Supplemental Table A Patients’ responses to questions regarding their ICU stay – Day 3, 28 and 90
All Patient Protocolized Sedation + Daily
Interruption (PS + DI) Protocolized Sedation (PS) Day 3 Day 28 Day 90 Day 3 Day 28 Day 90 Day 3 Day 28 Day 90
N 155 121 100 83 62 51 72 59 49
1. Remember admission to
hospital
Clearly 63(41) 56(47) 38(38) 31(38) 25(42) 20(39) 32(45) 31(53) 18(37) Hazily 39(26) 18(15) 23(23) 27(33) 12(20) 11(22) 12(17) 6(10) 12(25) Not at all 51(33) 45(38) 39(39) 24(29) 23(38) 20(39) 27(38) 22(37) 19(39) 2. Remember
time before ICU
All of it 34(22) 13(11) 13(13) 18(22) 6(10) 9(18) 16(22) 7(12) 4(8) Some of
it 57(37) 41(35) 36(36) 30(37) 24(40) 18(35) 27(38) 17(29) 18(38) Nothing
at all 63(41) 64(54) 50(51) 34(42) 30(50) 24(47) 29(40) 34(59) 26(54) 3. Remember
being in the ICU
Yes 110(7) 88(74) 64(64) 59(73) 48(79) 36(71) 51(72) 40(69) 28(57) No 42(28) 31(26) 36(36) 22(27) 13(21) 15(29) 20(28) 18(31) 21(43) 4. Remember
all the stay
Yes 19(12) 10(9) 6(6) 11(13) 6(10) 4(8) 8(11) 4(7) 2(4)
No 134(88) 108(92) 94(94) 71(87) 54(90) 47(92) 63(89) 54(93) 47(96) 6. Enough
sleep
Yes 76(51) 75(66) 65(71) 45(55) 39(65) 33(70) 31(46) 36(68) 32(71) No 74(49) 38(34) 27(29) 37(45) 21(35) 14(30) 37(54) 17(32) 13(29)
If no, reason
Pain 15(20) 9(24) 6(22) 9(24) 5(24) 2(14) 6(16) 4(4) 4(31)
Noise 35(47) 19(50) 11(41) 16(43) 8(38) 4(29) 19(51) 11(5) 7(54)
Bright
light 23(31) 15(40) 9(33) 13(35) 7(33) 3(21 10(27) 8(47) 6(46)
Loud
speaking 30(41) 17(45) 9(33) 14(38) 7(33) 3(21) 16(43) 10(9) 6(46)
Bathing 3(4) 1(3) 4(15) 2(5) 0(0) 2(14) 1(3) 1(6) 2(15)
Tests 22(30) 6(16) 9(33) 9(24 3(14) 4(29) 13(35) 3(18) 5(9)
People entering
the room 25(34) 10(26) 10(37) 11(30) 5(24) 4(29) 14(38) 5(29) 6(46) Other 30(41) 23(61) 14(52) 15(41) 12(57) 7(50) 15(41) 11(65) 7(54) 6b. Prefer
more awake
Yes 30(22) 26(24) 20(23) 18(23) 12(20) 9(19) 12(19) 14(2) 11(27)
No 115(79) 89(77) 69(78) 62(78) 48(80) 39(81) 53(82) 41(75) 30(73) 9. remember
transfer from ICU
Clearly 98(65) 65(56) 54(55) 51(63) 37(62) 34(67) 47(68) 28(49) 20(42) Hazily 34(23 ) 39(33) 27(27) 21(26) 19(32) 8(16) 13(19) 20(35) 19(40) Not at all 18(12) 13(11) 18(18) 9(11) 4(7) 9(18) 9(13.) 9(16) 9(19) 10. Panic or
apprehension
Yes 39(26) 26(23) 15(16) 20(26) 12(21) 11(23) 19(27) 14(25) 4(8)
No 109(74) 87(77) 80(84) 58(74) 45(79) 37(77) 51(73) 42(75) 43(92) 11a. Intrusive Yes 26(18) 21(18) 12(12) 14(18) 9(16) 6(12) 12(18) 12(21) 6(13)
Data presented as N (%) unless otherwise indicated.
memories No 118(82) 93(82) 86(88) 63(82 ) 49(85) 44(88) 55(82) 44(79) 42(88)
12. Talked about it with
Family
member 107(69) 96(79) 81(81) 56(68) 50(81) 40(78) 51(71) 46(78) 41(84) Doctor on
the ward 13(8) 17(14) 17(17) 8(10) 8(13) 9(18) 5(7) 9(15) 8(16)
Nurse on
the ward 10(6) 8(7) 7(7) 5(6.0) 5(8) 4(8) 5(7) 3(5) 3(6)
family
doctor 1(0.6) 16(13) 17(17) 1(1) 9(15) 9(18) 0(0) 7(12) 8(16)
No one 34(2) 18(5) 11(11) 18(22) 7(11) 4(8) 16(22) 11(19) 7(14)
Other 8(5) 12(10) 8(8.) 5(6) 7(11) 2(4) 3(4) 5(9) 6(12)
Supplemental Table B. Memories by randomization group on days 3, 28, 90
Day 3 Day 28 Day 90
What do you remember?
