Page 10 of 13 Supplemental Table 2. Significance of each volumetric MRI marker for identifying MCI
subjects that progressed to AD over a 12-month period
Rank ADNI Marker Common Name Site N1 N2 P-value
1 TEMPINFL_uas Left inferior temporal UAS 280 65 4.29E-06
2 TEMPPLSUPL_uas Left superior temporal pole UAS 280 65 1.24E-05
3 HIPPL_uas Left hippocampus UAS 280 65 1.62E-05
4 TEMPINFR_uas Right inferior temporal UAS 280 65 7.39E-05
5 TEMPMIDL_uas Left middle temporal UAS 280 65 8.69E-05
6 LEFTHIPPO_sf2 Left hippocampus SF2 214 45 8.90E-05
7 R_MID_TEMPORAL_ucd Right middle temporal UCD 157 31 9.03E-05
8 L_MID_TEMPORAL_ucd Left middle temporal UCD 157 31 9.73E-05
9 AMYGDR_uas Right amygdala UAS 280 65 0.0001
10 AMYGDL_uas Left amygdala UAS 280 65 0.0002
11 R_INF_TEMPORAL_ucd Right inferior temporal UCD 157 31 0.0002
12 INSULAR_uas Right insula UAS 280 65 0.0003
13 TEMPMIDR_uas Right middle temporal UAS 280 65 0.0003
14 ANGULARL_uas Left angular gyrus UAS 280 65 0.0004
15 RIGHTHIPPO_sf2 Right hippocampus SF2 214 45 0.0004
16 HIPPR_uas Right hippocampus UAS 280 65 0.0005
17 TEMPPLMIDL_uas Left middle temporal pole UAS 280 65 0.0005
18 R_ENTORHINAL_ucd Right entorhinal UCD 157 31 0.0007
19 TEMPPLSUPR_uas Right middle temporal pole UAS 280 65 0.0009
20 L_INF_TEMPORAL_ucd Left inferior temporal UCD 157 31 0.0010
21 TEMPSUPR_uas Right superior temporal UAS 280 65 0.0010
22 PARAHIPPL_uas Left parahippocampul UAS 280 65 0.0014
23 RECTUSR_uas Right rectus UAS 280 65 0.0016
24 L_FUSIFORM_ucd Left fusiform gyrus UCD 157 31 0.0018
25 ROLANDOPR_uas Right rolandic operculum UAS 280 65 0.0018
26 R_AMYGDALA_ucd Right amygdala UCD 157 31 0.0024
27 FUSIFORMR_uas Right fusifrom gyrus UAS 280 65 0.0025
28 FUSIFORML_uas Left fusiform gyrus UAS 280 65 0.0027
29 L_INF_LAT_VENT_ucd Left inferior lateral ventricle UCD 157 31 0.0027
30 INSULAL_uas Left insular UAS 280 65 0.0027
31 SUPRAMARGL_uas Left supramarginal UAS 280 65 0.0029
32 PARAHIPPR_uas Right parahippocampal UAS 280 65 0.0030
33 CAUDATER_uas Right caudate UAS 280 65 0.0032
34 R_FUSIFORM_ucd Right fusifrom gyrus UCD 157 31 0.0034
35 BRAINVOL_bsi Segmented grain volume BSI 281 66 0.0036
36 FRONTSMEDL_uas Left frontal superior medial UAS 280 65 0.0038
37 FRONTINOPL_uas Left inferior frontal operculum UAS 280 65 0.0038
38 R_HIPPOCAMPUS_ucd Right hippocampus UCD 157 31 0.0039
39 TEMPPLMIDR_uas Right middle temporal pole UAS 280 65 0.0039
40 FRONTSMEDR_uas Right frontal superior medial UAS 280 65 0.0041
41 L_HIPPOCAMPUS_ucd Left hippocampus UCD 157 31 0.0047
42 OLFACTL_uas Left olfactory UAS 280 65 0.0054
43 OLFACTR_uas Right olfactory UAS 280 65 0.0054
44 RECTUSL_uas Left rectus UAS 280 65 0.0056
Page 11 of 13
Rank ADNI Marker Common Name Site N1 N2 P-value
45 R_INF_LAT_VENT_ucd Right inferior lateral ventricle UCD 156 31 0.0066
46 FRTMIDORBR_uas Right frontal middle orbital UAS 280 65 0.0066
