Supplemental Table S2. All-cause mortality in never-smokers relative to the stable class, by sex and age group.
Men Women
Pattern NDeath/N HR (95%-CI) for death Pattern NDeath/N HR (95%-CI) for death
< 50 years of age
Stable 81 / 2,950 (ref.) 1.00 Stable 74 / 4,640 (ref.) 1.00
Steady increase 7 / 116 3.57 (1.64 – 7.80) High stable 27 / 808 1.48 (0.94 – 2.33) Decrease – increase 1 / 35 0.97 (0.13 – 6.98) Steady increase 6 / 262 1.44 (0.62 – 3.31) Increase – decrease 2 / 38 0.67 (0.15 – 3.05) Increase – decrease 4 / 88 2.67 (0.97 – 7.32)
50-65 years of age
Stable 272 / 1,595 (ref.) 1.00 Stable 324 / 2,834 (ref.) 1.00
Increase – plateau 8 / 47 1.10 (0.54 – 2.24) High stable 106 / 751 1.15 (0.92 – 1.43) Plateau – decrease 22 / 47 2.79 (1.81 – 4.32) Plateau – decrease 44 / 176 1.91 (1.40 – 2.62) Plateau – increase 5 / 18 1.39 (0.57 – 3.39) Plateau – increase 15 / 117 1.35 (0.80 – 2.26)
> 65 years of age
Stable 188 / 292 (ref.) 1.00 Stable 385 / 703 (ref.) 1.00
Plateau – decrease 13 / 13 2.62 (1.48 – 4.62) Plateau – decrease 69 / 88 1.68 (1.30 – 2.17) Decrease – plateau 3 / 3 8.90 (2.61 – 30.39) High stable 41 / 84 1.28 (0.92 – 1.77)
Supplemental Table S1. All-cause mortality after exclusion of first five years of follow-up relative to the stable class, by
sex and age group.Men Women
Pattern NDeath/N HR (95%-CI) for death Pattern NDeath/N HR (95%-CI) for death
< 50 years of age
Stable 127 / 5,300 (ref.) 1.00 Stable 101 / 6,957 (ref.) 1.00
Steady increase 8 / 261 1.68 (0.82 – 3.46) High stable 38 / 1,163 1.42 (0.97 – 2.08) Decrease – increase 3 / 89 1.37 (0.44 – 4.33) Steady increase 11 / 451 1.57 (0.84 – 2.94) Increase – decrease 5 / 81 1.17 (0.46 – 3.00) Increase – decrease 6 / 152 2.10 (0.91 – 4.85)
50-65 years of age
Stable 437 / 2,637 (ref.) 1.00 Stable 313 / 3,116 (ref.) 1.00
Increase – plateau 15 / 89 0.86 (0.51 – 1.44) High stable 103 / 832 1.17 (0.93 – 1.46) Plateau – decrease 30 / 63 2.90 (2.00 – 4.20) Plateau – decrease 41 / 184 2.07 (1.49 – 2.86) Plateau – increase 10 / 35 1.62 (0.87 – 3.04) Plateau – increase 21 / 146 2.01 (1.29 – 3.14)
> 65 years of age
Stable 227 / 406 (ref.) 1.00 Stable 310 / 640 (ref.) 1.00
Plateau – decrease 11 / 11 2.55 (1.38 – 4.70) Plateau – decrease 46 / 66 1.55 (1.14 – 2.11) Decrease – plateau 2 / 6 0.67 (0.16 – 2.78) High stable 33 / 79 1.22 (0.85 – 1.76)