Protocolized Sedation + Daily Interruption N = 80
Protocoli zed Sedation N = 64 P
Protocoli zed Sedation + Daily Interrupti on N = 58
Protoco lized Sedatio n
N = 55 P
Protocoliz ed Sedation + Daily Interruptio n
N = 48
Protocoli zed Sedation N = 44 P Factual memories
Any factual memory (≥1
of these 11) 77 (96) 63 (98) 0.63 56 (97) 51 (93) 0.43 46 (96) 41 (93) 0.67 Faces 43 (54) 37 (58) 0.63 32 (55) 23 (42) 0.16 25 (52) 17 (39) 0.20 Family 61 (76) 45 (70) 0.42 48 (83) 39 (71) 0.13 33 (69) 29 (66) 0.77 Alarms 40 (50) 31 (48) 0.85 30 (52) 19 (35) 0.07 25 (52) 16 (36) 0.13 Voices 49 (61) 39 (61) 0.97 35 (60) 26 (47) 0.16 28 (58) 27 (61) 0.77 Lights 39 (49) 25 (39) 0.25 31 (53) 19 (35) 0.04 26 (54) 12 (27) 0.008 Darkness 20 (25) 16 (25) 1.0 19 (33) 7 (13) 0.01 17 (35) 8 (18) 0.06 Clock 18 (23) 12 (19) 0.58 12 (21) 14 (25) 0.55 11 (23) 7 (16) 0.40 Breathing
tube 49 (61) 39 (61) 0.97 35 (60) 25 (45) 0.11 27 (56) 20 (45) 0.30
Suctioning 34 (43) 25 (39) 0.68 24 (41) 17 (31) 0.25 17 (35) 11 (25) 0.28 Tube in
nose 35 (44) 27 (42) 0.85 26 (45) 23 (42) 0.75 20 (42) 16 (36) 0.60 Ward
rounds 33 (41) 21 (33) 0.30 19 (33) 19 (35) 0.84 18 (38) 17 (39) 0.91 Memories of feelings
Any memory of feelings (≥1 of these
6) 70 (88) 59 (92) 0.36 47 (81) 44 (80) 0.89 40(83) 32 (73) 0.22 Pain 31 (39) 20 (31) 0.35 17 (29) 16 (29) 0.98 10 (21) 10 (23) 0.83 Being
uncomfortab
le 47 (59) 29 (45) 0.11 29 (50) 29 (53)
0.771
9 27 (56) 20 (45) 0.30 Feeling
confused 47 (59) 35 (55) 0.62 28 (48) 25 (45) 0.77 27 (56) 22 (50) 0.55 Feeling
anxious or
frightened 46 (58) 39 (61) 0.68 33 (57) 28 (51) 0.52 23 (48) 23 (52) 0.68 Panic 29 (36) 31 (48) 0.14 17 (29) 19 (35) 0.55 15 (31) 14 (32) 0.95 Feeling
down 30 (38) 18 (28) 0.24 17 (29) 19 (35) 0.55 16 (33) 14 (32) 0.88 Delusional memories
Any delusional memory (≥1
of these 4) 58 (72) 46(72) 0.93 42 (72) 37 (67) 0.55
30
(62) 27(61) 0.91
Hallucinatio
ns 36 (45) 24 (38) 0.36 23 (40) 22 (40) 0.97
19
(39) 15 (34) 0.59 Dreams 43 (54) 37 (58) 0.63 30 (52) 27 (49) 0.78
23
(48) 23 (52) 0.68
Nightmares 26 (33) 20 (31) 0.87 14 (24) 24 (44) 0.03 12
(25) 14 (32) 0.47 Feeling
people were trying to hurt
you 12 (15) 11 (17) 0.72 13 (22) 5 (9) 0.05
14
(29) 7 (16) 0.13
Data presented as N (%) unless otherwise indicated.