47 TEMPSUPL_uas Left superior temporal UAS 280 65 0.0074
48 CEREB7BL_uas
Left lobule VIIb of cerebellar
hemisphere UAS 280 65 0.0075
49 FRTMIDORBL_uas Left frontal middle orbital UAS 280 65 0.0077
50 CEREBCR2R_uas
Right crus II of cerebellar
hemisphere UAS 280 65 0.0078
51 FRONTINTRR_uas Right inferior frontal triangular UAS 280 65 0.0080 52 FRONTINOPR_uas Right inferior frontal operculum UAS 280 65 0.0082 53 FRONTINTRL_uas Left frontal inferior triangular UAS 280 65 0.0102 54 FRONTINOBR_uas Right frontal inferior orbital UAS 280 65 0.0109
55 CAUDATEL_uas Left caudate UAS 280 65 0.0111
56 OCCINFL_uas Left inferior occipital UAS 280 65 0.0113
57 CEREB8L_uas
Left lobule VIII of cerebellar
hemisphere UAS 280 65 0.0126
58 HESCHLL_uas Left Heschl's gyrus UAS 280 65 0.0132
59 FRONTINOBL_uas Left frontal inferior orbital UAS 280 65 0.0137
60 VERMIS8_uas Lobule VIII of vermis UAS 280 65 0.0140
61 FRONTSORBR_uas Right frontal superior orbital UAS 280 65 0.0150 62 CEREBCR2L_uas
Left crus II of cerebellar
hemisphere UAS 280 65 0.0156
63 PARIETINFR_uas Right inferior parietal UAS 280 65 0.0158
64 FRONTMIDL_uas Left middle frontal UAS 280 65 0.0167
65 L_AMYGDALA_ucd Left amygdala UCD 157 31 0.0167
66 FRONTMIDR_uas Right middle frontal UAS 280 65 0.0175
67 VERMIS9_uas Lobule IX of vermis UAS 280 65 0.0205
68 L_ENTORHINAL_ucd Left entorhinal UCD 157 31 0.0207
69 SUPMOTORR_uas Right supplementary motor UAS 280 65 0.0214
70 OCCMIDL_uas Left middle occipital UAS 280 65 0.0225
71 AVGJACOB_avg Average Jacobian
Paul
Thompson 226 55 0.0225
72 FRTMEDORBR_uas Right frontal medial orbital UAS 280 65 0.0237
73 PRECUNEUSL_uas Left precuneus UAS 280 65 0.0237
74 SUPMOTORL_uas Left supplementary motor UAS 280 65 0.0242
75 VENTRICLES_ucd Ventricular volume UCD 157 31 0.0248
76 WHOLE_BRAIN_ucd Whole brain volume UCD 157 31 0.0253
77 PARIETINFL_uas Left inferior parietal UAS 280 65 0.0258
78 PRECUNEUSR_uas Right precuneus UAS 280 65 0.0270
79 ROLANDOPL_uas Left Rolandic operculum UAS 280 65 0.0275
80 OCCSUPR_uas Right superior occipital UAS 280 65 0.0283
81 THALAMUSR_uas Right thalamus UAS 280 65 0.0285
82 ANGULARR_uas Right angular UAS 280 65 0.0294
83 CINGANTL_uas Left anterior cingulum UAS 280 65 0.0304
84 OCCINFR_uas Right inferior occipital UAS 280 65 0.0310
85 CEREB9L_uas
Left lobule IX of cerebellar
hemisphere UAS 280 65 0.0312
86 CEREB10L_uas
Left lobule X of cerebellar
hemisphere UAS 280 65 0.0317
87 VERMIS3_uas Lobule III of vermis UAS 280 65 0.0344
88 CINGPOSTL_uas Left posterior cingulum UAS 280 65 0.0348
89 CINGMIDL_uas Left middle cingulum UAS 280 65 0.0364
90 FRONTSORBL_uas Left frontal superior orbital UAS 280 65 0.0379
Page 12 of 13
Rank ADNI Marker Common Name Site N1 N2 P-value
91 FRONTSUPL_uas Left superior frontal UAS 280 65 0.0381
92 CEREB8R_uas
Right lobule VIII of cerebellar
