Supplemental Table 2. Mean (SD) Cardiopulmonary exercise testing data
Patients Controls
Author (year)
Measurement time point VO2 (units) RER VE (L/min)
Blood Lactate (mmol/L)
VO2 (units) RER VE (L/min)
Blood Lactate (mmol/L)
Alkan (2008) n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a
Andrade (2017) Peak 15 (3.6) mL/kg/min 1.1 (0.13) 36 (12) n/a 19 (4.2) mL/kg/min 1.2 (0.09) 43.8 (12.5) n/a
Bardal (2013) Anaerobic threshold
(Blood lactate=4mmol/L) 1 (0.3) L/min 0.99 (0.03) 40 (9.1) NR 1.7 (0.4) L/min 1 (0.02) 46.7 (12) NR Bardal (2015) Anaerobic threshold
(Blood lactate>5mmol/L) 1 (0.28) L/min NR NR NR 1.6 (0.29) L/min NR NR NR
Bazelmans (2001) 3 minutes after starting the test
2.01
(0.74) L/min NR NR NR 2.27 (0.68) L/min NR NR NR
Cook (2005) Average across the test 45 (7)
% peak NR NR n/a 43 (4) % peak NR NR n/a
47 (11)
Cook (2006)
Peak 26 (6)
mL/kg/min 1.2 (0.1) 77 (20)
n/a 30 (8) mL/kg/min 1.2 (0.1) 88 (30) n/a
23 (4) 1.2 (0.1) 68 (15)
Cook (2012) Average across the test 46 (7)
% peak 0.9 (0.06) 23 (7.8)
n/a 44 (4.9) % peak 0.8 (0.05) 24.4 (6.9) n/a 53 (16.9) 0.9 (0.06) 24 (7.6)
Cook (2017) Average across the test 13 (4.3) mL/kg/min 1 (0.2) 3.7 (1.1) 3.7 (1.1)b 16 (3.3) mL/kg/min 0.9 (0.04) 3.3 (1.3) 3.3 (1.3)b
Cook (2003a) Peak 29 (6.7) mL/kg/min 1.3 (0.1) 90 (21) n/a 31 (7.1) mL/kg/min 1.2 (0.1) 113 (28.3) n/a Cook (2003b) Peak 30 (5.8) mL/kg/min 1.1 (0.1) 71 (13) n/a 31 (4.6) mL/kg/min 1.1 (0.1) 69.7 (14.2) n/a
Supplemental Table 2 continued. Mean (SD) Cardiopulmonary exercise testing data
Patients Controls
Author (year) Measurement
time point VO2 (units) RER VE (L/min)
Blood Lactate (mmol/L)
VO2 (units) RER VE (L/min)
Blood Lactate (mmol/L) Fulcher (2000) 8 minutes 24 (3) mL/kg/min NR 70 a 5.4 (2.2) 26 (5) mL/kg/min NR 82.4 a 6.8 (2.1)
Gibson (1993) Peak n/a n/a n/a 7.0 (3.2) n/a n/a n/a 8.6 (2)
Guillamo (2010)
Averaged last 2 minutes of
exercise
9 (2.4) mL/kg/min 0.9 (0.1) 20 (7.3) n/a 8.7 (1.7) mL/kg/min 0.8 (0) 16 (2.6) n/a
Hodges (2018) Peak 25 (8.9) mL/kg/min NR NR n/a 32 (10.9) mL/kg/min NR NR n/a
Hsieh (2010) Peak 19 (3.7) mL/kg/min 1.1 (0.06) NR n/a 21 (3.2) mL/kg/min 1.1 (0.07) NR n/a Javierre (2007) Peak 10 (2.8) mL/min/kg 0.95 (0.16) 26 (9.7) 2.4 (0.9) 18 (4.8) mL/kg/min 1.05 (0.11) 39.8 (8.4) 4.3 (1.56)
Keech (2016) Peak 15 (4.6) mL/kg/min NR 32 (9.5) n/a 18 (4.1) mL/kg/min NR 33.3 (8.5) n/a
Learmouth (2014) n/a n/a n/a n/a n/a n/a n/a n/a n/a
Light (2009) n/a n/a n/a n/a n/a n/a n/a n/a n/a
Light (2012) n/a n/a n/a n/a n/a n/a n/a n/a n/a
Meyer (2013) Peak 31 (7.6) mL/kg/min 1.3 (0.1) NR n/a 30 (9.5) mL/kg/min 1.3 (0.08) NR n/a
Nelson (2019) Peak 27 (9.2) mL/kg/min NR NR n/a 30 (6.1) mL/kg/min NR NR n/a
Paul (2001) n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a
Riley (1990) Peak 32 (5.3) mL/kg/min 1.1 (0.1) NR 4.3 (1.5) 38 (5.1) mL/kg/min 1.2 (0.1) NR 5.4 (1.2)
Supplemental Table 2 continued. Mean (SD) Cardiopulmonary exercise testing data
Patients
Controls
Author (year)
Measurement
time point
VO2
(units)
RER
VE
(L/min)
Blood Lactate
(mmol/L)
VO2
(units)
RER
VE (L/min)
Blood Lactate
(mmol/L)
Robinson (2010)
Lactate
threshold
22 (2.9)
mL/kg/min
1.1 (0.06)
NR
9 (2.4)
25 (5.6)
mL/kg/min
1.1 (0.03)
NR
9.2 (2.3)
Rowbottom (1998)
12 minutes
(6kph)
17 (3.08) mL/kg/min
NR
27 (5.6)
n/a
16 (2.2)
mL/kg/min
NR
27.3 (4.4)
n/a
Shukla (2015)
Peak
29 (9)
mL/kg/min
1.2 (0.1)
NR
n/a
28 (9.6)
mL/kg/min
1.2 (0.11)
NR
n/a
Simms (1994)
Peak
30 (8.1)
mL/kg/min
1 (0.2)
49 (16.9)
n/a
32 (7.2)
mL/kg/min
1.1 (0.4)
54.8 (9.3)
n/a
Sisto (1996)
Peak
28 (5.1)
mL/kg/min
1.1 (0.1)
65 (10.3)
n/a
32 (4.3)
mL/kg/min
1.2 (0.08)
71.9 (13.4)
n/a
Strahler (2013)
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Suarez (2010) Immediately
post‐exercise 17 (5.5) mL/kg/min 1.01 (0.15) n/a 3.1 (1.8) 25.6 (6) mL/kg/min 1.2 (0.11) n/a 6.6 (1.8)
Van Oosterwijck (2017)
Immediately
post‐exercise
17 (4.25) mL/kg/min
0.76 (0.89) 32 (9.67)
n/a
20 (6.8)
mL/kg/min
0.7 (0.08)
31.6 (11.3)
n/a
Verstappen (1995)
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
White (2010)
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
White (2012)
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Yoshiuchi (2007)
Peak
22 (3.3)
mL/kg/min
1.1 (0.08)
NR
n/a
26 (5.7)
mL/kg/min
1.2 (0.13)
NR
n/a
Note. n/a = not applicable because the authors did not report using equipment needed for taking these specific measurements; NR = not reported or unclear; RER = respiratory exchange ratio; VO
2= Oxygen consumption; VE = minute ventilation
a
Standard deviation not reported or unclear
b
Measure recorded at a different time‐point from other variables