subje cts Ov e rall Incide nce
(95% CI)
32-34 32-34 35
- + -
141
320 377
4.1 (1.8, 8.1)
11.8 (5.4, 22.3)
4.4 (2.1, 8.1)
35
+
287 6.3 (3.1, 11.3)
32-34 32-34
- +
141 143
2.4 (0.5, 7.1)
6.9 (3.0, 13.6)
35 35
+ -
113 110
7.1 (2.9, 14.7)
9.3 (4.3, 17.7)