hemisphere UAS 280 65 0.0385
93 PARIETSUPL_uas Left superior parietal UAS 280 65 0.0401
94 CINGMIDR_uas Right middle cingulum UAS 280 65 0.0408
95 LINGUALL_uas Left lingual gyrus UAS 280 65 0.0412
96 CINGANTR_uas Right anterior cingulum UAS 280 65 0.0413
97 SUPRAMARGR_uas Right supramarginal gyrus UAS 280 65 0.0431
98 CEREB9R_uas
Right lobule IX of cerebellar
hemisphere UAS 280 65 0.0436
99 CEREBCR1L_uas
Left crus I of cerebellar
hemisphere UAS 280 65 0.0436
100 CEREB7BR_uas
Right lobule VIIb of cerebellar
hemisphere UAS 280 65 0.0500
101 CALCARINEL_uas Calcarine cortex UAS 280 65 0.0518
102 VENTVOL_bsi Segmented ventricular volume BSI 281 66 0.0518
103 CUNEUSR_uas Right cuneus UAS 280 65 0.0533
104 CEREBCR1R_uas
Right crus I of cerebellar
hemisphere UAS 280 65 0.0580
105 FRTMEDORBL_uas Left frontal medial orbital UAS 280 65 0.0599
106 CEREB6L_uas
Left lobule VI of cerebellar
hemisphere UAS 280 65 0.0637
107 OCCMIDR_uas Right middle occipital UAS 280 65 0.0672
108 CINGPOSTR_uas Right posterior cingulum UAS 280 65 0.0705
109 FRONTSUPR_uas Right superior frontal UAS 280 65 0.0754
110 CALCARINER_uas Right calcarine cortex UAS 280 65 0.0770
111 VERMIS12_uas Lobule XII of vermis UAS 280 65 0.0796
112 VERMIS7_uas Lobule VII of vermis UAS 280 65 0.0798
113 CEREB3R_uas
Right lobule III of cerebellar
hemisphere UAS 280 65 0.0922
114 CEREB45R_uas
Right lobule IV, V of cerebellar
hemisphere UAS 280 65 0.103
115 OCCSUPL_uas Left superior occipital UAS 280 65 0.108
116 VERMIS45_uas Lobule IV, V of vermis UAS 280 65 0.112
117 PRECENTL_uas Left precentral UAS 280 65 0.114
118 VENTVOL_uwo Segmented ventricular volume UWO 262 47 0.115
119 PUTAMENR_uas Right putamen UAS 280 65 0.120
120 HESCHLR_uas Right Heschl's gyrus UAS 280 65 0.126
121 POSTCENTL_uas Left postcentral gyrus UAS 280 65 0.134
122 VERMIS10_uas Lobule X of vermis UAS 280 65 0.135
123 CEREB3L_uas
Left lobule III of cerebellar
hemisphere UAS 280 65 0.137
124 PARIETSUPR_uas Right superior parietal UAS 280 65 0.144
125 CEREB6R_uas
Right lobule VI of cerebellar
hemisphere UAS 280 65 0.156
126 CUNEUSL_uas Left cuneus UAS 280 65 0.184
127 CEREB45L_uas
Left lobule IV, V of cerebellar
hemisphere UAS 280 65 0.185
128 POSTCENTR_uas Right postcentral gyrus UAS 280 65 0.191
129 LINGUALR_uas Right lingual gyrus UAS 280 65 0.194
130 PUTAMENL_uas Left putamen UAS 280 65 0.323
131 PALLIDUMR_uas Right pallidum UAS 280 65 0.367
132 PALLIDUML_uas Left pallidum UAS 280 65 0.416
133 THALAMUSL_uas Left thalamus UAS 280 65 0.471
134 PRECENTR_uas Right precentral UAS 280 65 0.508
Page 13 of 13
Rank ADNI Marker Common Name Site N1 N2 P-value
135 PARCENTLBL_uas Paracentral lobule UAS 280 65 0.535
136 VERMIS6_uas Lobule VI of vermis UAS 280 65 0.567
137 CEREB10R_uas
Right lobule X of cerebellar
hemisphere UAS 280 65 0.737
138 PARCENTLBR_uas Right paracentral lobule UAS 280 65 0.884