Supplemental Table C Recall on days 3, 28 and 90 after discharge
All Patient
Patients who reported they “remembered being
in ICU”
Patients who reported they
“Did not remember being in the ICU
P value*
Day 3 Day 28 Day 90 Day 3 Day 28 Day 90 Day 3 Day 28 Day 90
N 155 121 100 110 88 64 42 31 36
Remember admission to hospital
Clearly 63(41) 56(47) 38(38) 50(46) 46(53) 24(38) 11(26) 10(32) 14(39)
0.07 Hazily 39(26) 18(15) 23(23) 27(25) 13(15) 18(28) 12(29) 4(13) 5(14)
Not at all 51(33) 45(38) 39(39) 31(29) 28(32) 22(34) 19(45) 17(55) 17(47) Remember
time before ICU
All of it 34(22) 13(11) 13(13) 30(28) 11(13) 8(13) 3(7) 2(6) 5(14)
0.51 Some of
it 57(37) 41(35) 36(36) 37(34) 31(36) 27(42) 19(45) 10(32) 9(26) Nothing
at all 63(41) 64(54) 50(51) 42(38) 44(51) 29(45) 20(48) 19(61) 21(60) Remember
being in the ICU
Yes 110(7) 88(74) 64(64)
No 42(28) 31(26) 36(36)
Remember all the stay
Yes 19(12) 10(9) 6(6) 17(15) 10(11) 6(9) 0(0) 0(0) 0(0)
0.06
No 134(88)
108(92
) 94(94) 93(85) 78(89) 58(91) 41(100) 30(100) 36(100) Enough
sleep Yes 76(51) 75(66) 65(71) 50(46) 53(62) 40(66) 24(62) 20(77) 25(81) 0.17
If no, reason
Pain 15(20) 9(24) 6(22) 13(22) 7(22) 6(29) 1(7) 2(33) 0(0) 0.62
Noise 35(47) 19(50) 11(41) 26(45) 16(50) 11(52) 8(53) 3(50) 0(0) 1.0 Bright
light 23(31) 15(40) 9(33) 16(28) 12(38) 8(38) 6(40) 3(50) 1(17) 0.66 Loud
speaking 30(41) 17(45) 9(33) 21(36) 13(41) 9(43) 8(53) 4(67) 0(0) 0.38
Bathing 3(4) 1(3) 4(15) 3(5) 1(3.13) 4(19) 0(0) 0(0) 0(0) 1.0
Tests 22(30) 6(16) 9(33) 16(28) 6(19) 9(43) 5(33) 0(0) 0(0) 0.56
People entering
the room 25(34) 10(26) 10(37) 17(29) 9(28) 10(48) 7(47) 1(17) 0(0) 1.0 Other 30(41) 23(61) 14(52) 27(47) 19(59) 11(52) 3(20) 4(67) 3(30) 1.0 Prefer to
be more
awake Yes 30(21) 26(23) 20(22) 17(16) 18(21) 12(20) 12(31) 7(26) 8(27) 0.59 Remember
transfer from ICU
Clearly 98(65) 65(56) 54(55) 81(75) 55(63) 46(73) 17(44) 9(31) 8(22)
0.0009 Hazily 34(23 ) 39(33) 27(27) 21(19) 27(31) 13(21) 11(28) 12(41) 14(39)
Not at all 18(12) 13(11) 18(18) 6(6) 5(6) 4(6) 11(28) 8(28) 14(39)
* P value – comparison of those with who reported they remembered being in the ICU and those who reported they did not at day 28.
Data presented as N (%) unless otherwise indicated.
Panic or apprehensi
on Yes 39(26) 26(23) 15(16) 29(28) 16(20) 10(17) 9(22) 9(31) 5914) 0.20
Intrusive memories during
ICU Yes 26(18) 21(18) 12(12) 20(20) 14(17) 8(13) 4(10) 5(17) 4(11) 1.0
Talked about it with…
Family
member 107(69) 96(79) 81(81) 75(68) 70(80) 52(81) 29(69) 24(77) 29(81) 0.80 Doctor
on the
ward 13(8) 17(14) 17(17) 9(8) 15(17) 11(18) 3(7) 2(6) 6(17) 0.23
Nurse on
the ward 10(6) 8(7) 7(7) 8(7) 8(9) 6(9) 2(5) 0(0) 1(3) 0.11
family
doctor 1(0.6) 16(13) 17(17) 1(1) 12(14) 12(19) 0(0) 4(13) 5(14) 1.0 No one 34(22) 18(15) 11(11) 24(22) 13915) 4(6) 10(24) 5(16) 5(14) 1.0
Other 8(5) 12(10) 8(8) 5(5) 12(14) 6(9) 3(7) 0(0) 2(6) 0.04